Division Chief, Endocrinology, Metabolism, and Nutrition
Departments / Divisions
Address
DUMC 3921
Durham, NC 27710
Appointment Telephone
919-668-7630
Office Telephone
919-684-4005
Fax Telephone
919-681-8477
Clinical Interests
Diabetes mellitus, with particular interest in patients with unstable diabetes,
insulin resistance, insulin allergy, poorly controlled type 2 diabetes,
hypothyroidism, hyperthyroidism
Research Interests
I am interested in the etiology and treatment of type 2 diabetes mellitus. For many years, we have studied the role of the autonomic nervous system in the pathophysiology of type 2 siabetes in humans and a murine model. We have also studied the mechanism of action of dietary therapy and a variety of pharmacological agents in the treatment of type 2 diabetes.
Dr. Richard Surwit of the Department of Psychiatry and Behavioral Sciences and I are conducting a variety of human studies on the relationship of stress hormones and various food additives on the development and expression of type 2 diabetes. I am also engaged in a number of multicenter studies of the effect of various treatment plans on cardiovascular outcome in type 2 diabetes patients. In addtion, my group continues to evaluate new treatment modalities for patients with type 2 diabetes, including new types of insulin, GLP-1 analogs, new classes of oral agents, and combinations of drugs.
I am frequently consulted by industry to evaluate new therapeutic modalities. I most frequently peer review scientific articles concerning the treatment of type 2 diabetes.
Key words: diabetes mellitus, stress, sulfonylureas, oral hypoglycemics, insulin, murine diabetes, diabetic diet
This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Representative Publications
Luna B., Feinglos, M.N.: Drug-induced Hyperglycemia. JAMA-J. Am. Med. Assoc. 286/16:1945-1948, 2001.
(2001)
Feinglos, M.N., Thacker, C.H., English, J.S., Bethel, M.A., Lane, J.D.: Modification of postprandial hyperglycemia with insulin lispro improves glucose control in patients with type 2 diabetes. Diabetes Care 20:1539-1542, 1997.
(1997)
Surwit, R.S., Seldin, M.F., Kuhn, C.M., Cochrane, C., and Feinglos, M.N.: Different genetic factors control the expression of insulin resistance and hypoglycemia in diabetic C57BL/6J mice. Diabetes 40:82-87, 1991.
(1991)
Feinglos, M.N., Hastedt, P., Surwit, R.S.: The effects of relaxation therapy on patients with type I diabetes mellitus. Diabetes Care 10:72-75, 1987.
(1987)
Feinglos, M.N. and Lebovitz, H.E.: Sulfonylureas increase the number of insulin receptors. Nature 276:184-185, 1978.
(1978)
