Nelson J. Chao, MD, MBA
Chief, Division of Cellular Therapy
Departments / Divisions- Medicine / Medicine - Cell Therapy and Hematologica
- Immunology
- Pathology
Address
DUMC 3961
Durham, NC 27710
Appointment Telephone
919-668-1000
Office Telephone
919-668-1010
Fax Telephone
919-668-1091
- MD, Yale University School of Medicine (Connecticut), 1981
- Medicine, Stanford University Medical Center (California), 1981-1984
- Oncology, Stanford University Medical Center (California), 1985-1987
- MBA, Duke University Fuqua School of Business, 2000
Clinical Interests
Hematology, oncology, bone-marrow transplantation
Research Interests
My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.
For more information see http://ed-media.mc.duke.edu/BMT.nsf
This faculty member has no reported relationships with industry.
Representative Publications
Chao, NJ; Liu, CX; Rooney, B; Chen, BJ; Long, GD; Vredenburgh, JJ; Morris, A; Gasparetto, C; Rizzieri, DA. Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells. Biology of Blood and Marrow Transplantation. 2002;8:249-256.
(2002)
Abstract
Chen, BJ; Chen, Y; Cui, X; Fidler, JM; Chao, NJ. Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation model. Transplantation. 2002;73:115-121.
(2002)
Abstract
Chen, BJ; Cui, X; Chao, NJ. Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation. Blood. 2002;99:2235-2240.
(2002)
Abstract
Chen, BJ; Cui, X; Liu, C; Chao, NJ. Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging process. Blood. 2002;99:3083-3088.
(2002)
Abstract
Chen, BJ; Cui, X; Sempowski, GD; Gooding, ME; Liu, C; Haynes, BF; Chao, NJ. A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. Blood. 2002;99:364-371.
(2002)
Abstract
Gasparetto, C; Gasparetto, M; Morse, M; Rooney, B; Vredenburgh, JJ; Long, GD; Rizzieri, DA; Loftis, J; Chao, NJ; Smith, C. Mobilization of dendritic cells from patients with breast cancer into peripheral blood stem cell leukapheresis samples using Flt-3-Ligand and G-CSF or GM-CSF. Cytokine. 2002;18:8-19.
(2002)
Abstract
McCune, SL; Gockerman, JP; Moore, JO; Decastro, CM; Bass, AJ; Chao, NJ; Long, GD; Vredenburgh, JJ; Gasparetto, C; Adams, D; Payne, N; Rizzieri, DA. Alemtuzumab in relapsed or refractory chronic lymphocytic leukemia and prolymphocytic leukemia. Leukemia and Lymphoma. 2002;43:1007-1011.
(2002)
Abstract
Morse, MA; Rizzieri, D; Stenzel, TT; Hobeika, AC; Vredenburgh, JJ; Chao, NJ; Clay, TM; Mosca, PJ; Lyerly, HK. Dendritic cell recovery following nonmyeloablative allogeneic stem cell transplants. Stem Cells and Development. 2002;11:659-668.
(2002)
Abstract
Boeckh, M; Bowden, RA; Storer, B; Chao, NJ; Spielberger, R; Tierney, DK; Gallez-Hawkins, G; Cunningham, T; Blume, KG; Levitt, D; Zaia, JA. Randomized, placebo-controlled, double-blind study of a cytomegalovirus-specific monoclonal antibody (MSL-109) for prevention of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation. 2001;7:343-351.
(2001)
Abstract
Goker, H; Haznedaroglu, IC; Chao, NJ. Acute graft-vs-host disease: pathobiology and management. Experimental Hematology. 2001;29:259-277.
(2001)
Abstract
Horning, SJ; Negrin, RS; Hoppe, RT; Rosenberg, SA; Chao, NJ; Long, GD; Brown, BW; Blume, KG. High-dose therapy and autologous bone marrow transplantation for follicular lymphoma in first complete or partial remission: results of a phase II clinical trial. Blood. 2001;97:404-409.
(2001)
Abstract
Klein, AK; Patel, DD; Gooding, ME; Sempowski, GD; Chen, BJ; Liu, C; Kurtzberg, J; Haynes, BF; Chao, NJ. T-Cell recovery in adults and children following umbilical cord blood transplantation. Biology of Blood and Marrow Transplantation. 2001;7:454-466.
(2001)
Abstract
Rizzieri, DA; Long, GD; Vredenburgh, JJ; Gasparetto, C; Morris, A; Stenzel, TT; Davis, P; Chao, NJ. Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen. Blood. 2001;98:3486-3488.
(2001)
Abstract
Alvarnas, JC; Negrin, RS; Horning, SJ; Hu, WW; Long, GD; Schriber, JR; Stockerl-Goldstein, K; Tierney, K; Wong, R; Blume, KG; Chao, NJ. High-dose therapy with hematopoietic cell transplantation for patients with central nervous system involvement by non-Hodgkin's lymphoma. Biology of Blood and Marrow Transplantation. 2000;6:352-358.
(2000)
Abstract
Bhalla, KS; Wilczynski, SW; Abushamaa, AM; Petros, WP; McDonald, CS; Loftis, JS; Chao, NJ; Vredenburgh, JJ; Folz, RJ. Pulmonary toxicity of induction chemotherapy prior to standard or high-dose chemotherapy with autologous hematopoietic support. American Journal of Respiratory and Critical Care Medicine. 2000;161:17-25.
(2000)
Abstract
Brodwater, BK; Silber, JS; Smith, TP; Chao, NJ; Suhocki, PV; Ryan, JM; Newman, GE. Conversion of indwelling chest port catheters to tunneled central venous catheters. Journal of Vascular and Interventional Radiology. 2000;11:1137-1142.
(2000)
Abstract
Chao, NJ. Progress in graft-versus-host disease. Stem Cells and Development. 2000;9:295-296.
(2000)
Abstract
Chao, NJ; Snyder, DS; Jain, M; Wong, RM; Niland, JC; Negrin, RS; Long, GD; Hu, WW; Stockerl-Goldstein, KE; Johnston, LJ; Amylon, MD; Tierney, DK; O'Donnell, MR; Nademanee, AP; Parker, P; Stein, A; Molina, A; Fung, H; Kashyap, A; Kohler, S; Spielberger, R; Krishnan, A; Rodriguez, R; Forman, SJ; Bluzme, KG. Equivalence of 2 effective graft-versus-host disease prophylaxis regimens: results of a prospective double-blind randomized trial. Biology of Blood and Marrow Transplantation. 2000;6:254-261.
(2000)
Abstract
Chen, BJ; Liu, C; Cui, X; Fidler, JM; Chao, NJ. Prevention of graft-versus-host disease by a novel immunosuppressant, PG490-88, through inhibition of alloreactive T cell expansion. Transplantation. 2000;70:1442-1447.
(2000)
Abstract
Chen, BJ; Morris, RE; Chao, NJ. Graft-versus-host disease prevention by rapamycin: cellular mechanisms. Biology of Blood and Marrow Transplantation. 2000;6:529-536.
(2000)
Abstract
Chen, Y; Zeng, D; Schlegel, PG; Fidler, J; Chao, NJ. PG27, an extract of Tripterygium wilfordii hook f, induces antigen-specific tolerance in bone marrow transplantation in mice. Blood. 2000;95:705-710.
(2000)
Abstract
Hu, WW; Negrin, RS; Stockerl-Goldstein, K; Johnston, LJ; Shizuru, JA; Wong, RM; Chao, NJ; Long, GD; Feiner, RH; Blume, KG. Four-cycle high-dose therapy with hematopoietic support for metastatic breast cancer: no improvement in outcomes compared with single-course high-dose therapy. Biology of Blood and Marrow Transplantation. 2000;6:58-69.
(2000)
Abstract
Shbarou, RM; Chao, NJ; Morgenlander, JC. Cyclosporin A-related cerebral vasculopathy. Bone Marrow Transplantation. 2000;26:801-804.
(2000)
Abstract
Ferrara, JL; Levy, R; Chao, NJ. Pathophysiologic mechanisms of acute graft-vs.-host disease. Biology of Blood and Marrow Transplantation. 1999;5:347-356.
(1999)
Abstract
Hu, WW; Long, GD; Stockerl-Goldstein, KE; Johnston, LJ; Chao, NJ; Negrin, RS; Blume, KG. A feasibility study of multiple cycle therapy with melphalan, thiotepa, and paclitaxel followed by mitoxantrone, thiotepa, and paclitaxel with autologous hematopoietic cell support for metastatic breast cancer. Clinical Cancer Research. 1999;5:3411-3418.
(1999)
Abstract
Nieto, Y; Cagnoni, PJ; Shpall, EJ; Xu, X; Murphy, J; Vredenburgh, J; Chao, NJ; Bearman, SI; Jones, RB. A predictive model for relapse in high-risk primary breast cancer patients treated with high-dose chemotherapy and autologous stem-cell transplant. Clinical Cancer Research. 1999;5:3425-3431.
(1999)
Abstract
Rizzieri, DA; Vredenburgh, JJ; Jones, R; Ross, M; Shpall, EJ; Hussein, A; Broadwater, G; Berry, D; Petros, WP; Gilbert, C; Affronti, ML; Coniglio, D; Rubin, P; Elkordy, M; Long, GD; Chao, NJ; Peters, WP. Prognostic and predictive factors for patients with metastatic breast cancer undergoing aggressive induction therapy followed by high-dose chemotherapy with autologous stem-cell support. Journal of Clinical Oncology. 1999;17:3064-3074.
(1999)
Abstract
Ross, M; Schmidt, GM; Niland, JC; Amylon, MD; Dagis, AC; Long, GD; Nademanee, AP; Negrin, RS; O'Donnell, MR; Parker, PM; Smith, EP; Snyder, DS; Stein, AS; Wong, RM; Forman, SJ; Blume, KG; Chao, NJ. Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prevention of acute graft-vs.-host disease: effect on chronic graft-vs.-host disease and long-term survival. Biology of Blood and Marrow Transplantation. 1999;5:285-291.
(1999)
Abstract
Laughlin, MJ; McGaughey, DS; Crews, JR; Chao, NJ; Rizzieri, D; Ross, M; Gockerman, J; Cirrincione, C; Berry, D; Mills, L; Defusco, P; LeGrand, S; Peters, WP; Vredenburgh, JJ. Secondary myelodysplasia and acute leukemia in breast cancer patients after autologous bone marrow transplant. Journal of Clinical Oncology. 1998;16:1008-1012.
(1998)
Abstract
Aharoni, R; Schlegel, PG; Teitelbaum, D; Roikhel-Karpov, O; Chen, Y; Arnon, R; Sela, M; Chao, NJ. Studies on the mechanism and specificity of the effect of the synthetic random copolymer GLAT on graft-versus-host disease. Immunology Letters. 1997;58:79-87.
(1997)
Abstract
Chao, NJ. Graft-versus-host disease: the viewpoint from the donor T cell. Biology of Blood and Marrow Transplantation. 1997;3:1-10.
(1997)
Abstract
Chen, Y; Schlegel, PG; Tran, N; Thompson, D; Zehnder, JL; Chao, NJ. Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease. Blood. 1997;89:1452-1459.
(1997)
Abstract
Horning, SJ; Chao, NJ; Negrin, RS; Hoppe, RT; Long, GD; Hu, WW; Wong, RM; Brown, BW; Blume, KG. High-dose therapy and autologous hematopoietic progenitor cell transplantation for recurrent or refractory Hodgkin's disease: analysis of the Stanford University results and prognostic indices. Blood. 1997;89:801-813.
(1997)
Abstract
Kohler, S; Hendrickson, MR; Chao, NJ; Smoller, BR. Value of skin biopsies in assessing prognosis and progression of acute graft-versus-host disease. American Journal of Surgical Pathology. 1997;21:988-996.
(1997)
Abstract
Kusnierz-Glaz, CR; Schlegel, PG; Wong, RM; Schriber, JR; Chao, NJ; Amylon, MD; Hu, WW; Negrin, RS; Lee, Y; Blume, KG; Long, GD. Influence of age on the outcome of 500 autologous bone marrow transplant procedures for hematologic malignancies. Journal of Clinical Oncology. 1997;15:18-25.
(1997)
Abstract
Lee, PP; Zeng, D; McCaulay, AE; Chen, YF; Geiler, C; Umetsu, DT; Chao, NJ. T helper 2-dominant antilymphoma immune response is associated with fatal outcome. Blood. 1997;90:1611-1617.
(1997)
Abstract
Long, GD; Amylon, MD; Stockerl-Goldstein, KE; Negrin, RS; Chao, NJ; Hu, WW; Nademanee, AP; Snyder, DS; Hoppe, RT; Vora, N; Wong, R; Niland, J; Reichardt, VL; Forman, SJ; Blume, KG. Fractionated total-body irradiation, etoposide, and cyclophosphamide followed by allogeneic bone marrow transplantation for patients with high-risk or advanced-stage hematological malignancies. Biology of Blood and Marrow Transplantation. 1997;3:324-330.
(1997)
Abstract
Rizzieri, DA; Chao, NJ. Treatment of non-Hodgkin's lymphoma with high-dose therapy and hematopoietic stem cell support. Current Opinion in Oncology. 1997;9:420-427.
(1997)
Abstract
Behar, E; Chao, NJ; Hiraki, DD; Krishnaswamy, S; Brown, BW; Zehnder, JL; Grumet, FC. Polymorphism of adhesion molecule CD31 and its role in acute graft-versus-host disease. New England Journal of Medicine. 1996;334:286-291.
(1996)
Abstract
Chao, NJ; Parker, PM; Niland, JC; Wong, RM; Dagis, A; Long, GD; Nademanee, AP; Negrin, RS; Snyder, DS; Hu, WW; Gould, KA; Tierney, DK; Zwingenberger, K; Forman, SJ; Blume, KG. Paradoxical effect of thalidomide prophylaxis on chronic graft-vs.-host disease. Biology of Blood and Marrow Transplantation. 1996;2:86-92.
(1996)
Abstract
Kastrissios, H; Chao, NJ; Blaschke, TF. Pharmacokinetics of high-dose oral CCNU in bone marrow transplant patients. Cancer Chemotherapy and Pharmacology. 1996;38:425-430.
(1996)
Abstract
Long, GD; Chao, NJ; Hu, WW; Negrin, RS; Wong, RM; Blume, KG. High dose etoposide-based myeloablative therapy followed by autologous blood progenitor cell rescue in the treatment of multiple myeloma. Cancer. 1996;78:2502-2509.
(1996)
Abstract
Parker, P; Chao, NJ; Ben-Ezra, J; Slatkin, N; Openshaw, H; Niland, JC; Linker, CA; Greffe, BS; Kashyap, A; Molina, A; Nademanee, A; O'Donnell, MR; Planas, I; Sheibani, K; Smith, EP; Snyder, DS; Spielberger, R; Stein, AS; Stepan, DE; Blume, KG; Forman, SJ. Polymyositis as a manifestation of chronic graft-versus-host disease. Medicine. 1996;75:279-285.
(1996)
Abstract
Schlegel, PG; Aharoni, R; Chen, Y; Chen, J; Teitelbaum, D; Arnon, R; Sela, M; Chao, NJ. A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo. Proceedings of the National Academy of Sciences of USA. 1996;93:5061-5066.
(1996)
Abstract
Schlegel, PG; Chao, NJ. Immunomodulatory peptides with high binding affinity for class II MHC molecules for the prevention of graft-versus-host disease. Leukemia and Lymphoma. 1996;23:11-16.
(1996)
Abstract
Stockerl-Goldstein, KE; Horning, SJ; Negrin, RS; Chao, NJ; Hu, WW; Long, GD; Hoppe, RT; Amylon, MD; Brown, BW; Wong, RM; Blume, KG. Influence of preparatory regimen and source of hematopoietic cells on outcome of autotransplantation for non-Hodgkin's lymphoma. Biology of Blood and Marrow Transplantation. 1996;2:76-85.
(1996)
Abstract
Chao, NJ. Mobilization of peripheral blood progenitor cells by hematopoietic growth factors. The Canadian journal of oncology. 1995;5 Suppl 1:43-46.
(1995)
Abstract
Chao, NJ; Blume, KG; Forman, SJ; Snyder, DS. Long-term follow-up of allogeneic bone marrow recipients for Philadelphia chromosome-positive acute lymphoblastic leukemia. Blood. 1995;85:3353-3354.
(1995)
Abstract
Chao, NJ; Kastrissios, H; Long, GD; Negrin, RS; Horning, SJ; Wong, RM; Blaschke, TF; Blume, KG. A new preparatory regimen for autologous bone marrow transplantation for patients with lymphoma. Cancer. 1995;75:1354-1359.
(1995)
Abstract
Chao, NJ; Schlegel, PG. Prevention and treatment of graft-versus-host disease. Annals of the New York Academy of Sciences. 1995;770:130-140.
(1995)
Abstract
Fernandez, LP; Schlegel, PG; Baker, J; Chen, Y; Chao, NJ. Does thalidomide affect IL-2 response and production?. Experimental Hematology. 1995;23:978-985.
(1995)
Abstract
Long, GD; Negrin, RS; Hoyle, CF; Kusnierz-Glaz, CR; Schriber, JR; Blume, KG; Chao, NJ. Multiple cycles of high dose chemotherapy supported by hematopoietic progenitor cells as treatment for patients with advanced malignancies. Cancer. 1995;76:860-868.
(1995)
Abstract
Negrin, RS; Kusnierz-Glaz, CR; Still, BJ; Schriber, JR; Chao, NJ; Long, GD; Hoyle, C; Hu, WW; Horning, SJ; Brown, BW. Transplantation of enriched and purged peripheral blood progenitor cells from a single apheresis product in patients with non-Hodgkin's lymphoma. Blood. 1995;85:3334-3341.
(1995)
Abstract
Schlegel, PG; Vaysburd, M; Chen, Y; Butcher, EC; Chao, NJ. Inhibition of T cell costimulation by VCAM-1 prevents murine graft-versus-host disease across minor histocompatibility barriers. Journal of Immunology. 1995;155:3856-3865.
(1995)
Abstract
Zaia, JA; Schmidt, GM; Chao, NJ; Rizk, NW; Nademanee, AP; Niland, JC; Horak, DA; Lee, J; Gallez-Hawkins, G; Kusnierz-Glaz, CR. Preemptive ganciclovir administration based solely on asymptomatic pulmonary cytomegalovirus infection in allogeneic bone marrow transplant recipients: long-term follow-up. Biology of Blood and Marrow Transplantation. 1995;1:88-93.
(1995)
Abstract
Blume, KG; Long, GD; Negrin, RS; Chao, NJ; Kusnierz-Glaz, C; Amylon, MD. Role of etoposide (VP-16) in preparatory regimens for patients with leukemia or lymphoma undergoing allogeneic bone marrow transplantation. Bone Marrow Transplantation. 1994;14 Suppl 4:S9-10.
(1994)
Abstract
Chao, NJ; Schriber, JR; Long, GD; Negrin, RS; Catolico, M; Brown, BW; Miller, LL; Blume, KG. A randomized study of erythropoietin and granulocyte colony-stimulating factor (G-CSF) versus placebo and G-CSF for patients with Hodgkin's and non-Hodgkin's lymphoma undergoing autologous bone marrow transplantation. Blood. 1994;83:2823-2828.
(1994)
Abstract
Schlegel, PG; Aharoni, R; Smilek, DE; Fernandez, LP; McDevitt, HO; Tran, N; Vaysburd, M; Chao, NJ. Prevention of graft-versus-host disease by peptides binding to class II major histocompatibility complex molecules. Blood. 1994;84:2802-2810.
(1994)
Abstract
Schriber, JR; Chao, NJ; Long, GD; Negrin, RS; Tierney, DK; Kusnierz-Glaz, C; Lucas, KS; Blume, KG. Granulocyte colony-stimulating factor after allogeneic bone marrow transplantation. Blood. 1994;84:1680-1684.
(1994)
Abstract
Snyder, DS; Negrin, RS; O'Donnell, MR; Chao, NJ; Amylon, MD; Long, GD; Nademanee, AP; Stein, AS; Parker, PM; Smith, EP. Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase. Blood. 1994;84:1672-1679.
(1994)
Abstract
Chao, NJ; Berry, GJ; Advani, R; Horning, SJ; Weiss, LM; Blume, KG. Epstein-Barr virus-associated lymphoproliferative disorder following autologous bone marrow transplantation for non-Hodgkin's lymphoma. Transplantation. 1993;55:1425-1428.
(1993)
Abstract
Chao, NJ; Schmidt, GM; Niland, JC; Amylon, MD; Dagis, AC; Long, GD; Nademanee, AP; Negrin, RS; O'Donnell, MR; Parker, PM. Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-versus-host disease. New England Journal of Medicine. 1993;329:1225-1230.
(1993)
Abstract
Chao, NJ; Schriber, JR; Grimes, K; Long, GD; Negrin, RS; Raimondi, CM; Horning, SJ; Brown, SL; Miller, L; Blume, KG. Granulocyte colony-stimulating factor "mobilized" peripheral blood progenitor cells accelerate granulocyte and platelet recovery after high-dose chemotherapy. Blood. 1993;81:2031-2035.
(1993)
Abstract
Chao, NJ; Stein, AS; Long, GD; Negrin, RS; Amylon, MD; Wong, RM; Forman, SJ; Blume, KG. Busulfan/etoposide--initial experience with a new preparatory regimen for autologous bone marrow transplantation in patients with acute nonlymphoblastic leukemia. Blood. 1993;81:319-323.
(1993)
Abstract
Kühl, JS; Durán, GE; Chao, NJ; Sikic, BI. Effects of the methoxymorpholino derivative of doxorubicin and its bioactivated form versus doxorubicin on human leukemia and lymphoma cell lines and normal bone marrow. Cancer Chemotherapy and Pharmacology. 1993;33:10-16.
(1993)
Abstract
Schmidt, GM; Niland, JC; Forman, SJ; Fonbuena, PP; Dagis, AC; Grant, MM; Ferrell, BR; Barr, TA; Stallbaum, BA; Chao, NJ. Extended follow-up in 212 long-term allogeneic bone marrow transplant survivors. Issues of quality of life. Transplantation. 1993;55:551-557.
(1993)
Abstract
Schriber, JR; Negrin, RS; Chao, NJ; Long, GD; Horning, SJ; Blume, KG. The efficacy of granulocyte colony-stimulating factor following autologous bone marrow transplantation for non-Hodgkin's lymphoma with monoclonal antibody purged bone marrow. Leukemia. 1993;7:1491-1495.
(1993)
Abstract
Snyder, DS; Chao, NJ; Amylon, MD; Taguchi, J; Long, GD; Negrin, RS; Nademanee, AP; O'Donnell, MR; Schmidt, GM; Stein, AS. Fractionated total body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 99 patients with acute leukemia in first complete remission. Blood. 1993;82:2920-2928.
(1993)
Abstract
Advani, R; Chao, NJ; Horning, SJ; Blume, KG; Ahn, DK; Lamborn, KR; Fleming, NC; Bonnem, EM; Greenberg, PL. Granulocyte-macrophage colony-stimulating factor (GM-CSF) as an adjunct to autologous hemopoietic stem cell transplantation for lymphoma. Annals of Internal Medicine. 1992;116:183-189.
(1992)
Abstract
Chao, NJ. Graft versus host disease following allogeneic bone marrow transplantation. Current Opinion in Immunology. 1992;4:571-576.
(1992)
Abstract
Chao, NJ; Aihara, M; Kühl, JS; Sikic, BI; Blume, KG. Purging multidrug resistant cells from bone marrow. Progress in Clinical and Biological Research. 1992;377:13-23.
(1992)
Abstract
Chao, NJ; Long, GD; Negrin, RS; Schriber, JR; Raimondi, CM; Brown, SL; Blume, KG. G-CSF and peripheral blood progenitor cells. Lancet. 1992;339:1410.
(1992)
Abstract
Chao, NJ; Tierney, DK; Bloom, JR; Long, GD; Barr, TA; Stallbaum, BA; Wong, RM; Negrin, RS; Horning, SJ; Blume, KG. Dynamic assessment of quality of life after autologous bone marrow transplantation. Blood. 1992;80:825-830.
(1992)
Abstract
Kühl, JS; Sikic, BI; Blume, KG; Chao, NJ. Use of etoposide in combination with cyclosporin for purging multidrug-resistant leukemic cells from bone marrow in a mouse model. Experimental Hematology. 1992;20:1048-1054.
(1992)
Abstract
Kühl, JS; Sikic, BI; Blume, KG; Chao, NJ. Use of etoposide in combination with cyclosporine for purging multidrug resistant leukemic cells from bone marrow in a mouse model. Progress in Clinical and Biological Research. 1992;377:25-34.
(1992)
Abstract
Marie, JP; Brophy, NA; Ehsan, MN; Aihara, Y; Mohamed, NA; Cornbleet, J; Chao, NJ; Sikic, BI. Expression of multidrug resistance gene mdr1 mRNA in a subset of normal bone marrow cells. British Journal of Haematology. 1992;81:145-152.
(1992)
Abstract
Schmidt-Wolf, IG; Aihara, M; Negrin, RS; Blume, KG; Chao, NJ. In vitro and in vivo activity of murine lymphokine-activated killer cells after cryopreservation. Transfusion. 1992;32:42-45.
(1992)
Abstract
Aihara, M; Aihara, Y; Schmidt-Wolf, G; Schmidt-Wolf, I; Sikic, BI; Blume, KG; Chao, NJ. A combined approach for purging multidrug-resistant leukemic cell lines in bone marrow using a monoclonal antibody and chemotherapy. Blood. 1991;77:2079-2084.
(1991)
Abstract
Chao, NJ; Duncan, SR; Long, GD; Horning, SJ; Blume, KG. Corticosteroid therapy for diffuse alveolar hemorrhage in autologous bone marrow transplant recipients. Annals of Internal Medicine. 1991;114:145-146.
(1991)
Abstract
Chao, NJ; Forman, SJ; Schmidt, GM; Snyder, DS; Amylon, MD; Konrad, PN; Nademanee, AP; O'Donnell, MR; Parker, PM; Stein, AS. Allogeneic bone marrow transplantation for high-risk acute lymphoblastic leukemia during first complete remission. Blood. 1991;78:1923-1927.
(1991)
Abstract
Chao, NJ; Nademanee, AP; Long, GD; Schmidt, GM; Donlon, TA; Parker, P; Slovak, ML; Nagasawa, LS; Blume, KG; Forman, SJ. Importance of bone marrow cytogenetic evaluation before autologous bone marrow transplantation for Hodgkin's disease. Journal of Clinical Oncology. 1991;9:1575-1579.
(1991)
Abstract
Forman, SJ; Schmidt, GM; Nademanee, AP; Amylon, MD; Chao, NJ; Fahey, JL; Konrad, PN; Margolin, KA; Niland, JC; O'Donnell, MR. Allogeneic bone marrow transplantation as therapy for primary induction failure for patients with acute leukemia. Journal of Clinical Oncology. 1991;9:1570-1574.
(1991)
Abstract
Horning, SJ; Chao, NJ; Negrin, RS; Hoppe, RT; Kwak, LW; Long, GD; Stallbaum, B; O'Connor, P; Blume, KG. The Stanford experience with high-dose etoposide cytoreductive regimens and autologous bone marrow transplantation in Hodgkin's disease and non-Hodgkin's lymphoma: preliminary data. Annals of Oncology. 1991;2 Suppl 1:47-50.
(1991)
Abstract
Aihara, M; Sikic, BI; Blume, KG; Chao, NJ. Assessment of purging with multidrug resistance (MDR) modulators and VP-16: results of long-term marrow culture. Experimental Hematology. 1990;18:940-944.
(1990)
Abstract
Blume, KG; Schmidt, GM; Chao, NJ; Forman, SJ. Bone marrow transplantation from histocompatible sibling donors for patients with acute lymphoblastic leukemia. Haematology and blood transfusion. 1990;33:636-637.
(1990)
Abstract
Chao, NJ; Aihara, M; Blume, KG; Sikic, BI. Modulation of etoposide (VP-16) cytotoxicity by verapamil or cyclosporine in multidrug-resistant human leukemic cell lines and normal bone marrow. Experimental Hematology. 1990;18:1193-1198.
(1990)
Abstract
Chao, NJ; Amylon, MD; Long, GD; Negrin, RS; Hoppe, RT; Horning, SJ; Blume, KG. Bone marrow transplantation for hematologic malignancies: the Stanford experience. Clinical transplants. 1990;157-163.
(1990)
Abstract
Chao, NJ; Blume, KG. Bone marrow transplantation. Part II--autologous. Western Journal of Medicine. 1990;152:46-51.
(1990)
Abstract
Chao, NJ; Blume, KG. Bone marrow transplantation: what is the question?. Annals of Internal Medicine. 1990;113:340-341.
(1990)
Abstract
Chao, NJ; Rosenberg, SA; Horning, SJ. CEPP(B): an effective and well-tolerated regimen in poor-risk, aggressive non-Hodgkin's lymphoma. Blood. 1990;76:1293-1298.
(1990)
Abstract
Chao, NJ; Blume, KG. Bone marrow transplantation. Part I--Allogeneic. Western Journal of Medicine. 1989;151:638-643.
(1989)
Abstract
Chao, NJ; Timmerman, L; McDevitt, HO; Jacob, CO. Molecular characterization of MHC class II antigens (beta 1 domain) in the BB diabetes-prone and -resistant rat. Immunogenetics. 1989;29:231-234.
(1989)
Abstract
Schmidt-Wolf, IG; Aihara, M; Negrin, RS; Blume, KG; Chao, NJ. Lymphokine-activated killer cell activity after cryopreservation. Journal of Immunological Methods. 1989;125:185-189.
(1989)
Abstract
