Physicians

Department / Division
Pediatrics / Pediatrics-Hematology/Oncology

Address
DUMC 102382
Durham, NC 27710

Appointment Telephone
919-684-3401

Office Telephone
919-684-3401

Fax Telephone
919-681-7950

Training

• MD, University of Minnesota Medical School, 2001

Residency

• Pediatrics, University of Michigan Medical Center, 2001-2003

Fellowship

• Pediatric Hematology-Oncology, University of Michigan, 2003-2006

Other Training

• PhD, Biochemistry, Biophysics, and Molecular Biology, University of Minnesota, 1999

Clinical Interests
Advanced treatments for neuroblastoma, pediatric solid tumors, leukemia

Research Interests
Neuroblastoma is the most common extra-cranial solid tumor of childhood. Despite advances in the treatment of childhood cancer, outcomes for children with advanced-stage neuroblastoma remain poor. My basic science research interests are focused on understanding the physiology of the neuroblastoma cell and what it does to circumvent the effects of chemotherapy. Additionally, I am interested in translational research in neuroblastoma. We have open trials for therapeutic MIBG and anti-GD2 antibody treatment for neuroblastoma. Clinically, I am involved in the treatment of childhood malignancies including neuroblasotma, soft tissue sarcomas, and leukemia. Additionally, I have an interest in the management of vascular malformations, such as hemangioma.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Armstrong, MB; Schumacher, KR; Mody, R; Yanik, GA; Opipari, AW; Castle, VP. Bortezomib as a therapeutic candidate for neuroblastoma. Journal of Experimental Therapeutics and Oncology. 2008;7:135-145. (2008) Abstract

Armstrong, MB; Bian, X; Liu, Y; Subramanian, C; Ratanaproeksa, AB; Shao, F; Yu, VC; Kwok, RP; Opipari, AW; Castle, VP. Signaling from p53 to NF-kappaB determines the chemotherapy responsiveness of neuroblastoma. Neoplasia. 2006;8:967-977. (2006) Abstract

Armstrong, MB; Robertson, PL; Castle, VP. Delayed, recurrent opsoclonus-myoclonus syndrome responding to plasmapheresis. Pediatric Neurology. 2005;33:365-367. (2005) Abstract