Physicians

Department / Division
Medicine / Medicine-Infectious Diseases

Address
DUMC 102359
Durham, NC 27710

Appointment Telephone
919-684-4596

Office Telephone
919-684-4596

Fax Telephone
919-681-7494

Training

• MBBS (Hons), University of Melbourne (Australia), 1999

Residency

• Internal Medicine, Saint Vincent's Hospital (Australia), 2000-2004

Fellowship

• Infectious Diseases, The Alfred Hospital (Australia), 2004
• Infectious Diseases, Monash Medical Center (Australia), 2005
• Infectious Diseases (National Centre in HIV Epidemiology and Clinical Research), The Alfred Hospital (Australia), 2006
• Infectious Diseases, Duke University Medical Center, 2007-2009

Other Training

• Fellow, Royal Australasian College of Physicians (Australia), 2006
• Postgraduate Certificate in Clinical Trials, Monash University (Australia), 2007
• Certified in Infection Control, 2009
• MPH, Epidemiology, Johns Hopkins University Bloomberg School of Public Health (Maryland), 2010

Clinical Interests
Multidrug resistant organisms, drug-resistant gram-negative pathogens, health care epidemiology, HIV medicine, infection control and prevention, health care-associated infections, including bloodstream and surgical-site infections

Research Interests
Multi-drug resistant organisms, drug-resistant gram-negative pathogens (e.g. ESBL, KPC, NDM-1), health care epidemiology, HIV medicine, respiratory viral infections, infection control and prevention, health care-associated infections including bloodstream and surgical-site infections

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Cubist Pharmaceuticals, Inc.
• Medscape ( WebMD HLTH Corp.)
• Merck & Co. USA (not assoc'd with Merck KGaA)
• Optimer Pharmaceuticals

Representative Publications
Chen, LF. The changing epidemiology of methicillin-resistant Staphylococcus aureus: 50 years of a superbug. American Journal of Infection Control. 2013;41:448-451. (2013) Abstract

Chen, LF; Carriker, C; Staheli, R; Isaacs, P; Elliott, B; Miller, BA; Anderson, DJ; Moehring, RW; Vereen, S; Bringhurst, J; Rhodes, L; Strittholt, N; Sexton, DJ. Observing and improving hand hygiene compliance: implementation and refinement of an electronic-assisted direct-observer hand hygiene audit program. Infection Control and Hospital Epidemiology. 2013;34:207-210. (2013) Abstract

Lewis, SS; Moehring, RW; Anderson, DJ; Sexton, DJ; Chen, LF. Increasing rates of methicillin-resistant Staphylococcus aureus in academic hospitals: a result of active surveillance?. Infection Control and Hospital Epidemiology. 2013;34:105-106. (2013) Abstract

Moehring, RW; Staheli, R; Miller, BA; Chen, LF; Sexton, DJ; Anderson, DJ. Central line-associated infections as defined by the Centers for Medicare and Medicaid Services' Hospital-acquired condition versus standard infection control surveillance: why hospital compare seems conflicted. Infection Control and Hospital Epidemiology. 2013;34:238-244. (2013) Abstract

Chen, LF; Anderson, DJ. Efficacy and safety of fidaxomicin compared with oral vancomycin for the treatment of adults with Clostridium difficile-associated diarrhea: data from the OPT-80-003 and OPT-80-004 studies. Future Microbiology. 2012;7:677-683. (2012) Abstract

Chen, LF; Anderson, DJ; Paterson, DL. Overview of the epidemiology and the threat of Klebsiella pneumoniae carbapenemases (KPC) resistance. Infection and Drug Resistance. 2012;5:133-141. (2012) Abstract

Chen, LF; Arduino, JM; Sheng, S; Muhlbaier, LH; Kanafani, ZA; Harris, AD; Fraser, TG; Allen, K; Corey, GR; Fowler, VG. Epidemiology and outcome of major postoperative infections following cardiac surgery: risk factors and impact of pathogen type. American Journal of Infection Control. 2012;40:963-968. (2012) Abstract

Davis, ME; Anderson, DJ; Sharpe, M; Chen, LF; Drew, RH. Constructing unit-specific empiric treatment guidelines for catheter-related and primary bacteremia by determining the likelihood of inadequate therapy. Infection Control and Hospital Epidemiology. 2012;33:416-420. (2012) Abstract

Dicks, KV; Staheli, R; Anderson, DJ; Miller, BA; Jones, WS; Harrison, JK; Sexton, DJ; Moehring, RW; Chen, LF. "What the eyes don't see, the heart doesn't grieve over": epidemiology and risk factors for bloodstream infections following cardiac catheterization. Infection Control and Hospital Epidemiology. 2012;33:837-841. (2012) Abstract

Ming, DY; Chen, LF; Miller, BA; Anderson, DJ. The impact of depth of infection and postdischarge surveillance on rate of surgical-site infections in a network of community hospitals. Infection Control and Hospital Epidemiology. 2012;33:276-282. (2012) Abstract

Sexton, DJ; Chen, LF; Moehring, R; Thacker, PA; Anderson, DJ. Casablanca redux: we are shocked that public reporting of rates of central line-associated bloodstream infections are inaccurate. Infection Control and Hospital Epidemiology. 2012;33:932-935. (2012) Abstract

Tong, SY; Chen, LF; Fowler, VG. Colonization, pathogenicity, host susceptibility, and therapeutics for Staphylococcus aureus: what is the clinical relevance?. Springer Seminars in Immunopathology. 2012;34:185-200. (2012) Abstract

Anderson, DJ; Miller, BA; Chen, LF; Adcock, LH; Cook, E; Cromer, AL; Louis, S; Thacker, PA; Sexton, DJ. The network approach for prevention of healthcare-associated infections: long-term effect of participation in the Duke Infection Control Outreach Network. Infection Control and Hospital Epidemiology. 2011;32:315-322. (2011) Abstract

Chen, LF; Chastain, C; Anderson, DJ. Community-Acquired Methicillin-Resistant Staphylococcus aureus Skin and Soft Tissue Infections: Management and Prevention. Current Infectious Disease Reports. 2011;13:442-450. (2011) Abstract

Chen, LF; Chopra, T; Kaye, KS. Pathogens resistant to antibacterial agents. Medical Clinics of North America. 2011;95:647-vii. (2011) Abstract

Chen, LF; Dailey, NJ; Rao, AK; Fleischauer, AT; Greenwald, I; Deyde, VM; Moore, ZS; Anderson, DJ; Duffy, J; Gubareva, LV; Sexton, DJ; Fry, AM; Srinivasan, A; Wolfe, CR. Cluster of oseltamivir-resistant 2009 pandemic influenza A (H1N1) virus infections on a hospital ward among immunocompromised patients--North Carolina, 2009. Journal of Infectious Diseases. 2011;203:838-846. (2011) Abstract

Chen, LF; Kaye, D. Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides. Medical Clinics of North America. 2011;95:819-ix. (2011) Abstract

DiMondi, VP; Drew, RH; Chen, LF. Ceftaroline fosamil for treatment of community-acquired pneumonia: findings from FOCUS 1 and 2 and potential role in therapy. Expert Review of Anti-infective Therapy. 2011;9:567-572. (2011) Abstract

Freeman, JT; Chen, LF; Sexton, DJ; Anderson, DJ. Blood culture contamination with Enterococci and skin organisms: implications for surveillance definitions of primary bloodstream infections. American Journal of Infection Control. 2011;39:436-438. (2011) Abstract

Miller, BA; Chen, LF; Sexton, DJ; Anderson, DJ. Comparison of the burdens of hospital-onset, healthcare facility-associated Clostridium difficile Infection and of healthcare-associated infection due to methicillin-resistant Staphylococcus aureus in community hospitals. Infection Control and Hospital Epidemiology. 2011;32:387-390. (2011) Abstract

Chen, LF; Anderson, DJ; Kaye, KS; Sexton, DJ. Validating a 3-point prediction rule for surgical site infection after coronary artery bypass surgery. Infection Control and Hospital Epidemiology. 2010;31:64-68. (2010) Abstract

Sexton, DJ; Chen, LF; Anderson, DJ. Current definitions of central line-associated bloodstream infection: is the emperor wearing clothes?. Infection Control and Hospital Epidemiology. 2010;31:1286-1289. (2010) Abstract

Anderson, DJ; Kaye, KS; Chen, LF; Schmader, KE; Choi, Y; Sloane, R; Sexton, DJ. Clinical and financial outcomes due to methicillin resistant Staphylococcus aureus surgical site infection: a multi-center matched outcomes study. PLoS One. 2009;4:e8305. (2009) Abstract

Chen, LF; Chopra, T; Kaye, KS. Pathogens resistant to antibacterial agents. Infectious Disease Clinics of North America. 2009;23:817-vii. (2009) Abstract

Chen, LF; Kaye, D. Current use for old antibacterial agents: polymyxins, rifamycins, and aminoglycosides. Infectious Disease Clinics of North America. 2009;23:1053-x. (2009) Abstract

Chen, LF; Sexton, DJ; Kaye, KS; Anderson, DJ. Patient-days: a better measure of incidence of occupational bloodborne exposures. American Journal of Infection Control. 2009;37:534-540. (2009) Abstract

Herzke, CA; Chen, LF; Anderson, DJ; Choi, Y; Sexton, DJ; Kaye, KS. Empirical antimicrobial therapy for bloodstream infection due to methicillin-resistant Staphylococcus aureus: no better than a coin toss. Infection Control and Hospital Epidemiology. 2009;30:1057-1061. (2009) Abstract

Kaye, KS; Anderson, DJ; Sloane, R; Chen, LF; Choi, Y; Link, K; Sexton, DJ; Schmader, KE. The effect of surgical site infection on older operative patients. Journal of the American Geriatrics Society. 2009;57:46-54. (2009) Abstract

Trinh, JV; Chen, LF; Sexton, DJ; Anderson, DJ. Risk factors for gram-negative bacterial surgical site infection: do allergies to antibiotics increase risk?. Infection Control and Hospital Epidemiology. 2009;30:440-446. (2009) Abstract

Anderson, DJ; Chen, LF; Schmader, KE; Sexton, DJ; Choi, Y; Link, K; Sloane, R; Kaye, KS. Poor functional status as a risk factor for surgical site infection due to methicillin-resistant Staphylococcus aureus. Infection Control and Hospital Epidemiology. 2008;29:832-839. (2008) Abstract

Anderson, DJ; Richet, H; Chen, LF; Spelman, DW; Hung, YJ; Huang, AT; Sexton, DJ; Raoult, D. Seasonal variation in Klebsiella pneumoniae bloodstream infection on 4 continents. Journal of Infectious Diseases. 2008;197:752-756. (2008) Abstract

Chen, LF; Anderson, DJ; Hartwig, MG; Kaye, KS; Sexton, DJ. Surgical site infections after laparoscopic and open cholecystectomies in community hospitals . Infection Control and Hospital Epidemiology. 2008;29:92-94. (2008) Abstract

Chen, LF; Anderson, DJ; Kaye, KS; Sexton, DJ. Methicillin-resistant Staphylococcus aureus in hospitals: time for a culture change. Medical Journal of Australia. 2008;188:62-63. (2008) Abstract

Chen, LF; Sexton, DJ. What's new in Rocky Mountain spotted fever?. Infectious Disease Clinics of North America. 2008;22:415-viii. (2008) Abstract

Chen, LF; Hoy, J; Lewin, SR. Ten years of highly active antiretroviral therapy for HIV infection. Medical Journal of Australia. 2007;186:146-151. (2007) Abstract

Chen, LF; Woolley, IJ; Visvanathan, K; Korman, TM. Hypovolemic shock and metabolic acidosis in a refugee secondary to O1 serotype Vibrio cholerae enteritis. Communicable Diseases Intelligence Quarterly Report. 2006;30:233-235. (2006) Abstract