Department / Division:
Anesthesiology / Anesthesiology

Address:
DUMC 3094
Durham, NC 27710

Office Telephone:
919-681-4781

Fax Telephone:
919-681-4776

• MD, Carol Davila University School of Medicine (Romania), 1993

• Anesthesiology, Yale University (Connecticut), 1996-2000

• Cardiothoracic Anesthesia, Duke University Medical Center, 2000-2002
• Critical Care Medicine, Duke University Medical Center, 2002-2003

Clinical Interests:
Cardiothoracic anesthesiology, critical care medicine, transesophageal echocardiography, genomic medicine, perioperative myocardial infarction, perioperative cardioprotection, perioperative systems medicine

Research Interests:
Basic-Translational:
1. Systems biology approaches to modeling perioperative cardiovascular injury and adaptation.
2. Mechanisms of perioperative myocardial injury; functional genomics applied to perioperative myocardial injury.
3. Metabolic consequences of perioperative myocardial ischemia-reperfusion injury.
4. Animal models and comparative genomic approaches to study perioperative myocardial ischemia-reperfusion injury.
5. Functional genomics of vein graft disease.
6. Animal models of vein graft disease.    
7. Genetic association studies in perioperative medicine.
8. Clinico-genomic risk prediction models for perioperative and long-term adverse cardiovascular outcomes following cardiac surgery.

Clinical:
9. Intraoperative quantification of tissue perfusion by contrast echocardiography.
10. Use of myocardial tissue deformation indices to characterize perioperative ventricular dysfunction/stunning
11. 3-D echocardiographic evaluation of the right ventricle

Representative Publications:
Turer AT, Stevens RD, Bain JR, Muehlbauer MJ, van der Westhuizen J, Mathew JP, Schwinn DA, Glower DD, Newgard CB, Podgoreanu MV. Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion. Circulation. 2009 Apr 7;119(13):1736-46. (2009) Abstract

de Lange F, Yoshitani K, Podgoreanu MV, Grocott HP, Mackensen GB. A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper. J Cardiothorac Surg. 2008;3:51. (2008) Abstract

Schwinn DA, Podgoreanu M. Pharmacogenomics and end-organ susceptibility to injury in the perioperative period. Best Pract Res Clin Anaesthesiol. 2008 Mar;22(1):23-37. (2008) Abstract

Phillips-Bute B, Mathew JP, Blumenthal JA, Morris RW, Podgoreanu MV, Smith M, Stafford-Smith M, Grocott HP, Schwinn DA, Newman MF, . Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery. Psychosom Med. 2008 Nov;70(9):953-9. (2008) Abstract

Swaminathan M, Morris RW, De Meyts DD, Podgoreanu MV, Jollis JG, Grocott HP, Milano CA, Newman MF, Mathew JP. Deterioration of regional wall motion immediately after coronary artery bypass graft surgery is associated with long-term major adverse cardiac events. Anesthesiology. 2007 Nov;107(5):739-45. (2007) Abstract

Mathew JP, Podgoreanu MV (co-first authors), Grocott HP, White WD, Morris RW, Stafford-Smith M, Mackensen GB, Rinder CS, Blumenthal JA, Schwinn DA, Newman MF,  . Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery.  J Am Coll Cardiol.  2007 May 15;49(19):1934-42. (2007) Abstract

Podgoreanu MV, White WD, Morris RW, Mathew JP, Stafford-Smith M, Welsby IJ, Grocott HP, Milano CA, Newman MF, Schwinn DA, . Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Circulation. 2006 Jul 4;114(1 Suppl):I275-81. (2006) Abstract

Welsby IJ, Podgoreanu MV (co-first authors), Phillips-Bute B, Mathew JP, Smith PK, Newman MF, Schwinn DA, Stafford-Smith M,  . Genetic factors contribute to bleeding after cardiac surgery.  J Thromb Haemost.  2005 Jun;3(6):1206-12. (2005) Abstract

Stafford-Smith M, Podgoreanu M(co-first authors), Swaminathan M, Phillips-Bute B, Mathew JP, Hauser EH, Winn MP, Milano C, Nielsen DM, Smith M, Morris R, Newman MF, Schwinn DA,  . Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery.  Am J Kidney Dis.  2005 Mar;45(3):519-30. (2005) Abstract

Schwinn DA, Podgoreanu M. The new age of medical genomics. Br J Anaesth. 2005 Aug;95(2):119-21. (2005) Abstract

Podgoreanu MV, Schwinn DA. New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics. J Am Coll Cardiol. 2005 Dec 6;46(11):1965-77. (2005) Abstract

Podgoreanu MV, Michelotti GA, Sato Y, Smith MP, Lin S, Morris RW, Grocott HP, Mathew JP, Schwinn DA. Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes.  J Thorac Cardiovasc Surg.  2005 Aug;130(2):330-9. (2005) Abstract

Podgoreanu MV, Mathew JP. Genomic basis of perioperative medicine, In: Barash P, Cullen B, Stoelting RK eds. Clinical Anesthesia 5th edition, 2005, pp.133-148. (2005)

Moretti EW, Morris RW, Podgoreanu M, Schwinn DA, Newman MF, Bennett E, Moulin VG, Mba UU, Laskowitz DT, . APOE polymorphism is associated with risk of severe sepsis in surgical patients. Crit Care Med. 2005 Nov;33(11):2521-6. (2005) Abstract

Grocott HP, White WD, Morris RW, Podgoreanu MV, Mathew JP, Nielsen DM, Schwinn DA, Newman MF,  . Genetic polymorphisms and the risk of stroke after cardiac surgery.  Stroke.  2005 Sep;36(9):1854-8. (2005) Abstract

Podgoreanu MV, Schwinn DA. Genomics and the circulation. Br J Anaesth. 2004 Jul;93(1):140-8. (2004) Abstract

Podgoreanu MV, Stout RG, El-Moalem HE, Silverman DG. Synchronous rhythmical vasomotion in the human cutaneous microvasculature during nonpulsatile cardiopulmonary bypass. Anesthesiology. 2002 Nov;97(5):1110-7. (2002) Abstract