Physicians

Departments / Divisions

• Anesthesiology / Anesthesiology-Neuro Division
• Medicine / Medicine-Neurology

Address
DUMC 3094
Durham, NC 27710

Office Telephone
919-681-6472

Fax Telephone
919-681-4698

Training

• MD, Louisiana State University School of Medicine–New Orleans, 1999

Residency

• Internal Medicine, Duke University Medical Center, 2000
• Neurology, Duke University Medical Center, 2003
• Anesthesiology, Duke University Medical Center, 2006

Fellowship

• Neurocritical Care, Duke University Medical Center, 2006

Other Training

• Subspecialty Certification, Vascular Neurology
• Certification, Neurovascular Ultrasound

Clinical Interests
Neurocritical care; neuroanesthesia for neurosurgical procedures; research interests in intracerebral hemorrhage including mouse modeling, developing strategies for intraoperative neural monitoring

Research Interests
translational acute CNS injury
murine models of intracerebral hemorrhage, traumatic brain injury, ischemic stroke, and subarachnoid hemorrhage
gender-bias and sex differences in recovery from intracerebral hemorrhage
neuroinflammatory mechanisms of acute CNS injury
novel therapeutics in neurologic intensive care
proteogenomic and epigenetic profiles after intracerebral hemorrhage

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Wang, H; Anderson, LG; Lascola, CD; James, ML; Venkatraman, TN; Bennett, ER; Acheson, SK; Vitek, MP; Laskowitz, DT. ApolipoproteinE mimetic peptides improve outcome after focal ischemia. Experimental Neurology. 2013;241:67-74. (2013) Abstract

Indraswari, F; Wang, H; Lei, B; James, ML; Kernagis, D; Warner, DS; Dawson, HN; Laskowitz, DT. Statins improve outcome in murine models of intracranial hemorrhage and traumatic brain injury: a translational approach. Journal of Neurotrauma. 2012;29:1388-1400. (2012) Abstract

James, ML; Wang, H; Cantillana, V; Lei, B; Kernagis, DN; Dawson, HN; Klaman, LD; Laskowitz, DT. TT-301 inhibits microglial activation and improves outcome after central nervous system injury in adult mice. Anesthesiology. 2012;116:1299-1311. (2012) Abstract

Laskowitz, DT; Lei, B; Dawson, HN; Wang, H; Bellows, ST; Christensen, DJ; Vitek, MP; James, ML. The apoE-mimetic peptide, COG1410, improves functional recovery in a murine model of intracerebral hemorrhage. Neurocritical Care. 2012;16:316-326. (2012) Abstract

Sheng, SP; Lei, B; James, ML; Lascola, CD; Venkatraman, TN; Jung, JY; Maze, M; Franks, NP; Pearlstein, RD; Sheng, H; Warner, DS. Xenon neuroprotection in experimental stroke: interactions with hypothermia and intracerebral hemorrhage. Anesthesiology. 2012;117:1262-1275. (2012) Abstract

Sun, W; Peacock, A; Becker, J; Phillips-Bute, B; Laskowitz, DT; James, ML. Correlation of leukocytosis with early neurological deterioration following supratentorial intracerebral hemorrhage. Journal of Clinical Neuroscience. 2012;19:1096-1100. (2012) Abstract

James, ML; Wang, H; Venkatraman, T; Song, P; Lascola, CD; Laskowitz, DT. Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice. Journal of Neurotrauma. 2010;27:217-228. (2010) Abstract

James, ML; Blessing, R; Bennett, E; Laskowitz, DT. Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans. Journal of Stroke and Cerebrovascular Diseases. 2009;18:144-149. (2009) Abstract

James, ML; Blessing, R; Phillips-Bute, BG; Bennett, E; Laskowitz, DT. S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage. Biomarkers. 2009;14:388-394. (2009) Abstract

James, ML; Sullivan, PM; Lascola, CD; Vitek, MP; Laskowitz, DT. Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. Stroke. 2009;40:632-639. (2009) Abstract

James, ML; Warner, DS; Laskowitz, DT. Preclinical models of intracerebral hemorrhage: a translational perspective. Neurocritical Care. 2008;9:139-152. (2008) Abstract