Physicians

Department / Division
Pediatrics / Pediatrics-Infectious Diseases

Address
DUMC 3499
Durham, NC 27710

Appointment Telephone
919-668-4000

Office Telephone
919-684-6335

Training

• MD, Duke University School of Medicine, 1999

Residency

• Categorical Pediatrics, Emory University School of Medicine (Georgia), 1999-2002
• Pediatrics, Chief Resident, Emory University School of Medicine (Georgia), 2002-2003

Fellowship

• Pediatric Infectious Diseases, Duke University School of Medicine, 2003-2006

Clinical Interests
General pediatric infectious diseases, pediatric tuberculosis, sexually transmitted infections

Research Interests
Tony Moody, MD is an Assistant Professor in the Department of Pediatrics, Division of Infectious Diseases at Duke University Medical Center. Dr. Moody is the Director of the Laboratory of B cell Immunotechnology at the Duke Human Vaccine Institute (DHVI). Research in the Moody lab is focused on understanding the B cell responses during the earliest stages of HIV infection. The lab has become a resource for human phenotyping, flow characterization, staining and analysis at DHVI. Additionally, Dr. Moody serves as the Chief Medical Officer for DHVI and as the Director of the CHAVI DHVI Repository.

Human B cell Immunology

The Moody lab is studying changes to the B cell arm of the immune system during the earliest time points after HIV infection, as early as 17 days after transmission. This group recently elucidated the alterations to B cells that occur during acute/early HIV infection and have submitted a manuscript describing this work. The Moody lab is one of several working on the Antibodyome project--a project that seeks to understand the repertoire of antibodies produced in response to vaccination and infection. The lab continues to work on the development of new flow cytometric panels and reagents that can enhance the detection of B cell responses during the acute/early HIV infection.

In addition, the Moody lab has active projects looking at the response to influenza and dengue, and is interested in applying the technique to other disease processes.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Schmidt, AG; Xu, H; Khan, AR; O'Donnell, T; Khurana, S; King, LR; Manischewitz, J; Golding, H; Suphaphiphat, P; Carfi, A; Settembre, EC; Dormitzer, PR; Kepler, TB; Zhang, R; Moody, MA; Haynes, BF; Liao, HX; Shaw, DE; Harrison, SC. Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody. Proceedings of the National Academy of Sciences of USA. 2013;110:264-269. (2013) Abstract

Bonsignori, M; Alam, SM; Liao, HX; Verkoczy, L; Tomaras, GD; Haynes, BF; Moody, MA. HIV-1 antibodies from infection and vaccination: insights for guiding vaccine design. Trends in Microbiology. 2012;20:532-539. (2012) Abstract

Bonsignori, M; Pollara, J; Moody, MA; Alpert, MD; Chen, X; Hwang, KK; Gilbert, PB; Huang, Y; Gurley, TC; Kozink, DM; Marshall, DJ; Whitesides, JF; Tsao, CY; Kaewkungwal, J; Nitayaphan, S; Pitisuttithum, P; Rerks-Ngarm, S; Kim, JH; Michael, NL; Tomaras, GD; Montefiori, DC; Lewis, GK; DeVico, A; Evans, DT; Ferrari, G; Liao, HX; Haynes, BF. Antibody-dependent cellular cytotoxicity-mediating antibodies from an HIV-1 vaccine efficacy trial target multiple epitopes and preferentially use the VH1 gene family. Journal of Virology. 2012;86:11521-11532. (2012) Abstract

Friedman, J; Alam, SM; Shen, X; Xia, SM; Stewart, S; Anasti, K; Pollara, J; Fouda, GG; Yang, G; Kelsoe, G; Ferrari, G; Tomaras, GD; Haynes, BF; Liao, HX; Moody, MA; Permar, SR. Isolation of HIV-1-neutralizing mucosal monoclonal antibodies from human colostrum. PLoS One. 2012;7:e37648. (2012) Abstract

Montefiori, DC; Karnasuta, C; Huang, Y; Ahmed, H; Gilbert, P; de Souza, MS; McLinden, R; Tovanabutra, S; Laurence-Chenine, A; Sanders-Buell, E; Moody, MA; Bonsignori, M; Ochsenbauer, C; Kappes, J; Tang, H; Greene, K; Gao, H; LaBranche, CC; Andrews, C; Polonis, VR; Rerks-Ngarm, S; Pitisuttithum, P; Nitayaphan, S; Kaewkungwal, J; Self, SG; Berman, PW; Francis, D; Sinangil, F; Lee, C; Tartaglia, J; Robb, ML; Haynes, BF; Michael, NL; Kim, JH. Magnitude and breadth of the neutralizing antibody response in the RV144 and Vax003 HIV-1 vaccine efficacy trials. Journal of Infectious Diseases. 2012;206:431-441. (2012) Abstract

Moody, MA; Yates, NL; Amos, JD; Drinker, MS; Eudailey, JA; Gurley, TC; Marshall, DJ; Whitesides, JF; Chen, X; Foulger, A; Yu, JS; Zhang, R; Meyerhoff, RR; Parks, R; Scull, JC; Wang, L; Vandergrift, NA; Pickeral, J; Pollara, J; Kelsoe, G; Alam, SM; Ferrari, G; Montefiori, DC; Voss, G; Liao, HX; Tomaras, GD; Haynes, BF. HIV-1 gp120 vaccine induces affinity maturation in both new and persistent antibody clonal lineages. Journal of Virology. 2012;86:7496-7507. (2012) Abstract

Song, H; Pavlicek, JW; Cai, F; Bhattacharya, T; Li, H; Iyer, SS; Bar, KJ; Decker, JM; Goonetilleke, N; Liu, MK; Berg, A; Hora, B; Drinker, MS; Eudailey, J; Pickeral, J; Moody, MA; Ferrari, G; McMichael, A; Perelson, AS; Shaw, GM; Hahn, BH; Haynes, BF; Gao, F. Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome. Retrovirology. 2012;9:89. (2012) Abstract

Thomas, R; Thio, CL; Apps, R; Qi, Y; Gao, X; Marti, D; Stein, JL; Soderberg, KA; Moody, MA; Goedert, JJ; Kirk, GD; Hoots, WK; Wolinsky, S; Carrington, M. A novel variant marking HLA-DP expression levels predicts recovery from hepatitis B virus infection. Journal of Virology. 2012;86:6979-6985. (2012) Abstract

Bonsignori, M; Hwang, KK; Chen, X; Tsao, CY; Morris, L; Gray, E; Marshall, DJ; Crump, JA; Kapiga, SH; Sam, NE; Sinangil, F; Pancera, M; Yongping, Y; Zhang, B; Zhu, J; Kwong, PD; O'Dell, S; Mascola, JR; Wu, L; Nabel, GJ; Phogat, S; Seaman, MS; Whitesides, JF; Moody, MA; Kelsoe, G; Yang, X; Sodroski, J; Shaw, GM; Montefiori, DC; Kepler, TB; Tomaras, GD; Alam, SM; Liao, HX; Haynes, BF. Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors. Journal of Virology. 2011;85:9998-10009. (2011) Abstract

Ferrari, G; Pollara, J; Kozink, D; Harms, T; Drinker, M; Freel, S; Moody, MA; Alam, SM; Tomaras, GD; Ochsenbauer, C; Kappes, JC; Shaw, GM; Hoxie, JA; Robinson, JE; Haynes, BF. An HIV-1 gp120 envelope human monoclonal antibody that recognizes a C1 conformational epitope mediates potent antibody-dependent cellular cytotoxicity (ADCC) activity and defines a common ADCC epitope in human HIV-1 serum. Journal of Virology. 2011;85:7029-7036. (2011) Abstract

Gray, ES; Moody, MA; Wibmer, CK; Chen, X; Marshall, D; Amos, J; Moore, PL; Foulger, A; Yu, JS; Lambson, B; Abdool Karim, S; Whitesides, J; Tomaras, GD; Haynes, BF; Morris, L; Liao, HX. Isolation of a monoclonal antibody that targets the alpha-2 helix of gp120 and represents the initial autologous neutralizing-antibody response in an HIV-1 subtype C-infected individual. Journal of Virology. 2011;85:7719-7729. (2011) Abstract

Haynes, BF; Moody, MA; Liao, HX; Verkoczy, L; Tomaras, GD. B cell responses to HIV-1 infection and vaccination: pathways to preventing infection. Trends in Molecular Medicine. 2011;17:108-116. (2011) Abstract

Jiang, C; Parrish, NF; Wilen, CB; Li, H; Chen, Y; Pavlicek, JW; Berg, A; Lu, X; Song, H; Tilton, JC; Pfaff, JM; Henning, EA; Decker, JM; Moody, MA; Drinker, MS; Schutte, R; Freel, S; Tomaras, GD; Nedellec, R; Mosier, DE; Haynes, BF; Shaw, GM; Hahn, BH; Doms, RW; Gao, F. Primary infection by a human immunodeficiency virus with atypical coreceptor tropism. Journal of Virology. 2011;85:10669-10681. (2011) Abstract

Liao, HX; Chen, X; Munshaw, S; Zhang, R; Marshall, DJ; Vandergrift, N; Whitesides, JF; Lu, X; Yu, JS; Hwang, KK; Gao, F; Markowitz, M; Heath, SL; Bar, KJ; Goepfert, PA; Montefiori, DC; Shaw, GC; Alam, SM; Margolis, DM; Denny, TN; Boyd, SD; Marshal, E; Egholm, M; Simen, BB; Hanczaruk, B; Fire, AZ; Voss, G; Kelsoe, G; Tomaras, GD; Moody, MA; Kepler, TB; Haynes, BF. Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated. Journal of Experimental Medicine. 2011;208:2237-2249. (2011) Abstract

Moody, MA; Zhang, R; Walter, EB; Woods, CW; Ginsburg, GS; McClain, MT; Denny, TN; Chen, X; Munshaw, S; Marshall, DJ; Whitesides, JF; Drinker, MS; Amos, JD; Gurley, TC; Eudailey, JA; Foulger, A; DeRosa, KR; Parks, R; Meyerhoff, RR; Yu, JS; Kozink, DM; Barefoot, BE; Ramsburg, EA; Khurana, S; Golding, H; Vandergrift, NA; Alam, SM; Tomaras, GD; Kepler, TB; Kelsoe, G; Liao, HX; Haynes, BF. H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination. PLoS One. 2011;6:e25797. (2011) Abstract

Morris, L; Chen, X; Alam, M; Tomaras, G; Zhang, R; Marshall, DJ; Chen, B; Parks, R; Foulger, A; Jaeger, F; Donathan, M; Bilska, M; Gray, ES; Abdool Karim, SS; Kepler, TB; Whitesides, J; Montefiori, D; Moody, MA; Liao, HX; Haynes, BF. Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting. PLoS One. 2011;6:e23532. (2011) Abstract

Verkoczy, L; Kelsoe, G; Moody, MA; Haynes, BF. Role of immune mechanisms in induction of HIV-1 broadly neutralizing antibodies. Current Opinion in Immunology. 2011;23:383-390. (2011) Abstract

Warner, DA; Moody, MA; Telemeco, RS. Is water uptake by reptilian eggs regulated by physiological processes of embryos or a passive hydraulic response to developmental environments?. Comparative Biochemistry and Physiology Part A: Molecular and Integrative Physiology. 2011;160:421-425. (2011) Abstract

Whittle, JR; Zhang, R; Khurana, S; King, LR; Manischewitz, J; Golding, H; Dormitzer, PR; Haynes, BF; Walter, EB; Moody, MA; Kepler, TB; Liao, HX; Harrison, SC. Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin. Proceedings of the National Academy of Sciences of USA. 2011;108:14216-14221. (2011) Abstract

Zhu, Z; Qin, HR; Chen, W; Zhao, Q; Shen, X; Schutte, R; Wang, Y; Ofek, G; Streaker, E; Prabakaran, P; Fouda, GG; Liao, HX; Owens, J; Louder, M; Yang, Y; Klaric, KA; Moody, MA; Mascola, JR; Scott, JK; Kwong, PD; Montefiori, D; Haynes, BF; Tomaras, GD; Dimitrov, DS. Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies. Journal of Virology. 2011;85:11401-11408. (2011) Abstract

Alter, G; Moody, MA. The humoral response to HIV-1: new insights, renewed focus. Journal of Infectious Diseases. 2010;202 Suppl 2:S315-S322. (2010) Abstract

Moody, MA; Liao, HX; Alam, SM; Scearce, RM; Plonk, MK; Kozink, DM; Drinker, MS; Zhang, R; Xia, SM; Sutherland, LL; Tomaras, GD; Giles, IP; Kappes, JC; Ochsenbauer-Jambor, C; Edmonds, TG; Soares, M; Barbero, G; Forthal, DN; Landucci, G; Chang, C; King, SW; Kavlie, A; Denny, TN; Hwang, KK; Chen, PP; Thorpe, PE; Montefiori, DC; Haynes, BF. Anti-phospholipid human monoclonal antibodies inhibit CCR5-tropic HIV-1 and induce beta-chemokines. Journal of Experimental Medicine. 2010;207:763-776. (2010) Abstract

Robinson, AB; DeWitt, EM; Schanberg, LE; Moody, MA. Necrotizing fasciitis caused by Haemophilus influenzae type E in a 17-year-old girl with systemic lupus erythematosus. Journal of Clinical Rheumatology: practical reports on rheumatic and musculoskeletal disease. 2010;16:49-50. (2010) Abstract

Levesque, MC; Moody, MA; Hwang, KK; Marshall, DJ; Whitesides, JF; Amos, JD; Gurley, TC; Allgood, S; Haynes, BB; Vandergrift, NA; Plonk, S; Parker, DC; Cohen, MS; Tomaras, GD; Goepfert, PA; Shaw, GM; Schmitz, JE; Eron, JJ; Shaheen, NJ; Hicks, CB; Liao, HX; Markowitz, M; Kelsoe, G; Margolis, DM; Haynes, BF. Polyclonal B cell differentiation and loss of gastrointestinal tract germinal centers in the earliest stages of HIV-1 infection. PLoS Medicine. 2009;6:e1000107. (2009) Abstract

Liao, HX; Levesque, MC; Nagel, A; Dixon, A; Zhang, R; Walter, E; Parks, R; Whitesides, J; Marshall, DJ; Hwang, KK; Yang, Y; Chen, X; Gao, F; Munshaw, S; Kepler, TB; Denny, T; Moody, MA; Haynes, BF. High-throughput isolation of immunoglobulin genes from single human B cells and expression as monoclonal antibodies. Journal of Virological Methods. 2009;158:171-179. (2009) Abstract

Moody, MA; Haynes, BF. Antigen-specific B cell detection reagents: use and quality control. Cytometry Part A. 2008;73:1086-1092. (2008) Abstract

Roederer, M; Moody, MA. Polychromatic plots: graphical display of multidimensional data. Cytometry Part A. 2008;73:868-874. (2008) Abstract

Haynes, BF; Moody, MA; Verkoczy, L; Kelsoe, G; Alam, SM. Antibody polyspecificity and neutralization of HIV-1: a hypothesis. Human Antibodies. 2005;14:59-67. (2005) Abstract