Paul J. Mosca, MD, PhD, MBA
Associate Vice Chair of Network General Surgery
Department / Division
Surgery /
Surgical Oncology
Address
3116 North Duke Street
Durham, NC 27704
Appointment Telephone
919-660-2324
Office Telephone
919-660-2324
Fax Telephone
919-660-2362
- MD, University of Virginia School of Medicine, 1995
- General Surgery, Duke University Medical Center, 2002
- PhD, Biophysics, University of Virginia, 1994
- MBA, Healthcare Systems Management, DeSales University (Pennsylvania), 2011
Clinical Interests
General surgery and surgical oncology, with special interest in melanoma and tumors of the liver, pancreas, upper and lower GI tract, skin, soft tissues
Research Interests
My research focuses on two areas. One is the development of more effective and entirely novel treatments for melanoma. I have a special interest in immunotherapy, novel targeted molecular therapies, and regional chemotherapy for advanced melanoma of the arm or leg. Another area of interest is palliative surgery for cancer with an emphasis on understanding the optimal role and application of this type of surgery in the care of advanced malignancy.
This faculty member has no reported relationships with industry.
Representative Publications
Madhunapantula, SV; Mosca, PJ; Robertson, GP. The Akt signaling pathway: an emerging therapeutic target in malignant melanoma. Cancer Biology and Therapy. 2011;12:1032-1049.
(2011)
Abstract
Mosca, PJ; Blazer, DG; Wheeler, JL; Abernethy, AP. When a chance to cut is not a chance to cure: a future for palliative surgery?. Annals of Surgical Oncology. 2011;18:3235-3239.
(2011)
Abstract
Mosca, PJ; Robertson, GP. Augmentation of tumor-specific immunity by upregulation of apoptotic melanoma cell calreticulin expression. Cancer Biology and Therapy. 2011;11:581-583.
(2011)
Abstract
Mosca, PJ; Teicher, E; Nair, SP; Pockaj, BA. Can surgeons improve survival in stage IV melanoma?. Journal of Surgical Oncology. 2008;97:462-468.
(2008)
Abstract
Padussis, JC; Steerman, SN; Tyler, DS; Mosca, PJ. Pharmacokinetics & drug resistance of melphalan in regional chemotherapy: ILP versus ILI. International Journal of Hyperthermia. 2008;24:239-249.
(2008)
Abstract
Agostino, NM; Ali, A; Nair, SG; Mosca, PJ. Current immunotherapeutic strategies in malignant melanoma. Surgical Oncology Clinics of North America. 2007;16:945-xi.
(2007)
Abstract
Mosca, PJ; Lyerly, HK; Clay, TM; Morse, MA; Lyerly, HK. Dendritic cell vaccines. Frontiers in Bioscience. 2007;12:4050-4060.
(2007)
Abstract
Hall, JG; Herman, C; Cook, JL; Tyler, D; Seigler, HF; Mosca, PJ. Melanoma arising in a skin graft. Annals of Plastic Surgery. 2005;54:92-96.
(2005)
Abstract
Mosca, PJ; Tyler, DS; Seigler, HF. Surgical management of cutaneous melanoma: current practice and impact on prognosis. Advances in Surgery. 2004;38:85-119.
(2004)
Abstract
Mosca, PJ; Clay, TM; Kim Lyerly, H; Morse, MA. Current status of dendritic cell immunotherapy of malignancies. International Reviews of Immunology. 2003;22:255-281.
(2003)
Abstract
Mosca, PJ; Lyerly, HK; Ching, CD; Hobeika, AC; Clay, TM; Morse, MA. Proteomics for monitoring immune responses to cancer vaccines. Current Opinion in Molecular Therapeutics. 2003;5:39-43.
(2003)
Abstract
Mosca, PJ; Hobeika, AC; Colling, K; Clay, TM; Thomas, EK; Caron, D; Lyerly, HK; Morse, MA. Multiple signals are required for maturation of human dendritic cells mobilized in vivo with Flt3 ligand. Journal of Leukocyte Biology. 2002;72:546-553.
(2002)
Abstract
Mosca, PJ; Hobeika, AC; Clay, TM; Morse, MA; Lyerly, HK. Direct detection of cellular immune responses to cancer vaccines. Surgery. 2001;129:248-254.
(2001)
Abstract
Mosca, PJ; Hobeika, AC; Clay, TM; Nair, SK; Thomas, EK; Morse, MA; Lyerly, HK. A subset of human monocyte-derived dendritic cells expresses high levels of interleukin-12 in response to combined CD40 ligand and interferon-gamma treatment. Blood. 2000;96:3499-3504.
(2000)
Abstract
Mosca, PJ; Morse, MA; D'Amico, TA; Crawford, J; Lyerly, HK. Gene therapy for lung cancer. Clinical Lung Cancer. 2000;1:218-226.
(2000)
Abstract
