Mary Foster, MD
Department / Division
Medicine /
Medicine-Nephrology
Research Interests
Research in the Foster Lab focuses on autoimmune glomerulonephritis, a
major cause of acute and chronic kidney disease worldwide.
Our experiments explore the origins and regulation of the pathogenic immune
responses that underlie glomerulonephritis, and are designed to: identify
tolerance mechanisms that regulate nephritogenic lymphocytes, with an emphasis
on B cells and autoantibodies; determine the molecular basis of tolerance;
identify defects in immune regulation and the contributions of genetic autoimmune
predisposition; and identify environmental disease triggers. These experiments use novel
models relevant to immune nephritis in both kidney-restricted and systemic autoimmunity
(Goodpasture syndrome and systemic lupus erythematosus, respectively), that are amenable to
mechanistic dissection using basic immunological, molecular biological, and
proteomics approaches. An ultimate goal is to advance novel diagnostic and therapeutic
approaches to improve the lives of patients.
This faculty member has no reported relationships with industry.
Representative Publications
Clark AG, Mackin KM, Foster MH. Tracking Differential Gene Expression in MRL/MpJ Versus C57BL/6 Anergic B Cells: Molecular Markers of Autoimmunity. Biomark Insights. 2008;3:335-350.
(2008)
Abstract
Foster MH. Novel targets for immunotherapy in glomerulonephritis. Biologics. 2008 Sep;2(3):531-45.
(2008)
Abstract
Zhang Y, Su SC, Hecox DB, Brady GF, Mackin KM, Clark AG, Foster MH. Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. J Immunol. 2008 Nov 1;181(9):6092-100.
(2008)
Abstract
Clark AG, Chen S, Zhang H, Brady GF, Ungewitter EK, Bradley JK, Sackey FN, Foster MH. Multifunctional regulators of cell growth are differentially expressed in anergic murine B cells. Mol Immunol. 2007 Feb;44(6):1274-85.
(2007)
Abstract
Foster MH. T cells and B cells in lupus nephritis. Semin Nephrol. 2007 Jan;27(1):47-58.
(2007)
Abstract
Foster MH, Zhang Y, Clark AG. Deconstructing B cell tolerance to basement membranes. Arch Immunol Ther Exp (Warsz). 2006 Jul-Aug;54(4):227-37.
(2006)
Abstract
Brady GF, Congdon KL, Clark AG, Sackey FN, Rudolph EH, Radic MZ, Foster MH. Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig. J Immunol. 2004 May 1;172(9):5313-21.
(2004)
Abstract
Rudolph EH, Congdon KL, Sackey FN, Fitzsimons MM, Foster MH. Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors. J Immunol. 2002 Jun 1;168(11):5943-53.
(2002)
Abstract
Cooperstone B. G., M. M. Rahman, E. H. Rudolph and M. H. Foster. In vitro and In vivo expression of a nephritogenic Ig heavy chain determinant: Pathogenic autoreactivity requires permissive light chains. Immunol Cell Biol, 79:222-230, 2001.
(2001)
Foster M. H. Immunologic Renal Disease. In Samter's Immunologic Diseases (6th edition), K. F. Austen, M. M. Frank, J. P. Atkinson and H. Cantor, ed. , Lippincott Williams and Wilkins, Baltimore, 2001.
(2001)
Foster M. H. Relevance of systemic lupus erythematosus (SLE) nephritis animal models to human disease. Semin Nephrol 19(1): 12-24, 1999.
(1999)
Fitzsimons MM, Foster MH. The nephritogenic immune response. Curr Opin Nephrol Hypertens. 1997 May;6(3):267-75.
(1997)
Abstract
Foster MH, Kieber-Emmons T, Ohliger M, Madaio MP. Molecular and structural analysis of nuclear localizing anti-DNA lupus antibodies. Immunol Res. 1994;13(2-3):186-206.
(1994)
Abstract
Foster MH, Sabbaga J, Line SR, Thompson KS, Barrett KJ, Madaio MP. Molecular analysis of spontaneous nephrotropic anti-laminin antibodies in an autoimmune MRL-lpr/lpr mouse. J Immunol. 1993 Jul 15;151(2):814-24.
(1993)
Abstract
Foster MH, MacDonald M, Barrett KJ, Madaio MP. VH gene analysis of spontaneously activated B cells in adult MRL-lpr/lpr mice. J558 bias is not limited to classic lupus autoantibodies. J Immunol. 1991 Sep 1;147(5):1504-11.
(1991)
Abstract
