Department / Division
Medicine /
Medicine - Cell Therapy and Hematologica
Address
DUMC 3961
Durham, NC 27710
Appointment Telephone
919-668-1027
Office Telephone
919-668-1045
Fax Telephone
919-668-1091
Clinical Interests
Autologous and allogeneic stem-cell transplantation for malignant and nonmalignant hematologic disorders; umbilical cord-blood transplantation
Research Interests
Allogeneic stem cell transplantation using umbilical cord blood grafts; Allogenic stem cell transplantation for Sickle Cell Disease; Prevention of acute graft versus host disease through donor stem cell graft manipulation; Improving immune recovery following alternative donor stem cell transplantation using donor graft manipulation or third party thymus transplantation.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Representative Publications
Roesler, J; Horwitz, ME; Picard, C; Bordigoni, P; Davies, G; Koscielniak, E; Levin, M; Veys, P; Reuter, U; Schulz, A; Thiede, C; Klingebiel, T; Fischer, A; Holland, SM; Casanova, JL; Friedrich, W. Hematopoietic stem cell transplantation for complete IFN-gamma receptor 1 deficiency: a multi-institutional survey. Journal of Pediatrics. 2004;145:806-812.
(2004)
Abstract
Yamashita, K; Choi, U; Woltz, PC; Foster, SF; Sneller, MC; Hakim, FT; Fowler, DH; Bishop, MR; Pavletic, SZ; Tamari, M; Castro, K; Barrett, AJ; Childs, RW; Illei, GG; Leitman, SF; Malech, HL; Horwitz, ME. Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells. Blood. 2004;103:3986-3988.
(2004)
Abstract
Horwitz, ME; Uzel, G; Linton, GF; Miller, JA; Brown, MR; Malech, HL; Holland, SM. Persistent Mycobacterium avium infection following nonmyeloablative allogeneic peripheral blood stem cell transplantation for interferon-gamma receptor-1 deficiency. Blood. 2003;102:2692-2694.
(2003)
Abstract
Horwitz, ME; Barrett, AJ; Brown, MR; Carter, CS; Childs, R; Gallin, JI; Holland, SM; Linton, GF; Miller, JA; Leitman, SF; Read, EJ; Malech, HL. Treatment of chronic granulomatous disease with nonmyeloablative conditioning and a T-cell-depleted hematopoietic allograft. New England Journal of Medicine. 2001;344:881-888.
(2001)
Abstract
Savage, WJ; Bleesing, JJ; Douek, D; Brown, MR; Linton, GM; Malech, HL; Horwitz, ME. Lymphocyte reconstitution following non-myeloablative hematopoietic stem cell transplantation follows two patterns depending on age and donor/recipient chimerism. Bone Marrow Transplantation. 2001;28:463-471.
(2001)
Abstract
Horwitz, ME. Stem-cell transplantation for inherited immunodeficiency disorders. Pediatric Clinics of North America. 2000;47:1371-1387.
(2000)
Abstract
Horwitz, ME; Malech, HL; Anderson, SM; Girard, LJ; Bodine, DM; Orlic, D. Granulocyte colony-stimulating factor mobilized peripheral blood stem cells enter into G1 of the cell cycle and express higher levels of amphotropic retrovirus receptor mRNA. Experimental Hematology. 1999;27:1160-1167.
(1999)
Abstract
