Division Chief, Hematology

Department / Division:
Medicine / Hematology

Address:
DUMC 2615
Durham, NC 27710

Appointment Telephone:
919-668-6688

Office Telephone:
919-684-5378

Fax Telephone:
919-681-7688

• MD, New York University School of Medicine, 1973-1977

• Medicine, State University of New York, Buffalo, 1979-1980
• Hematology/Immunohematology, Duke University Medical Center, 1980-1983

Clinical Interests:
Congenital and acquired erythrocyte membrane abnormalities, immune hemolytic anemia and thrombocytopenia, transfusion-related problems, sickle cell disease, general non-malignant hematology

Research Interests:
Dr. Telen is recognized as an expert in the biochemistry and molecular genetics of blood group antigens and the pathophysiological mechanisms of vaso-occlusion in sickle cell disease.  She is the Director of the Duke-UNC Comprehensive Sickle Cell Center.

Dr. Telen's laboratory focuses on structure/function analysis of membrane proteins expressed by erythroid cells, as well as the role of these proteins in non-erythroid cells.  Proteins are also studied in transfectant systems, and research focuses especially on adhesion receptors.  The goals of this work are (1) to understand the mechanism and role of red cell adhesion to endothelium in sickle cell disease; (2) to understand the signaling mechanisms leading to activation of red cell adhesion molecules; (3) to understand the molecular basis of blood group antigen expression, and (4) to understand the interactions of erythroid membrane proteins with other cells and with extracellular matrix..

Recent investigations have focused on the role of Lutheran blood group antigen protein as a laminin receptor and LW blood group antigen protein (ICAM-4) as an integrin receptor in sickle cell erythrocytes.  Present studies include (1) investigation of the roles of B-CAM/LU and LW in vaso-occlusion using in vivo models; (2) mapping of the functional domain of the B-CAM/LU laminin receptor, using recombinant proteins; (3) determination of the signaling mechanisms that activate the B-CAM/LU and LW receptors; (4) identification of additional ligands for B-CAM/LU; and (5)  interaction of CD44 and B-CAM/LU as adhesion molecules in cancer.

Dr. Telen is also currently the P.I. on a large multicenter study looking for genetic polymorphisms that affect clinical outcomes in sickle cell disease, as well as a multi-center study investigating the mechanisms and treatment of pulmonary hypertensin in sickle cell disease.


Key Words:

Adhesion molecules
Erythrocyte membrane
Sickle cell disease
Transfusion medicine
Immunohematology
CD44
B-CAM/LU
Genetic polymorphisms

Representative Publications:
De Castro LM, Jonassaint JC, Graham FL, Ashley-Koch A, Telen MJ. Pulmonary hypertension associated with sickle cell disease: Clinical and laboratory endpoints and disease outcomes. Am J Hematol. 2008 Jan;83(1):19-25. (2008) Abstract

Ashley-Koch AE, Elliott L, Kail ME, De Castro LM, Jonassaint J, Jackson TL, Price J, Ataga KI, Levesque MC, Weinberg JB, Orringer EP, Collins A, Vance JM, Telen MJ. Identification of genetic polymorphisms associated with risk for pulmonary hypertension in sickle cell disease. Blood. 2008 Jan 10. (2008) Abstract

Zennadi R, Moeller BJ, Whalen EJ, Batchvarova M, Xu K, Shan S, Delahunty M, Dewhirst MW, Telen MJ. Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. Blood. 2007 Oct 1;110(7):2708-17. (2007) Abstract

Telen MJ. Role of adhesion molecules and vascular endothelium in the pathogenesis of sickle cell disease. Hematology Am Soc Hematol Educ Program. 2007;2007:84-90. (2007) Abstract

Elliott L, Ashley-Koch AE, De Castro L, Jonassaint J, Price J, Ataga KI, Levesque MC, Brice Weinberg J, Eckman JR, Orringer EP, Vance JM, Telen MJ. Genetic polymorphisms associated with priapism in sickle cell disease. Br J Haematol. 2007 May;137(3):262-7. (2007) Abstract

Bennett-Guerrero E, Veldman TH, Doctor A, Telen MJ, Ortel TL, Reid TS, Mulherin MA, Zhu H, Buck RD, Califf RM, McMahon TJ. Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci U S A. 2007 Oct 23;104(43):17063-8. (2007) Abstract

Snell M, Chau C, Hendrix D, Fox R, Downes KA, Creger R, Meyerson H, Telen MJ, Laughlin MJ, Lazarus HM, Yomtovian R. Lack of isohemagglutinin production following minor ABO incompatible unrelated HLA mismatched umbilical cord blood transplantation. Bone Marrow Transplant. 2006 Jul;38(2):135-40. (2006) Abstract

Eyler CE, Telen MJ. The Lutheran glycoprotein: a multifunctional adhesion receptor. Transfusion. 2006 Apr;46(4):668-77. (2006) Abstract

Delahunty M, Zennadi R, Telen MJ. LW protein: a promiscuous integrin receptor activated by adrenergic signaling. Transfus Clin Biol. 2006 Mar-Apr;13(1-2):44-9. (2006) Abstract

Wanko SO, Telen MJ. Transfusion management in sickle cell disease. Hematol Oncol Clin North Am. 2005 Oct;19(5):803-26, v-vi. (2005) Abstract

Telen MJ. Erythrocyte adhesion receptors: blood group antigens and related molecules. Transfus Med Rev. 2005 Jan;19(1):32-44. (2005) Abstract

Murphy MM, Zayed MA, Evans A, Parker CE, Ataga KI, Telen MJ, Parise LV. Role of Rap1 in promoting sickle red blood cell adhesion to laminin via BCAM/LU. Blood. 2005 Apr 15;105(8):3322-9. (2005) Abstract

Itakura H, Telen MJ, Hoppe CC, White DA, Zehnder JL. Characterization of a novel prothrombin variant, Prothrombin C20209T, as a modifier of thrombotic risk among African-Americans. J Thromb Haemost. 2005 Oct;3(10):2357-9. (2005) Abstract

Zennadi R, Hines PC, De Castro LM, Cartron JP, Parise LV, Telen MJ. Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW-alphavbeta3 interactions. Blood. 2004 Dec 1;104(12):3774-81. (2004) Abstract

Zen Q, Batchvarova M, Twyman CA, Eyler CE, Qiu H, De Castro LM, Telen MJ. B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. Am J Hematol. 2004 Feb;75(2):63-72. (2004) Abstract

Drewniok C, Wienrich BG, Schön M, Ulrich J, Zen Q, Telen MJ, Hartig RJ, Wieland I, Gollnick H, Schön MP. Molecular interactions of B-CAM (basal-cell adhesion molecule) and laminin in epithelial skin cancer. Arch Dermatol Res. 2004 Jul;296(2):59-66. (2004) Abstract

Hines PC, Zen Q, Burney SN, Shea DA, Ataga KI, Orringer EP, Telen MJ, Parise LV. Novel epinephrine and cyclic AMP-mediated activation of BCAM/Lu-dependent sickle (SS) RBC adhesion. Blood. 2003 Apr 15;101(8):3281-7. (2003) Abstract

Zen Q, Cottman M, Truskey G, Fraser R, Telen MJ. Critical factors in basal cell adhesion molecule/lutheran-mediated adhesion to laminin. J Biol Chem. 1999 Jan 8;274(2):728-34. (1999) Abstract

Udani M, Zen Q, Cottman M, Leonard N, Jefferson S, Daymont C, Truskey G, Telen MJ. Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin. J Clin Invest. 1998 Jun 1;101(11):2550-8. (1998) Abstract

Telen, M.J., Udani, M., Washington, M.K., Levesque, M.D., Lloyd, E., Rao, N.: A blood group related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. J. Biol. Chem., 271(12):7147-53, 1996. (1996)