Patricia L. Lugar, MD, MS
Department / Division
Medicine /
Medicine-Pulmonary
Address
4309 Medical Park Drive, Suite 100
Durham, NC 27704
Appointment Telephone
919-668-7630
Office Telephone
919-620-7306
Fax Telephone
919-471-5374
- MD, University at Buffalo SUNY School of Medicine & Biomedical Sciences, 1999
- Internal Medicine, McGaw Medical Center-Northwestern University (Illinois), 2001
- Allergy and Immunology, National Institutes of Health (Maryland), 2007
- MS, Molecular Medicine and Immunology, Roswell Park Cancer Institute (New York), 1998
Clinical Interests
All conditions related to allergy and immunology, with particular interest in chronic urticaria, common variable immunodeficiency (CVID), and the immunologic mechanism of immunoglobulin therapy (IVIG) and allergen immunotherapy, angioedema, mast-cell disorders
Research Interests
I have a strong interest and research background in the study of dysregulated B lymphocytes, B cells, that characterize clinical disease such as autoimmune disease and humoral immune deficiency. My current research projects are aimed at the study of humoral immune deficiency, specifically common variable immune deficiency or CVID and the dysregulation of B cells in the generation of lymphoma and autoimmune disease.
Other ongoing research projects include characterizing the molecular and cellular events that cause a common disease, chronic idiopathic urticaria or CIU and rare disorders idiopathic anaphylaxis and idiopathic angioedema.
This physician has no reported relationships with industry.
Representative Publications
Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs.
Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Yan Au W, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI, Liu Q, How T, Grubor V, Gao Y, Patel A, Wu H, Zhu J, Blobe GC, Lipsky PE, Chadburn A, Dave SS; Hematologic Malignancies Research Consortium. Blood. 2010 Dec 2;116(23):e118-27. Epub 2010 Aug 23.PMID: 20733160
Patterns of microRNA expression characterize stages of human B-cell differentiation. Zhang J, Jima DD, Jacobs C, Fischer R, Gottwein E, Huang G, Lugar PL, Lagoo AS, Rizzieri DA, Friedman DR, Weinberg JB, Lipsky PE, Dave SS. Blood. 2009 May 7;113(19):4586-94. Epub 2009 Feb 6.PMID: 19202128
Analysis of somatic hypermutation in X-linked hyper-IgM syndrome shows specific deficiencies in mutational targeting.
Longo NS, Lugar PL, Yavuz S, Zhang W, Krijger PH, Russ DE, Jima DD, Dave SS, Grammer AC, Lipsky PE. Blood. 2009 Apr 16;113(16):3706-15. PMID: 19023113
Regulation of the germinal center gene program by interferon (IFN) regulatory factor 8/IFN consensus sequence-binding protein.
Lee CH, Melchers M, Wang H, Torrey TA, Slota R, Qi CF, Kim JY, Lugar P, Kong HJ, Farrington L, van der Zouwen B, Zhou JX, Lougaris V, Lipsky PE, Grammer AC, Morse HC 3rd. J Exp Med. 2006 Jan 23;203(1):63-72. Epub 2005 Dec 27. Erratum in: J Exp Med. 2008 Jun 9;205(6):1507. J Exp Med. 2006 Feb 20;203(2):475. PMID: 16380510
