Mitchell E. Horwitz, MD
Department / Division
Medicine /
Medicine - Cell Therapy and Hematologica
Address
DUMC 3961
Durham, NC 27710
Appointment Telephone
919-668-1027
Office Telephone
919-668-1045
Fax Telephone
919-668-1091
- MD, Rush Medical College of Rush University Medical Center (Illinois), 1992
- Internal Medicine, Northwestern University Medical Center (Illinois), 1995
- Hematology and Oncology, National Institutes of Health (Maryland), 1998
Clinical Interests
Autologous and allogeneic stem-cell transplantation for malignant and nonmalignant hematologic disorders; umbilical cord-blood transplantation
Research Interests
Allogeneic stem cell transplantation using umbilical cord blood grafts; Allogenic stem cell transplantation for Sickle Cell Disease; Prevention of acute graft versus host disease through donor stem cell graft manipulation; Improving immune recovery following alternative donor stem cell transplantation using donor graft manipulation or third party thymus transplantation.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
- Allos Therapeutics, Inc. (Spectrum Pharmaceuticals)
- Educational Concepts
- Gamida-Cell, Ltd.
- Genzyme Corporation (Sanofi Aventis)
- Gerson Lehrman Group, Inc.
- Guidepoint Global
- Otsuka
- Pfizer Inc.
Representative Publications
Roesler, J; Horwitz, ME; Picard, C; Bordigoni, P; Davies, G; Koscielniak, E; Levin, M; Veys, P; Reuter, U; Schulz, A; Thiede, C; Klingebiel, T; Fischer, A; Holland, SM; Casanova, JL; Friedrich, W. Hematopoietic stem cell transplantation for complete IFN-gamma receptor 1 deficiency: a multi-institutional survey. Journal of Pediatrics. 2004;145:806-812.
(2004)
Abstract
Yamashita, K; Choi, U; Woltz, PC; Foster, SF; Sneller, MC; Hakim, FT; Fowler, DH; Bishop, MR; Pavletic, SZ; Tamari, M; Castro, K; Barrett, AJ; Childs, RW; Illei, GG; Leitman, SF; Malech, HL; Horwitz, ME. Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells. Blood. 2004;103:3986-3988.
(2004)
Abstract
Horwitz, ME; Uzel, G; Linton, GF; Miller, JA; Brown, MR; Malech, HL; Holland, SM. Persistent Mycobacterium avium infection following nonmyeloablative allogeneic peripheral blood stem cell transplantation for interferon-gamma receptor-1 deficiency. Blood. 2003;102:2692-2694.
(2003)
Abstract
Horwitz, ME; Barrett, AJ; Brown, MR; Carter, CS; Childs, R; Gallin, JI; Holland, SM; Linton, GF; Miller, JA; Leitman, SF; Read, EJ; Malech, HL. Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft. New England Journal of Medicine. 2001;344:881-888.
(2001)
Abstract
Savage, WJ; Bleesing, JJ; Douek, D; Brown, MR; Linton, GM; Malech, HL; Horwitz, ME. Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows two patterns depending on age and donor/recipient chimerism. Bone Marrow Transplantation. 2001;28:463-471.
(2001)
Abstract
Horwitz, ME. Stem-cell transplantation for inherited immunodeficiency disorders. Pediatric Clinics of North America. 2000;47:1371-1387.
(2000)
Abstract
Horwitz, ME; Malech, HL; Anderson, SM; Girard, LJ; Bodine, DM; Orlic, D. Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA. Experimental Hematology. 1999;27:1160-1167.
(1999)
Abstract
