Physicians

Department / Division
Medicine / Medicine-Pulmonary

Address
DUMC 102352
Durham, NC 27710

Appointment Telephone
919-684-2240

Office Telephone
919-684-6140

Fax Telephone
919-684-3067

Training

• MD, University of Illinois College of Medicine, 1982

Residency

• Internal Medicine, University of Illinois Hospital, 1982-1985
• Medicine, University of Illinois Hospital, 1986
• Pulmonary/Critical Care Medicine, Boston University (Massachusetts), 1986-1990

Clinical Interests
Pulmonary fibrosis, interstitial lung diseases, lung transplantation

Research Interests
The general focus of my research interests are  1)new treatments for fibrotic lung diseases, 2) and understanding the genetic basis of pulmonary fibrosis, and 3)development of novel biomarkers for the diagnosis and prognosis of interest are idiopathic intersitial pneumonias.  I am involved in Industry-based and NIH/DCRI-based clinical trials in IPF, and NIH sponsored research on the genomics and genetics of pulmonary fibrosis.  I am PI at Duke and collaborating with investigators at National Jewish Health, U. Colorado, and Vanderbilt on a linkage and  genome-wide association studies in familial pulmonary fibrosis. We have an extensive clinical database and DNA repository on over 500 families.  We have identified several candidate loci and genes in these areas of linkage are being investigated for disease-susceptability mutations, and we have identified risk variants in the mucin genes.  We are using gene expression analysis on peripheral blood and lung to identifiy biomarkers.  

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• cooper and scully pc
• hinshaw and culbertson llp

Representative Publications
Steele, MP, Noble P.  Genetics, Genomics, and Proteomics in Interstitial Lung Disease In Genomic Medicine. Geoffrey Ginsburg, Eds, Blackwell Press,  2009 (2009)

Suthy SJ, Martinu T, Youens K, Lawrence CM, Howell D, Palmer SM, Steele MP.  Symptomatic Pulmonary Kaposi’s Sarcoma in Two Lung Transplant Recipients.  Am J Transplantation, 8:1951-1956, 2008 (2008)

Hadjiliadis, D, Steele MP, Chaparro C, Singer LG, Waddell TK, Hutcheon MA, Davis RD, Palmer SM.  Survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than Burkholderia cepacia, compared with patients harboring sensitive bacteria.  J. Heart and Lung Transplantation. 26(8):834-838, 2007. (2007)

Yang Ivana V, Burch Lauranell H, Steele Mark P, Savov Jordan D, Hollingsworth John W, McElvania-Tekippe Erin, Berman Katherine G, Speer Marcy C, Sporn Thomas A., Brown Kevin K, Schwarz Marvin I., Schwartz David A.  Gene expression profiling of familial and sporadic interstitial pneumonia.  Am J Respir Crit Care Med.  175:45-54, 2007. (2007)

Martinu T, Howell DN, Davis RD, Steele MP, Palmer SM:  Pathological correlates of bronchiolitis obliterans syndrome in pulmonary retransplant recipients.  Chest.  129 (4): 1016-29, 2006.
(2006)

Steele MP, Speer MC, Loyd JC, Brown KK, Herron A, Slifer SH, Burch LH, Wahidi M, Phillips JA, Sporn TA, McAdams HP, Schwarz MI, Schwartz DA.  The role of genetics and cigarette smoking in the development of pulmonary fibrosis.  Respirology.  Jan 11; Supplement 1:S23, 2006. (2006)

Steele MP, Speer MC, Loyd  JE, Brown KK, Herron A, Slifer SH, Burch LH, Wahidi MM, Phillips JA, Sporn TA, McAdams HP, Schwarz MI, Schwartz DA.  Clinical and pathologic features of familial interstitial pneumonia.  Am J Respir Crit Care Med. Nov 1; 172(9):1146-1152, 2005. (2005)

Garantziotis S, Steele MP, Schwartz, DA. Pulmonary fibrosis: thinking outside the lung.  J Clin Invest. Aug 114(3):319-321, 2004. (2004)

Steele MP, Peterson MW, Schwartz DA:  Asbestosis and asbestos-induced pleural fibrosis.  In Interstitial Lung Disease, 4th edition.  M. Schwarz and T. King, Eds, B.C. Decker, Inc., 418-434, 2003.   (2003)

Clement, A., Steele, M.P., Brody, J.S., Reidel, N. Growth-related gene expression in alveolar type II epithelial cells. Am. Rev. Respir. Dis. 142S:60-62, 1990. (1990)