Physicians

Department / Division
Medicine / Medicine - Hematology

Address
DUMC 3912
Durham, NC 27710

Appointment Telephone
919-660-4363

Office Telephone
919-684-5350

Fax Telephone
919-681-6160

Training

• MD, Ege University Faculty of Medicine (Turkey), 1987

Residency

• Internal Medicine, State University of New York Downstate Medical Center, 1988-1991

Fellowship

• Hematology, Yale-New Haven Hospital (Connecticut), 1992-1995
• Medical Oncology, Yale-New Haven Hospital (Connecticut), 1997-1998

Clinical Interests
Consultative hematology, myeloproliferative neoplasms, bone marrow failure syndromes, multiple myeloma, myelodysplastic syndromes, rare hematologic disorders

Research Interests
Dr. Arcasoy's research interests include 1)The role of cytokines and cytokine receptors in hematopoietic commitment and lineage-specific differentiation 2) Mechanisms of tissue-specific expression of erythropoietin receptor (EPOR) gene and its role in lineage commitment and lineage-specific differentiation 3) Studies of the molecular basis of familial and congenital myeloproliferative disorders.4). Isolation of novel hematopoietic cytokine-responsive genes and study of their function and regulation 5). Characterization of novel non-hematopoietic functions of EPOR signaling

Dr. Arcasoy's laboratory has been studying the expression, regulation and function of the EPOR gene focusing on the function of naturally occuring mutations of the EPOR gene that result in primary familial and congenital polycythemia as well as the non-hematopoietic expression and functions of EPOR in vascular endothelium, macrophages, cardiac myocytes and cancer cells. We have also been studying global gene expression in erythroid cells from patients with polycythemia vera to better characterize the molecular signature of the disorder and develop new diagnostic tools.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Arcasoy, MO; Amin, K; Chou, SC; Haroon, ZA; Varia, M; Raleigh, JA. Erythropoietin and erythropoietin receptor expression in head and neck cancer: relationship to tumor hypoxia. Clinical Cancer Research. 2005;11:20-27. (2005) Abstract

Arcasoy, MO; Amin, K; Vollmer, RT; Jiang, X; Demark-Wahnefried, W; Haroon, ZA. Erythropoietin and erythropoietin receptor expression in human prostate cancer. Modern Pathology. 2005;18:421-430. (2005) Abstract

Arcasoy, MO; Chao, NJ. T-cell-mediated pure red-cell aplasia in systemic lupus erythematosus: response to cyclosporin A and mycophenolate mofetil. American Journal of Hematology. 2005;78:161-163. (2005) Abstract

Wang, L; Arcasoy, MO; Watowich, SS; Forget, BG. Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. Experimental Hematology. 2005;33:308-317. (2005) Abstract

Arcasoy, MO; Rockey, DC; Heneghan, MA. Pure red cell aplasia following pegylated interferon alpha treatment. American Journal of Medicine. 2004;117:619-620. (2004) Abstract

Collins, TS; Arcasoy, MO. Iron overload due to X-linked sideroblastic anemia in an African American man. American Journal of Medicine. 2004;116:501-502. (2004) Abstract

Wright, GL; Hanlon, P; Amin, K; Steenbergen, C; Murphy, E; Arcasoy, MO. Erythropoietin receptor expression in adult rat cardiomyocytes is associated with an acute cardioprotective effect for recombinant erythropoietin during ischemia-reperfusion injury. The FASEB Journal. 2004;18:1031-1033. (2004) Abstract

Arcasoy, MO; Jiang, X; Haroon, ZA. Expression of erythropoietin receptor splice variants in human cancer. Biochemical and Biophysical Research Communications. 2003;307:999-1007. (2003) Abstract

Haroon, ZA; Amin, K; Jiang, X; Arcasoy, MO. A novel role for erythropoietin during fibrin-induced wound-healing response. American Journal of Pathology. 2003;163:993-1000. (2003) Abstract

Arcasoy, MO; Karayal, AF; Segal, HM; Sinning, JG; Forget, BG. A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis. Blood. 2002;99:3066-3069. (2002) Abstract

Burns, S; Arcasoy, MO; Li, L; Kurian, E; Selander, K; Emanuel, PD; Harris, KW. Purification and characterization of the yeast-expressed erythropoietin mutant Epo (R103A), a specific inhibitor of human primary hematopoietic cell erythropoiesis. Blood. 2002;99:4400-4405. (2002) Abstract

Arcasoy, MO; Maun, NA; Perez, L; Forget, BG; Berliner, N. Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression. European Journal of Haematology. 2001;67:77-87. (2001) Abstract

Forget, BG; Degan, BA; Arcasoy, MO. Familial polycythemia due to truncations of the erythropoietin receptor. Transactions of the American Clinical and Climatological Association. 2000;111:38-44. (2000) Abstract

Arcasoy, MO; Gallagher, PG. Molecular diagnosis of hemoglobinopathies and other red blood cell disorders. Seminars in Hematology. 1999;36:328-339. (1999) Abstract

Arcasoy, MO; Harris, KW; Forget, BG. A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. Experimental Hematology. 1999;27:63-74. (1999) Abstract

Harris, KW; Hu, XJ; Schultz, S; Arcasoy, MO; Forget, BG; Clare, N. The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells. Blood. 1998;92:1219-1224. (1998) Abstract

Arcasoy, MO; Degar, BA; Harris, KW; Forget, BG. Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. Blood. 1997;89:4628-4635. (1997) Abstract

Arcasoy, MO; Romana, M; Fabry, ME; Skarpidi, E; Nagel, RL; Forget, BG. High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. Molecular and Cellular Biology. 1997;17:2076-2089. (1997) Abstract

Arcasoy, MO; Gallagher, PG. Hematologic disorders and nonimmune hydrops fetalis. Seminars in Perinatology. 1995;19:502-515. (1995) Abstract

Mookerjee, B; Arcasoy, MO; Atweh, GF. Spontaneous delta- to beta-globin switching in K562 human leukemia cells. Blood. 1992;79:820-825. (1992) Abstract

Luo, XN; Arcasoy, MO; Brickner, HE; Mistry, S; Schechter, AD; Atweh, GF. Regulated expression of p18, a major phosphoprotein of leukemic cells. Journal of Biological Chemistry. 1991;266:21004-21010. (1991) Abstract