Division Chief, Endocrinology, Metabolism, and NutritionDepartments / Divisions
Durham, NC 27710
Diabetes mellitus, with particular interest in patients with unstable diabetes, insulin resistance, insulin allergy, poorly controlled type 2 diabetes, hypothyroidism, hyperthyroidism
I am interested in the etiology and treatment of type 2 diabetes mellitus. For many years, we have studied the role of the autonomic nervous system in the pathophysiology of type 2 diabetes in humans and a murine model. We have also studied the mechanism of action of dietary therapy and a variety of pharmacological agents in the treatment of type 2 diabetes.
Dr. Richard Surwit of the Department of Psychiatry and Behavioral Sciences and I are conducting a variety of human studies on the relationship of stress hormones and various food additives on the development and expression of type 2 diabetes. I am also engaged in a number of multicenter studies of the effect of various treatment plans on cardiovascular outcomes in type 2 diabetes patients. In addtion, my group continues to evaluate new treatment modalities for patients with type 2 diabetes, including new types of insulin, GLP-1 analogs, new classes of oral agents, and combinations of drugs.
I am frequently consulted by industry to evaluate new therapeutic modalities. I most frequently peer review scientific articles concerning the treatment of type 2 diabetes.
Key words: diabetes mellitus, stress, sulfonylureas, oral hypoglycemics, insulin, murine diabetes, diabetic diet
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.