Physicians

Department / Division
Medicine / Medicine-Pulmonary

Address
DUMC 3518
Durham, NC 27710

Appointment Telephone
919-668-7630

Office Telephone
919-684-4938

Fax Telephone
919-684-6002

Training

• MD, Duke University School of Medicine, 1986

Residency

• Internal Medicine, Duke University Medical Center, 1986-1989
• Pulmonary and Critical Care Medicine, Infectious Diseases, Duke University Medical Center, 1989-1993

Clinical Interests
Critical care, acute lung injury, and acute respiratory distress syndrome, sepsis; infectious diseases, including pulmonary and nosocomial infections; opportunistic infections in immuno-compromised hosts; acute and chronic respiratory diseases

Research Interests
Dr. Welty-Wolf studies (1) pathophysiology and treatment of acute lung injury and (2) multiple organ failure and disordered energy metabolism in sepsis.  Injury models include hyperoxic lung injury and ARDS with multiple organ failure due to sepsis.  In addition to evaluating mechanisms of lung injury in sepsis, current studies are being conducted to evaluate the potential role of monoclinal antibodies to neutrophil adhesion molecules in the prevention of this injury.  Other sepsis work includes evaluating mechanisms of oxidative damage to mitochondria.  Additional research efforts include evaluating the use of human recombinant manganese superoxide dismutase in preventing hyperoxic lung injury.

Industry Relationships and Collaborations (What's this?)

This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Altor Bioscience Corporation

Representative Publications
5) Welty-Wolf KE, SG Simonson, YC Huang, JD Crapo, MS Carraway, S Kantrow and CA Piantadosi. Aerosolized manganese superoxide dismutase decreases hyperoxic pulmonary injury in primates. II. Morphometric analysis. J Appl Physiol. In press, 1997. (1997)

3) Welty-Wolf KE, SG Simonson, Y-CT Huang, PJ Fracica, JW Patterson and CA Piantadosi. Ultrastructural changes in skeletal muscle mitochondria in gram-negative sepsis. Shock 5:378-384, 1996 (1996)

4) Huang Y-CT, PJ Fracica, SG Simonson, JD Crapo, SL Young, KE Welty-Wolf, RE Moon and CA Piantadosi. Mechanisms of hypoxemia in gram negative sepsis with fluid resuscitation in primates. Respir Physiol 105:109-121, 1996. (1996)

2) Piantadosi CA, PJ Fracica, FG Duhaylongsod, Y-CT Huang, KE Welty-wolf, JD Crapo and SL Young. Artificial surfactant attenuates hyperoxic lung injury in primates. II. Morphometric analysis. J Appl Physiol 78:1823-1831, 1995. (1995)

I) Simonson SG, K Welty-Wolf, YC Huang, JA Griebel, PJ Fracica and CA Piantadosi. Altered mitochondrial redox responses in gram negative septic shock in primates. Circ Shock 43:34-43, 1994. (1994)