Physicians

Departments / Divisions

• Anesthesiology / Anesthesiology-Neuro Division
• Medicine / Medicine-Neurology

Address
DUMC 3094
Durham, NC 27710

Office Telephone
919-681-6472

Fax Telephone
919-681-4698

Training

• MD, Louisiana State University School of Medicine in New Orleans, 1999

Residency

• Internal Medicine, Duke University Medical Center, 2000
• Neurology, Duke University Medical Center, 2003
• Anesthesiology, Duke University Medical Center, 2006

Fellowship

• Neurocritical Care, Duke University Medical Center, 2006

Other Training

• Subspecialty Certification, Vascular Neurology
• Certification, Neurovascular Ultrasound

Clinical Interests
Neurocritical care; neuroanesthesia for neurosurgical procedures; research interests in intracerebral hemorrhage including mouse modeling and developing strategies for intraoperative neural monitoring

Research Interests
translational acute CNS injury
murine models of traumatic brain injury, ischemic stroke, subarachnoid hemorrhage, and intracerebral hemorrhage
intraoperative neurophysiologic monitoring
gender-bias in acute CNS injury
neuroinflammatory mechanisms of acute CNS injury
novel therapeutics in neurologic intensive care
proteogenomic patterns after acute CNS injury

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Hospira, Inc.
• Medivance, Inc.
• The Medicines Company
• UCB Pharma

Representative Publications
James ML, Wang H, Venkatraman T, Song P, Lascola CD, Laskowitz DT. Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice. J Neurotrauma. 2010 Jan;27(1):217-28. (2010) Abstract

James ML, Blessing R, Bennett E, Laskowitz DT. Apolipoprotein E modifies neurological outcome by affecting cerebral edema but not hematoma size after intracerebral hemorrhage in humans. J Stroke Cerebrovasc Dis. 2009 Mar-Apr;18(2):144-9. (2009) Abstract

James ML, Blessing R, Phillips-Bute BG, Bennett E, Laskowitz DT. S100B and brain natriuretic peptide predict functional neurological outcome after intracerebral haemorrhage. Biomarkers. 2009 Sep;14(6):388-94. (2009) Abstract

James ML, Sullivan PM, Lascola CD, Vitek MP, Laskowitz DT. Pharmacogenomic effects of apolipoprotein e on intracerebral hemorrhage. Stroke. 2009 Feb;40(2):632-9. (2009) Abstract

James ML, Warner DS, Laskowitz DT. Preclinical models of intracerebral hemorrhage: a translational perspective. Neurocrit Care. 2008;9(1):139-52. (2008) Abstract