Division Chief, HematologyDepartments / Divisions
Durham, NC 27710
Congenital and acquired erythrocyte membrane abnormalities, immune hemolytic anemia and thrombocytopenia, transfusion-related problems, sickle cell disease, general nonmalignant hematology
Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease. She is the Director of the Duke Comprehensive Sickle Cell Center.
Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells. Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors. The goals of this work are (1) to understand the mechanism and role of red cell adhesion to leukocytes and endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation (and inactivation) of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..
Recent investigations have focused on the role of signaling pathways in the upregulation of sickle red cell adhesion. Present studies include (1) investigation of beta-adrenergic signaling pathway responsible for activation of B-CAM/LU and LW adhesion receptors; (2) understanding how nitric oxide and ATP downregulate sickle red cell adhesion; (3) studying the effect of these processes in animal models.
Dr. Telen is also involved in a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertension in sickle cell disease.
Sickle cell disease
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Ballas, SK; Lieff, S; Benjamin, LJ; Dampier, CD; Heeney, MM; Hoppe, C; Johnson, CS; Rogers, ZR; Smith-Whitley, K; Wang, WC; Telen, MJ; Investigators, Comprehensive Sickle Cell Centers. Definitions of the phenotypic manifestations of sickle cell disease. American Journal of Hematology. 2010;85:6-13. (2010) Abstract
Brittain, JE; Hulkower, B; Jones, SK; Strayhorn, D; De Castro, L; Telen, MJ; Orringer, EP; Hinderliter, A; Ataga, KI. Placenta growth factor in sickle cell disease: association with hemolysis and inflammation. Blood. 2010;115:2014-2020. (2010) Abstract
Sangokoya, C; Telen, MJ; Chi, JT. microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease. Blood. 2010;116:4338-4348. (2010) Abstract
Sebastiani, P; Solovieff, N; Hartley, SW; Milton, JN; Riva, A; Dworkis, DA; Melista, E; Klings, ES; Garrett, ME; Telen, MJ; Ashley-Koch, A; Baldwin, CT; Steinberg, MH. Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study. American Journal of Hematology. 2010;85:29-35. (2010) Abstract
Solovieff, N; Milton, JN; Hartley, SW; Sherva, R; Sebastiani, P; Dworkis, DA; Klings, ES; Farrer, LA; Garrett, ME; Ashley-Koch, A; Telen, MJ; Fucharoen, S; Ha, SY; Li, CK; Chui, DH; Baldwin, CT; Steinberg, MH. Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster. Blood. 2010;115:1815-1822. (2010) Abstract
Afenyi-Annan, A; Kail, M; Combs, MR; Orringer, EP; Ashley-Koch, A; Telen, MJ. Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease. Transfusion. 2008;48:917-924. (2008) Abstract
Ashley-Koch, AE; Elliott, L; Kail, ME; De Castro, LM; Jonassaint, J; Jackson, TL; Price, J; Ataga, KI; Levesque, MC; Weinberg, JB; Orringer, EP; Collins, A; Vance, JM; Telen, MJ. Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. Blood. 2008;111:5721-5726. (2008) Abstract
De Castro, LM; Jonassaint, JC; Graham, FL; Ashley-Koch, A; Telen, MJ. Pulmonary hypertension associated with sickle cell disease: clinical and laboratory endpoints and disease outcomes. American Journal of Hematology. 2008;83:19-25. (2008) Abstract
Eyler, CE; Jackson, T; Elliott, LE; De Castro, LM; Jonassaint, J; Ashley-Koch, A; Telen, MJ. beta(2)-Adrenergic receptor and adenylate cyclase gene polymorphisms affect sickle red cell adhesion. British Journal of Haematology. 2008;141:105-108. (2008) Abstract
Zennadi, R; Chien, A; Xu, K; Batchvarova, M; Telen, MJ. Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium. Blood. 2008;112:3474-3483. (2008) Abstract
Zennadi, R; De Castro, L; Eyler, C; Xu, K; Ko, M; Telen, MJ. Role and regulation of sickle red cell interactions with other cells: ICAM-4 and other adhesion receptors. Transfusion Clinique et Biologique. 2008;15:23-28. (2008) Abstract
Bennett-Guerrero, E; Veldman, TH; Doctor, A; Telen, MJ; Ortel, TL; Reid, TS; Mulherin, MA; Zhu, H; Buck, RD; Califf, RM; McMahon, TJ. Evolution of adverse changes in stored RBCs. Proceedings of the National Academy of Sciences of USA. 2007;104:17063-17068. (2007) Abstract
Zennadi, R; Moeller, BJ; Whalen, EJ; Batchvarova, M; Xu, K; Shan, S; Delahunty, M; Dewhirst, MW; Telen, MJ. Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. Blood. 2007;110:2708-2717. (2007) Abstract
Zen, Q; Cottman, M; Truskey, G; Fraser, R; Telen, MJ. Critical factors in basal cell adhesion molecule/lutheran-mediated adhesion to laminin. Journal of Biological Chemistry. 1999;274:728-734. (1999) Abstract
Udani, M; Zen, Q; Cottman, M; Leonard, N; Jefferson, S; Daymont, C; Truskey, G; Telen, MJ. Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin. Journal of Clinical Investigation. 1998;101:2550-2558. (1998) Abstract