Department / Division:
Medicine / Cardiology

Address:
DUMC 3126
Durham, NC 27710

Appointment Telephone:
919-681-5816

Office Telephone:
919-681-3945

Fax Telephone:
919-668-1380

• MD, University of California, San Francisco, School of Medicine, 1987

• Internal Medicine, University of California, San Francisco Medical Center, 1987-1990
• Cardiology, Duke University Medical Center, 1991-1995

Clinical Interests:
General cardiology, secondary prevention, lipids, heart failure

Research Interests:
General focus: My research interests are in primary and secondary prevention of cardiovascular disease. Specifically, I am looking at compliance issues within the cardiology division and in the University as a whole with regard to evidence based treatment and secondary prevention of cardiovascular disease. I am using both retrospective and prospective collection of discharge data to try and analyze these trends. In the future, we hope to begin clinical trials with regard to various issues which are outstanding in primary and secondary prevention. Some of the issues include treatment of hypercholesterolemia in elderly patients, differences between the various statins with regard to affects on lipid profiles, and early treatment of hypercholesterolemia after MI.

As part of my work, I have served as a consultant with various drug companies with regard to focusing on active issues and treatment of hypercholesterolemia.

Key words: Primary prevention, secondary prevention, hyperlipidemia, homocysteine, and hypertension.

Representative Publications:
Channon, K.M., Kypson, A.P., Daggett, C.W., Blazing, M.A., Koch, W.J., George, S.E. Enhanced pulmonary nitric oxide production and vasomotor function after in vivo pulmonary artery denoviral gene transfer of nitric oxide synthase. European Society of Cardiology. (1997). (1997)

Channon, K.M., Fulton, G.J., Betty, G.A., Annex, B.H., Blazing, M.A., Hagen, P-O, George, S.E.: Adenoviral gene transfer to venous bypass grafts. Circulation, 1996. (submitted) (1996)

Channon, K.M., Blazing, M.A., George, S.E.: Vascular gene transfer. Brit. Heart J. 1996. (in press) Channon, K.M., Blazing, M.A., Potts, K.E., Shetty, G.A., George, S.E.: Adenoviral gene transfer of nitric oxide synthase: high level expression in human vascular cells. Human Gene therapy. (submitted) (1996)

Davies, M.G., Annex, B.A., Channon, K.M., Denning, S.M., Taylor, D.A., Blazing, M.A., Fulton, G.J., Peters, K.G., George, S.E., Hagen, P-O: Alterations of arterial vasomotor function by gene transfer with a replication-deficient adenovirus. (submitted)