Physicians

Department / Division
Ophthalmology / Retinal Ophthalmology

Address
DUMC 3802
Durham, NC 27710

Appointment Telephone
919-681-3937

Office Telephone
919-684-5631

Fax Telephone
919-681-6474

Training

• MD, University of Pennsylvania School of Medicine

Residency

• Ophthalmology, Scheie Eye Institute, University of Pennsylvania

Fellowship

• Vitreoretinal Surgery and Diseases, Duke Eye Center

Other Training

• PhD, Molecular Pharmacology, University of Pennsylvania

Clinical Interests
Vitreous and retinal diseases, macular surgery, retinal detachment repair, advanced diabetic retinopathy, medical diagnosis and treatment of age-related macular degeneration, retinal vascular disease

Research Interests
I have been extensively involved in research throughout my academic career. While an undergraduate at Harvard College, I studied various proteins at an ultrastructural level towards rational design of novel drugs. During medical school at the University of Pennsylvania, I continued with basic science research studying mechanisms of action of nuclear receptors and optimizing protocols for gene therapy. I completed my PhD at the University of Pennsylvania studying the role of iron overload as a potential toxic cofactor in the pathogenesis of age-related macular degeneration.

My current research at Duke University focuses on developing novel methods to improve patient care in a surgical, clinical, and scientific setting. We are actively developing a microscope-integrated OCT device to enable simultaneous, real-time OCT acquisition during surgical maneuvers. This novel imaging modality would certainly provide unprecedented three-dimensional information during surgery, which will likely result in previously unidentified prognostic information for post-surgical outcomes. In the clinic setting, we are also developing a novel microfluidics platform towards point-of-care analysis of intraocular fluids. Such a platform will likely prove important for personalized treatment, particularly of multifactorial diseases such as AMD. These research avenues complement basic science research examining novel mechanisms of cell death in order to understand why cells die in retinal degenerations, particularly age-related macular degeneration.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Hahn, P; Migacz, J; O'Connell, R; Izatt, JA; Toth, CA. Unprocessed real-time imaging of vitreoretinal surgical maneuvers using a microscope-integrated spectral-domain optical coherence tomography system. Graefes Archive for Clinical and Experimental Ophthalmology. 2013;251:213-220. (2013) Abstract

Hahn, P; Fekrat, S. Best practices for treatment of retinal vein occlusion. Current Opinion in Ophthalmology. 2012;23:175-181. (2012) Abstract

Lin, P; Hahn, P; Fekrat, S. Peripheral retinal vascular leakage demonstrated by ultra-widefield fluorescein angiography in preeclampsia with HELLP syndrome. Retina: the Journal of Retinal and Vitreous Diseases. 2012;32:1689-1690. (2012) Abstract

Hahn, P; Migacz, J; O'Connell, R; Maldonado, RS; Izatt, JA; Toth, CA. The use of optical coherence tomography in intraoperative ophthalmic imaging. Ophthalmic Surgery, Lasers and Imaging. 2011;42 Suppl:S85-S94. (2011) Abstract

Hahn, P; Song, Y; Ying, GS; He, X; Beard, J; Dunaief, JL. Age-dependent and gender-specific changes in mouse tissue iron by strain. Experimental Gerontology. 2009;44:594-600. (2009) Abstract

Bhisitkul, RB; Winn, BJ; Lee, OT; Wong, J; Pereira, DDES; Porco, TC; He, X; Hahn, P; Dunaief, JL. Neuroprotective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in a rabbit model of subretinal hemorrhage. Investigative Ophthalmology and Visual Science. 2008;49:4071-4077. (2008) Abstract

Hadziahmetovic, M; Dentchev, T; Song, Y; Haddad, N; He, X; Hahn, P; Pratico, D; Wen, R; Harris, ZL; Lambris, JD; Beard, J; Dunaief, JL. Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. Investigative Ophthalmology and Visual Science. 2008;49:2728-2736. (2008) Abstract

He, X; Hahn, P; Iacovelli, J; Wong, R; King, C; Bhisitkul, R; Massaro-Giordano, M; Dunaief, JL. Iron homeostasis and toxicity in retinal degeneration. Progress in Retinal and Eye Research. 2007;26:649-673. (2007) Abstract

Wong, RW; Richa, DC; Hahn, P; Green, WR; Dunaief, JL. Iron toxicity as a potential factor in AMD. Retina: the Journal of Retinal and Vitreous Diseases. 2007;27:997-1003. (2007) Abstract

Hahn, P; Ying, GS; Beard, J; Dunaief, JL. Iron levels in human retina: sex difference and increase with age. Neuroreport. 2006;17:1803-1806. (2006) Abstract

Dentchev, T; Hahn, P; Dunaief, JL. Strong labeling for iron and the iron-handling proteins ferritin and ferroportin in the photoreceptor layer in age-related macular degeneration. Archives of Ophthalmology. 2005;123:1745-1746. (2005) Abstract

Hahn, P; Lindsten, T; Tolentino, M; Thompson, CB; Bennett, J; Dunaief, JL. Persistent fetal ocular vasculature in mice deficient in bax and bak. Archives of Ophthalmology. 2005;123:797-802. (2005) Abstract

Hahn, P; Dentchev, T; Qian, Y; Rouault, T; Harris, ZL; Dunaief, JL. Immunolocalization and regulation of iron handling proteins ferritin and ferroportin in the retina. Molecular Vision. 2004;10:598-607. (2004) Abstract

Hahn, P; Lindsten, T; Lyubarsky, A; Ying, GS; Pugh, EN; Thompson, CB; Dunaief, JL. Deficiency of Bax and Bak protects photoreceptors from light damage in vivo. Cell Death and Differentiation. 2004;11:1192-1197. (2004) Abstract

Hahn, P; Qian, Y; Dentchev, T; Chen, L; Beard, J; Harris, ZL; Dunaief, JL. Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proceedings of the National Academy of Sciences of USA. 2004;101:13850-13855. (2004) Abstract

Hahn, P; Lindsten, T; Ying, GS; Bennett, J; Milam, AH; Thompson, CB; Dunaief, JL. Proapoptotic bcl-2 family members, Bax and Bak, are essential for developmental photoreceptor apoptosis. Investigative Ophthalmology and Visual Science. 2003;44:3598-3605. (2003) Abstract

Hahn, P; Milam, AH; Dunaief, JL. Maculas affected by age-related macular degeneration contain increased chelatable iron in the retinal pigment epithelium and Bruch's membrane. Archives of Ophthalmology. 2003;121:1099-1105. (2003) Abstract