Department / Division
Pediatrics / Pediatrics-Allergy/Immunology
Durham, NC 27710
Primary immunodeficiency, allergic diseases, bone-marrow transplantation in SCID
My overall research interests are studying T cell development and defining the molecular bases of inherited immunodeficiency diseases. We are using standard candidate gene analysis approaches as well as new high throughput genome-wide sequencing, bioinformatics and functional screening in zebrafish and murine models in our work. Using these strategies we have recently reported a new molecular etiology of severe combined immunodeficiency (SCID), CD3 zeta chain deficiency. In collaboration with Dr. Wesley Burks we are also examining changes in T cell transcription patterns following treatment for peanut allergy using genome wide oligonucleotide microarrays.
This faculty member has no reported relationships with industry.
Kearse, KP; Roberts, JL; Munitz, TI; Wiest, DL; Nakayama, T; Singer, A. Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells. The EMBO Journal. 1994;13:4504-4514. (1994) Abstract