M. Anthony Moody, MD

Department / Division:
Pediatrics / Infectious Diseases

Address:
DUMC 3499
Durham, NC 27710

Appointment Telephone:
919-668-4000

Office Telephone:
919-684-6335

• MD, Duke University School of Medicine, 1999

• Categorical Pediatrics, Emory University School of Medicine (Georgia), 1999-2002
• Pediatrics, Chief Resident, Emory University School of Medicine (Georgia), 2002-2003

• Pediatric Infectious Diseases, Duke University School of Medicine, 2003-2006

Clinical Interests:
General pediatric infectious diseases, pediatric tuberculosis, sexually transmitted infections

Research Interests:
My current research is in four related areas.

1) My laboratory is developing tools for the analysis of antigen-specific B cells ranging from whole protein probes down to the single epitope level so that we interrogate the response to various pathogens and immunization strategies including the response to HIV-1 and influenza.  In addition we are collaborating with number of groups to develop tools to identify and characterize B cells in a variety of other conditions including autoimmune diseases and the response to routine vaccination.

2) My laboratory performs flow cytometry on the B cell arm of the immune system for DHVI and CHAVI.  We develop new panels and analysis protocols to characterize human B cells that are obtained from various human and non-human primate protocols.  The purpose of this work is to determine the alterations in B cells during acute and chronic HIV infection, in other infection models, in autoimmune disease, and in animal vaccine models.

3) I am Chief Medical Officer of DHVI and I supervise a number of clinical protocols for the Center for HIV/AIDS Vaccine Immunology (CHAVI) aimed at recruiting autoimmune patients, patients who are infected or might have been exposed to HIV-1, and healthy controls to investigate the role of autoimmune diseases and other factors in the ability to make broadly reactive antibodies against HIV-1 or to control HIV-1 infection.

4) I am interested in the activity of novel inhibitors of HIV-1 infection to determine their mechanisms of action at a cellular and molecular level and the potential translation of those inhibitors into clinically useful interventions for the prevention of HIV-1 infection.

Representative Publications:
Liao HX, Levesque MC, Nagel A, Dixon A, Zhang R, Walter E, Parks R, Whitesides J, Marshall DJ, Hwang KK, Yang Y, Chen X, Gao F, Munshaw S, Kepler TB, Denny T, Moody MA, Haynes BF. High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. J Virol Methods. 2009 Jun;158(1-2):171-9. (2009) Abstract

Levesque MC, Moody MA, Hwang KK, Marshall DJ, Whitesides JF, Amos JD, Gurley TC, Allgood S, Haynes BB, Vandergrift NA, Plonk S, Parker DC, Cohen MS, Tomaras GD, Goepfert PA, Shaw GM, Schmitz JE, Eron JJ, Shaheen NJ, Hicks CB, Liao HX, Markowitz M, Kelsoe G, Margolis DM, Haynes BF. Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. PLoS Med. 2009 Jul 7;6(7):e1000107. (2009) Abstract

Bonsignori M, Moody MA, Parks RJ, Holl TM, Kelsoe G, Hicks CB, Vandergrift N, Tomaras GD, Haynes BF. HIV-1 Envelope Induces Memory B Cell Responses That Correlate with Plasma Antibody Levels after Envelope gp120 Protein Vaccination or HIV-1 Infection. J Immunol. 2009 Jul 22. (2009) Abstract

Roederer M, Moody MA. Polychromatic plots: graphical display of multidimensional data. Cytometry A. 2008 Sep;73(9):868-74. (2008) Abstract

Moody MA, Haynes BF. Antigen-specific B cell detection reagents: use and quality control. Cytometry A. 2008 Nov;73(11):1086-92. (2008) Abstract

Greenberg RG, Smith PB, Cotten CM, Moody MA, Clark RH, Benjamin DK Jr. Traumatic lumbar punctures in neonates: test performance of the cerebrospinal fluid white blood cell count. Pediatr Infect Dis J. 2008 Dec;27(12):1047-51. (2008) Abstract

Gasper-Smith N, Crossman DM, Whitesides JF, Mensali N, Ottinger JS, Plonk SG, Moody MA, Ferrari G, Weinhold KJ, Miller SE, Reich CF 3rd, Qin L, Self SG, Shaw GM, Denny TN, Jones LE, Pisetsky DS, Haynes BF. Induction of plasma (TRAIL), TNFR-2, Fas ligand, and plasma microparticles after human immunodeficiency virus type 1 (HIV-1) transmission: implications for HIV-1 vaccine design. J Virol. 2008 Aug;82(15):7700-10. (2008) Abstract

Alam SM, Scearce RM, Parks RJ, Plonk K, Plonk SG, Sutherland LL, Gorny MK, Zolla-Pazner S, Vanleeuwen S, Moody MA, Xia SM, Montefiori DC, Tomaras GD, Weinhold KJ, Karim SA, Hicks CB, Liao HX, Robinson J, Shaw GM, Haynes BF. Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection. J Virol. 2008 Jan;82(1):115-25. (2008) Abstract

Garges HP, Moody MA, Cotten CM, Smith PB, Tiffany KF, Lenfestey R, Li JS, Fowler VG Jr, Benjamin DK Jr. Neonatal meningitis: what is the correlation among cerebrospinal fluid cultures, blood cultures, and cerebrospinal fluid parameters? Pediatrics. 2006 Apr;117(4):1094-100. (2006) Abstract

Haynes BF, Moody MA, Verkoczy L, Kelsoe G, Alam SM. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Hum Antibodies. 2005;14(3-4):59-67. (2005) Abstract

Haynes BF, Moody MA, Heinley CS, Korber B, Millard WA, Scearce RM. HIV type 1 V3 region primer-induced antibody suppression is overcome by administration of C4-V3 peptides as a polyvalent immunogen. AIDS Res Hum Retroviruses. 1995 Feb;11(2):211-21. (1995) Abstract