Physicians

Department / Division
Anesthesiology / Anesthesiology-Cardiac Division

Address
DUMC 3094
Durham, NC 27710

Office Telephone
919-681-4781

Fax Telephone
919-681-4776

Training

• MD, Carol Davila University School of Medicine and Pharmacy (Romania), 1993

Residency

• Anesthesiology, Yale University (Connecticut), 1996-2000

Fellowship

• Cardiothoracic Anesthesia, Duke University Medical Center, 2000-2002
• Critical Care Medicine, Duke University Medical Center, 2002-2003

Clinical Interests
Cardiothoracic anesthesiology, critical care medicine, transesophageal echocardiography, genomic medicine, perioperative myocardial infarction, perioperative cardioprotection, perioperative systems medicine

Research Interests
Basic-Translational:
1. Systems biology approaches to modeling perioperative cardiovascular injury and adaptation.
2. Mechanisms of perioperative myocardial injury; functional genomics applied to perioperative myocardial injury.
3. Metabolic consequences of perioperative myocardial ischemia-reperfusion injury.
4. Animal models and comparative genomic approaches to study perioperative myocardial ischemia-reperfusion injury.
5. Functional genomics of vein graft disease.
6. Animal models of vein graft disease.
7. Genetic association studies in perioperative medicine.
8. Clinico-genomic risk prediction models for perioperative and long-term adverse cardiovascular outcomes following cardiac surgery.

Clinical:
9. Intraoperative quantification of tissue perfusion by contrast echocardiography.
10. Use of myocardial tissue deformation indices to characterize perioperative ventricular dysfunction/stunning
11. 3-D echocardiographic evaluation of the right ventricle

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Turer, AT; Stevens, RD; Bain, JR; Muehlbauer, MJ; van der Westhuizen, J; Mathew, JP; Schwinn, DA; Glower, DD; Newgard, CB; Podgoreanu, MV. Metabolomic profiling reveals distinct patterns of myocardial substrate use in humans with coronary artery disease or left ventricular dysfunction during surgical ischemia/reperfusion. Circulation. 2009;119:1736-1746. (2009) Abstract

Phillips-Bute, B; Mathew, JP; Blumenthal, JA; Morris, RW; Podgoreanu, MV; Smith, M; Stafford-Smith, M; Grocott, HP; Schwinn, DA; Newman, MF; Perioperative Genetics and Safety Outcomes Investigative Team. Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery. Psychosomatic Medicine. 2008;70:953-959. (2008) Abstract

Schwinn, DA; Podgoreanu, M. Pharmacogenomics and end-organ susceptibility to injury in the perioperative period. Bailliere's Best Practice and Research in Clinical Anaesthesiology. 2008;22:23-37. (2008) Abstract

de Lange, F; Yoshitani, K; Podgoreanu, MV; Grocott, HP; Mackensen, GB. A novel survival model of cardioplegic arrest and cardiopulmonary bypass in rats: a methodology paper. Journal of Cardiothoracic Surgery. 2008;3:51. (2008) Abstract

Mathew, JP; Podgoreanu, MV; Grocott, HP; White, WD; Morris, RW; Stafford-Smith, M; Mackensen, GB; Rinder, CS; Blumenthal, JA; Schwinn, DA; Newman, MF; PEGASUS Investigative Team. Genetic variants in P-selectin and C-reactive protein influence susceptibility to cognitive decline after cardiac surgery. Journal of the American College of Cardiology. 2007;49:1934-1942. (2007) Abstract

Swaminathan, M; Morris, RW; De Meyts, DD; Podgoreanu, MV; Jollis, JG; Grocott, HP; Milano, CA; Newman, MF; Mathew, JP. Deterioration of regional wall motion immediately after coronary artery bypass graft surgery is associated with long-term major adverse cardiac events. Anesthesiology. 2007;107:739-745. (2007) Abstract

Podgoreanu, MV; White, WD; Morris, RW; Mathew, JP; Stafford-Smith, M; Welsby, IJ; Grocott, HP; Milano, CA; Newman, MF; Schwinn, DA; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. Circulation. 2006;114:I275-I281. (2006) Abstract

Grocott, HP; White, WD; Morris, RW; Podgoreanu, MV; Mathew, JP; Nielsen, DM; Schwinn, DA; Newman, MF; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Genetic polymorphisms and the risk of stroke after cardiac surgery. Stroke. 2005;36:1854-1858. (2005) Abstract

Moretti, EW; Morris, RW; Podgoreanu, M; Schwinn, DA; Newman, MF; Bennett, E; Moulin, VG; Mba, UU; Laskowitz, DT; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. APOE polymorphism is associated with risk of severe sepsis in surgical patients. Critical Care Medicine. 2005;33:2521-2526. (2005) Abstract

Podgoreanu, MV; Michelotti, GA; Sato, Y; Smith, MP; Lin, S; Morris, RW; Grocott, HP; Mathew, JP; Schwinn, DA. Differential cardiac gene expression during cardiopulmonary bypass: ischemia-independent upregulation of proinflammatory genes. Journal of Thoracic and Cardiovascular Surgery. 2005;130:330-339. (2005) Abstract

Podgoreanu, MV; Schwinn, DA. New paradigms in cardiovascular medicine: emerging technologies and practices: perioperative genomics. Journal of the American College of Cardiology. 2005;46:1965-1977. (2005) Abstract

Schwinn, DA; Podgoreanu, M. The new age of medical genomics. British Journal of Anaesthesia. 2005;95:119-121. (2005) Abstract

Stafford-Smith, M; Podgoreanu, M; Swaminathan, M; Phillips-Bute, B; Mathew, JP; Hauser, EH; Winn, MP; Milano, C; Nielsen, DM; Smith, M; Morris, R; Newman, MF; Schwinn, DA; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery. American Journal of Kidney Diseases. 2005;45:519-530. (2005) Abstract

Welsby, IJ; Podgoreanu, MV; Phillips-Bute, B; Mathew, JP; Smith, PK; Newman, MF; Schwinn, DA; Stafford-Smith, M; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. Genetic factors contribute to bleeding after cardiac surgery. Journal of Thrombosis and Haemostasis. 2005;3:1206-1212. (2005) Abstract

Podgoreanu, MV; Schwinn, DA. Genomics and the circulation. British Journal of Anaesthesia. 2004;93:140-148. (2004) Abstract

Podgoreanu, MV; Stout, RG; El-Moalem, HE; Silverman, DG. Synchronous rhythmical vasomotion in the human cutaneous microvasculature during nonpulsatile cardiopulmonary bypass. Anesthesiology. 2002;97:1110-1117. (2002) Abstract