Karen E. Welty-Wolf, MD

Department / Division:
Medicine / Pulmonary, Allergy, and Critical Care Medicine

Address:
DUMC 3518
Durham, NC 27710

Appointment Telephone:
919-668-7630

Office Telephone:
919-684-4938

Fax Telephone:
919-684-6002

• MD, Duke University School of Medicine, 1986

• Internal Medicine, Duke University Medical Center, 1986-1989
• Pulmonary and Critical Care Medicine, Infectious Diseases, Duke University Medical Center, 1989-1993

Clinical Interests:
Critical care, acute lung injury, and acute respiratory distress syndrome, sepsis; infectious diseases, including pulmonary and nosocomial infections; opportunistic infections in immuno-compromised hosts; acute and chronic respiratory diseases

Research Interests:
Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis.  Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis.  In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury.  Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria.  Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Representative Publications:
5) Welty-Wolf KE, SG Simonson, YC Huang, JD Crapo, MS Carraway, S Kantrow and CA Piantadosi. Aerosolized manganese superoxide dismutase decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis. J Appl Physiol. In press, 1997. (1997)

4) Huang Y-CT, PJ Fracica, SG Simonson, JD Crapo, SL Young, KE Welty-Wolf, RE Moon and CA Piantadosi. Mechanisms of hypoxemia in gram negative sepsis with fluid resuscitation in primates. Respir Physiol 105:109-121, 1996. (1996)

3) Welty-Wolf KE, SG Simonson, Y-CT Huang, PJ Fracica, JW Patterson and CA Piantadosi. Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis. Shock 5:378-384, 1996 (1996)

2) Piantadosi CA, PJ Fracica, FG Duhaylongsod, Y-CT Huang, KE Welty-wolf, JD Crapo and SL Young. Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis. J Appl Physiol 78:1823-1831, 1995. (1995)

I) Simonson SG, K Welty-Wolf, YC Huang, JA Griebel, PJ Fracica and CA Piantadosi. Altered mitochondrial redox responses in gram negative septic shock in primates. Circ Shock 43:34-43, 1994. (1994)