Department / Division
Medicine / Medicine - Hematology
Durham, NC 27710
Internal medicine; general adult hematology; hematological problems during pregnancy; anemias, including iron and B12 deficiencies and hemolytic anemias; hemoglobinopathies, particularly sickle cell and thalassemias; myeloproliferatic disorders and chronic leukemias (CML, CLL)
Dr. De Castro is an assistant professor of medicine with the Division of Hematology in the Department of Medicine at Duke University. She is the clinical director of the adult comprehensive sickle cell clinic. Her translational research projects involve the evaluation of sickle red cell adhesion to laminin and its pathophysiological significance. In, addition, she has been the PI of more than 10 NIH or industry sponsored clinical studies on SCD and she is currently the Duke/UNC Sickle Cell Scholar, funded primarily through the Duke/UNC Sickle Cell Center.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Edwards, CL; Scales, MT; Loughlin, C; Bennett, GG; Harris-Peterson, S; De Castro, LM; Whitworth, E; Abrams, M; Feliu, M; Johnson, S; Wood, M; Harrison, O; Killough, A. A brief review of the pathophysiology, associated pain, and psychosocial issues in sickle cell disease. International Journal of Behavioral Medicine. 2005;12:171-179. (2005) Abstract
Zen, Q; Batchvarova, M; Twyman, CA; Eyler, CE; Qiu, H; De Castro, LM; Telen, MJ. B-CAM/LU expression and the role of B-CAM/LU activation in binding of low- and high-density red cells to laminin in sickle cell disease. American Journal of Hematology. 2004;75:63-72. (2004) Abstract