Chair, Department of MedicineDepartments / Divisions
Durham, NC 27710
General infectious diseases, HIV, infections in immuno-compromised hosts
An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection. Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, and, most recently, to develop topical microbicides that could be used to block sexual transmission of HIV.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Blasi, M; Negri, D; Santra, S; Parks, R; Shen, X; Tomaras, G; Permar, S; Montefiori, D; LaBranche, C; Ferrari, G; Alam, M; Liao, H; Moody, AM; Haynes, BF; Klotman, ME; Cara, A. A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys. AIDS Research and Human Retroviruses. A161-A161. (2013)
Hutter, R; Huang, L; Speidl, WS; Giannarelli, C; Trubin, P; Bauriedel, G; Klotman, ME; Fuster, V; Badimon, JJ; Klotman, PE. Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma. Circulation. 2013;128:2351-2363. (2013) Abstract
Micsenyi, AM; Zony, C; Alvarez, RA; Durham, ND; Chen, BK; Klotman, ME. Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells. Journal of Infectious Diseases. 2013;208:1756-1767. (2013) Abstract
Todd, RF; Salata, RA; Klotman, ME; Weisfeldt, ML; Katz, JT; Xian, SX; Hearn, DP; Lipner, RS. Career outcomes of the graduates of the American Board of Internal Medicine Research Pathway, 1995-2007. Academic Medicine. 2013;88:1747-1753. (2013) Abstract
Blasi, M; Rossi, A; Michelini, Z; Leone, P; Perretta, G; Cimarelli, A; Klotman, ME; Negri, D; Cara, A. Simian immunodeficiency virus-Vpx as an adjuvant for integrase defective lentiviral vector-based vaccines. Retrovirology. 2012;9. (2012)
Negri, DR; Rossi, A; Blasi, M; Michelini, Z; Leone, P; Chiantore, MV; Baroncelli, S; Perretta, G; Cimarelli, A; Klotman, ME; Cara, A. Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines. Retrovirology. 2012;9:69. (2012) Abstract
Chen, P; Chen, BK; Mosoian, A; Hays, T; Ross, MJ; Klotman, PE; Klotman, ME. Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells. Journal of the American Society of Nephrology. 2011;22:496-507. (2011) Abstract
Ding, J; Rapista, A; Teleshova, N; Lu, W; Klotman, ME; Chang, TL. Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides. Journal of Innate Immunity. 2011;3:208-212. (2011) Abstract
Jao, J; Palmer, D; Leus, I; Tih, P; Baweja, M; Klotman, M; Sperling, R; Wyatt, C. Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon. Nephrology Dialysis Transplantation. 2011;26:3051-3053. (2011)
Papeta, N; Kiryluk, K; Patel, A; Sterken, R; Kacak, N; Snyder, HJ; Imus, PH; Mhatre, AN; Lawani, AK; Julian, BA; Wyatt, RJ; Novak, J; Wyatt, CM; Ross, MJ; Winston, JA; Klotman, ME; Cohen, DJ; Appel, GB; D'Agati, VD; Klotman, PE; Gharavi, AG. APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. Journal of the American Society of Nephrology. 2011;22:1991-1996. (2011) Abstract