Chief, Clinical Services
Department / Division
Medicine / Medicine-Pulmonary
Durham, NC 27710
Pulmonary-function testing, pulmonary rehabilitation, mechanical ventilation
1) Mechanical Ventilation and respiratory failure. Current projects involve studying patient-ventilator interactions during modes of support that require patient activity. The focus is on ventilatory muscle function during these assisted modes. Other projects include evaluating respiratory system mechanics in acute respiratory failure and the role of ECMO in the adult. Duke is also one of several institutions in the NIH ARDS Network, a consortium designed to perform multi-center trials.
2) Diffusing capacity of the lung for carbon monoxide. Current projects involve using a rapidly responding gas analyzer to measure lung diffusing capacity in discrete regions of the lung. These analyses are being extended into mechanically ventilated patients.
3) COPD. Current projects involve studying the physiology of cardio-respiratory conditioning in patients with obstructive lung disease and the role of pulmonary rehabilitation in improving COPD outcomes. Duke is also a member of two NIH sponsored multicenter programs: the COPDgene project correlating genetic profiles with physiologic/clinical phenotypes; and the NIH LOTT project evaluating the role of oxygen therapy in exercise and sleep hypoxemia.
4) Aerosol delivery systems. The current project is the development of a prototype aerosol generating catheter that can be directly inserted into the airways. Studies are being conducted in both ex vivo animal lungs and in mechanically ventilated patients.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Yang, LY; Huang, YC; Macintyre, NR. Patient-ventilator synchrony during pressure-targeted versus flow-targeted small tidal volume assisted ventilation. Journal of Critical Care. 2007;22:252-257. (2007) Abstract
Macintyre, N; Crapo, RO; Viegi, G; Johnson, DC; van der Grinten, CP; Brusasco, V; Burgos, F; Casaburi, R; Coates, A; Enright, P; Gustafsson, P; Hankinson, J; Jensen, R; McKay, R; Miller, MR; Navajas, D; Pedersen, OF; Pellegrino, R; Wanger, J. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. European Respiratory Journal. 2005;26:720-735. (2005) Abstract
Brower, RG; Lanken, PN; MacIntyre, N; Matthay, MA; Morris, A; Ancukiewicz, M; Schoenfeld, D; Thompson, BT; National Heart, Lung, and Blood Institute ARDS Clinical Trials Network. Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. New England Journal of Medicine. 2004;351:327-336. (2004) Abstract
Huang, YC; O'Brien, SR; MacIntyre, NR. Intrabreath diffusing capacity of the lung in healthy individuals at rest and during exercise. Chest. 2002;122:177-185. (2002) Abstract
MacIntyre, NR; Cook, DJ; Ely, EW; Epstein, SK; Fink, JB; Heffner, JE; Hess, D; Hubmayer, RD; Scheinhorn, DJ; American College of Chest Physicians, ; American Association for Respiratory Care, ; American College of Critical Care Medicine. Evidence-based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the American College of Chest Physicians; the American Association for Respiratory Care; and the American College of Critical Care Medicine. Chest. 2001;120:375S-395S. (2001) Abstract
MacIntyre, NR; Leatherman, NE. Ventilatory muscle loads and the frequency-tidal volume pattern during inspiratory pressure-assisted (pressure-supported) ventilation. American Review of Respiratory Disease. 1990;141:327-331. (1990) Abstract
MacIntyre, NR; Leatherman, NE. Mechanical loads on the ventilatory muscles. A theoretical analysis. American Review of Respiratory Disease. 1989;139:968-973. (1989) Abstract
MacIntyre, NR. Respiratory function during pressure support ventilation. Chest. 1986;89:677-683. (1986) Abstract
MacIntyre, NR; Leatherman, N; Deitz, JL; Wagoner, R; Friedman, M. Distribution and uptake of helium, carbon monoxide, and acetylene in the lungs during high frequency oscillatory ventilation. Respiration Physiology. 1986;63:201-212. (1986) Abstract