Department / Division:
Medicine / Cellular Therapy

Address:
DUMC 3961
Durham, NC 27710

Appointment Telephone:
919-668-1027

Office Telephone:
919-668-1045

Fax Telephone:
919-668-1091

• MD, Rush Medical College of Rush University Medical Center (Illinois), 1992

• Internal Medicine, Northwestern University Medical Center (Illinois), 1995

• Hematology and Oncology, National Institutes of Health (Maryland), 1998

Clinical Interests:
Autologous and allogeneic stem-cell transplantation for malignant and non-malignant hematologic disorders; umbilical cord-blood transplantation

Research Interests:
Allogeneic stem cell transplantation using umbilical cord blood grafts; Allogenic stem cell transplantation for Sickle Cell Disease; Prevention of acute graft versus host disease through donor stem cell graft manipulation; Improving immune recovery following alternative donor stem cell transplantation using donor graft manipulation or third party thymus transplantation.

Representative Publications:
Yamashita K, Choi U, Woltz PC, Foster SF, Sneller MC, Hakim FT, Fowler DH, Bishop MR, Pavletic SZ, Tamari M, Castro K, Barrett AJ, Childs RW, Illei GG, Leitman SF, Malech HL, Horwitz ME. Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells. Blood. 2004 May 15;103(10):3986-8. (2004) Abstract

Roesler J, Horwitz ME, Picard C, Bordigoni P, Davies G, Koscielniak E, Levin M, Veys P, Reuter U, Schulz A, Thiede C, Klingebiel T, Fischer A, Holland SM, Casanova JL, Friedrich W. Hematopoietic stem cell transplantation for complete IFN-gamma receptor 1 deficiency: a multi-institutional survey. J Pediatr. 2004 Dec;145(6):806-12. (2004) Abstract

Horwitz ME, Uzel G, Linton GF, Miller JA, Brown MR, Malech HL, Holland SM. Persistent Mycobacterium avium infection following nonmyeloablative allogeneic peripheral blood stem cell transplantation for interferon-gamma receptor-1 deficiency. Blood. 2003 Oct 1;102(7):2692-4. (2003) Abstract

Savage WJ, Bleesing JJ, Douek D, Brown MR, Linton GM, Malech HL, Horwitz ME. Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows two patterns depending on age and donor/recipient chimerism. Bone Marrow Transplant. 2001 Sep;28(5):463-71. (2001) Abstract

Horwitz ME, Barrett AJ, Brown MR, Carter CS, Childs R, Gallin JI, Holland SM, Linton GF, Miller JA, Leitman SF, Read EJ, Malech HL. Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft. N Engl J Med. 2001 Mar 22;344(12):881-8. (2001) Abstract

Horwitz ME. Stem-cell transplantation for inherited immunodeficiency disorders. Pediatr Clin North Am. 2000 Dec;47(6):1371-87. (2000) Abstract

Horwitz ME, Malech HL, Anderson SM, Girard LJ, Bodine DM, Orlic D. Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA. Exp Hematol. 1999 Jul;27(7):1160-7. (1999) Abstract