Leslie G. Dodd, MD
Department / Division
Pathology /
Pathology Clinical Services
Address
DUMC 3712
Durham, NC 27710
Office Telephone
919-684-4093
Fax Telephone
919-684-1856
- MD, University of Nevada School of Medicine, 1987
- Pathology, UCLA Medical Center (California), 1987-1991
- Surgical Pathology and Cytopathology, MD Anderson Cancer Center (Texas),
- 1991-1992
Clinical Interests
Surgical pathology and cytopathology, fine-needle aspiration, bone and soft-tissue neoplasms
Research Interests
Surgical Pathology and cytopathology of neoplasms.
Orthopedic pathology
Current research interests include: 1. Characterization of solid organ neoplasms by fine needle aspiration (FNA) cytology and 2. Quantification of tumor characteristics using digital cell image analysis. In cytology, current interests center around the characterization of neoplastic diseases: refining the criteria for FNA diagnosis of tumors, expanding the use of FNA in primary diagnosis, and findings of unusual lesions. A related interest is the correlation between cytopathology and histopathologic findings of neoplasms. Ongoing studies in the cell imaging lab concern the concept of tumor heterogeneity. Intratumoral heterogeneity, defined as the existence of more than one stemline of malignant cells per primary tumor has been documented in numerous neoplasms including: renal, ovarian, prostate, lung, gastroesophageal, colorectal, thyroid, oral and laryngeal carcinomas. In breast carcinoma, heterogeneity has been documented with respect to hormone receptors and DNA indices in a limited series of tumors. Tumors in this study are mapped and analyzed visually via image analysis systems. The rationale behind this method (as opposed to flow cytometry for DNA and conventional dextran-charcoal for ER/PR) is to sample multiple, discrete regions of tumor including the tumor/host tissue interface. This discrete region method most closely simulates the type and amount of tissues currently sent for analyses by conventional methods. Also, visual mapping allows for correlation with histopathological grade of specific regions. In the cell imaging laboratory, we are currently measuring simultaneous parameters and studying intraparametric relationships as well as looking for correlates to histopathologic features and clinical outcomes.
This physician has no reported relationships with industry.
Representative Publications
Dodd LG, Major NM. Fine-needle aspiration cytology of articular and periarticular lesions. Cancer. 2002 Jun 25;96(3):157-65.
(2002)
Abstract
Dodd LG, Scully SP, Cothran RL, Harrelson JM. Utility of fine-needle aspiration in the diagnosis of primary osteosarcoma. Diagn Cytopathol. 2002 Dec;27(6):350-3.
(2002)
Abstract
Dodd LG, Martinez S. Fine-needle aspiration cytology of pseudosarcomatous lesions of soft tissue. Diagn Cytopathol. 2001 Jan;24(1):28-35.
(2001)
Abstract
Keenlyside RA, Collins CL, Hancock JS, Gagnon MC, Cohn RD, Menoff AL, Dodd LG, Kurtycz DF, Hearn TL, Baker EL Jr. Do proficiency test results correlate with the work performance of screeners who screen Papanicolaou smears? Am J Clin Pathol. 1999 Dec;112(6):769-76.
(1999)
Abstract
Dodd LG, Farrell TA, Layfield LJ. Mucinous cystic tumor of the pancreas: an analysis of FNA characteristics with an emphasis on the spectrum of malignancy associated features. Diagn Cytopathol. 1995 Mar;12(2):113-9.
(1995)
Abstract
Dodd LG, Sneige N, Reece GP, Fornage B. Fine-needle aspiration cytology of silicone granulomas in the augmented breast. Diagn Cytopathol. 1993 Oct;9(5):498-502.
(1993)
Abstract
Dodd LG, Sneige N, Villarreal Y, Fanning CV, Staerkel GA, Caraway NP, Silva EG, Katz RL. Quality-assurance study of simultaneously sampled, non-correlating cervical cytology and biopsies. Diagn Cytopathol. 1993;9(2):138-44.
(1993)
Abstract
Dodd LG, Rosenthal DL, Cancilla P. A 35-year experience with the post-sophomore fellowship in pathology: analysis of its effectiveness as a recruitment resource. Hum Pathol. 1992 Apr;23(4):407-10.
(1992)
Abstract
