Department / Division:
Radiology / Nuclear Medicine

Address:
DUMC 3949
Durham, NC 27710

Appointment Telephone:
919-684-7647

Office Telephone:
919-684-7619

Fax Telephone:
919-684-7167

• MD, West Virginia University School of Medicine, 1974

• Internal Medicine/Cardiovascular, Riverside Methodist Hospital (Ohio), 1974-1977, 1977-1979

• Nuclear Medicine, Duke University Medical Center, 1987-1989

Clinical Interests:
Cardiovascular nuclear imaging, myocardial perfusion and functional imaging (first-pass RNA and MuGA) with conventional radionuclides, myocardial perfusion and metabolic imaging with PET, exercise and pharmacologic stress testing

Research Interests:
Current research efforts within the Division of Nuclear Medicine in the Department of Radiology include the following:

1. Assessment of myocardial viability prior to myocardial revascularization in patients with coronary artery disease and a low left ventricular ejection fraction by means of a resting N-13 Ammonia myocardial perfusion scan followed by a resting and, subsequently, an exercise F-18 FDG myocardial metabolism scan.

2. Quantitative assessment of absolute coronary artery blood flow at rest and following the infusion of intravenous dipyridamole in patients with non-ischemic cardiomyopathy.

3. Evaluation of left ventricular function, assessed by MUGA studies, before and after therapy with antidepressants in patients with coronary artery disease and recent myocardial infarction.

4.   Evaluation of attenuation correction programs in myocardial perfusion SPECT imaging.

Representative Publications:
7. Hanson MW, Morris EL, Borges-Neto S, DeLong DM: Analysis of cardia arrhythmias during dobutamine pharmacologic stress testing in nuclear cardiology as related to the presence or absence of baseline arrhythmias. J Nucl Cardiol 4(5): 372-278, 1997. (1997)

6. DeGrado TR, Hanson MW, Turkington TG, DeLong DM, Brezinski DA, Vallee JP, Hedlund LW, Zhang J, Cobb F, Sullivan JF, Coleman RE: Estimation of myocardial blood flow for longitudinal studies with N-13 labeled ammonia and positron emission tomography. J Nucl Cardiol 3(6): 494-507, 1996. (1996)

5. Brezinski DA, Harrison JK, Hanson MW, Wilson JS, VanTright P, Bashore TM. Ischemic Hibernating Myocardium Demonstrated by Positron Emission Tomography in Anomalous Origin of the Left Coronary Artery from the Pulmonary Artery. Am Heart Jour. 128(1):181-185, 1994. (1994)

4. Borges-Neto S, Puma J, Jones RH, Sketch MH, Stack R, Hanson MW, Coleman RE. Myocardial Perfusion and Ventricular Function Measurements During Total Coronary Artery Occlusion in Humans: A Comparison with Rest and Exercise Radionuclide Studies. Circulation. 89(1): 278-284, 1994. (1994)

3. Lowe VJ, Greer KL, Hanson MW, Jaszczak RJ, Coleman RE. Cardiac Phantom Evaluation of Simultaneously Acquired Dual-Isotope Rest Thallium-201/Stress Technetium 99-m SPECT Imaging. J Nucl Med. 34911): 1998-20069, 1993. (1993)

2. Hoffman JM, Hanson MW, Coleman RE. Clinical Positron Emission Tomography Imaging - Applications in Cardiology. Radiologic Clinics of North America. 31(4): 935-959, 1993. (1993)

1. Berry JJ, Hoffman JM, Steenbergen C, Baker JA, Floyd C, VanTright P, Hanson MW, Coleman RE. Human Pathologic Correlation with PET in Ischemic and Non-Ischemic Cardiomyopathy. J Nucl Med 34(1): 39-47, 1993. (1993)