Department / Division:
Medicine / Pulmonary, Allergy, and Critical Care Medicine

Address:
DUMC 103004
Durham, NC 27710

Appointment Telephone:
919-668-7630

Office Telephone:
919-684-4588

Fax Telephone:
919-684-5266

• MD, University of Texas Medical Branch School of Medicine, 1996

• Internal Medicine, University of Texas Medical Branch, 1999

• Pulmonary and Critical Care Medicine, Duke University Medical Center, 2004

Clinical Interests:
Asthma, COPD, sarcoid, environmental lung disease

Research Interests:
John W. Hollingsworth, MD, is an Assistant Professor in the Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine at Duke University Medical Center.  He is a graduate of the University of Texas Medical Branch.  He completed his residency and chief residency in Internal Medicine at University of Texas Medical Branch.  His fellowship training was completed in Pulmonary and Critical Care Medicine at Duke University Medical Center.  Dr. Hollingsworth completed his post-doctoral research training in the laboratory of Dr. David A. Schwartz in 2004, where he has characterized the role of toll-like receptor 4 in inhaled environmental toxin exposure.  The broad objective of ongoing studies is to better understand the role of environmental exposures on genetic and epigenetic regulation of complex heritable diseases.  Current studies investigate the role of maternal diet and epigenetic regulation of allergic asthma.  In addition, we study the complex interaction between the innate immune system and the common inhaled toxicant, ozone.  Current studies are focused on both understanding the role of innate immunity in environmental airways disease and how exposure to ambient ozone can modify subsequent innate/adaptive immune response in the lung.    These lines of investigation will help us better understand the mechanisms, which lead to increased respiratory and cardiovascular mortality after exposure to ambient ozone.  

Representative Publications:
Li Z, Garantziotis S, Jia W, Potts EN, Lalani S, Liu Z, He YW, Foster WM, Hollingsworth JW. The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace. J Leukoc Biol. 2009 Jan;85(1):124-31. (2009) Abstract

Garantziotis S, Li Z, Potts EN, Kimata K, Zhuo L, Morgan DL, Savani RC, Noble PW, Foster WM, Schwartz DA, Hollingsworth JW. Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. J Biol Chem. 2009 Apr 24;284(17):11309-17. (2009) Abstract

Hollingsworth JW, Maruoka S, Boon K, Garantziotis S, Li Z, Tomfohr J, Bailey N, Potts EN, Whitehead G, Brass DM, Schwartz DA. In utero supplementation with methyl donors enhances allergic airway disease in mice. J Clin Invest. 2008 Oct;118(10):3462-9. (2008) Abstract

Brass DM, Hollingsworth JW, Cinque M, Li Z, Potts E, Toloza E, Foster WM, Schwartz DA. Chronic LPS inhalation causes emphysema-like changes in mouse lung that are associated with apoptosis. Am J Respir Cell Mol Biol. 2008 Nov;39(5):584-90. (2008) Abstract

Hollingsworth JW, Whitehead G, Berman KG, Tekippe EM, Gilmour MI, Larkin JE, Quackenbush J, Schwartz DA. Genetic basis of murine antibacterial defense to streptococcal lung infection. Immunogenetics. 2007 Sep;59(9):713-24. (2007) Abstract

Hollingsworth JW, Maruoka S, Li Z, Potts EN, Brass DM, Garantziotis S, Fong A, Foster WM, Schwartz DA. Ambient ozone primes pulmonary innate immunity in mice. J Immunol. 2007 Oct 1;179(7):4367-75. (2007) Abstract

Hollingsworth JW, Li Z, Brass DM, Garantziotis S, Timberlake SH, Kim A, Hossain I, Savani RC, Schwartz DA. CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease. Am J Respir Cell Mol Biol. 2007 Aug;37(2):248-53. (2007) Abstract

Hollingsworth JW, Whitehead GS, Lin KL, Nakano H, Gunn MD, Schwartz DA, Cook DN. TLR4 signaling attenuates ongoing allergic inflammation. J Immunol. 2006 May 15;176(10):5856-62. (2006) Abstract

Hollingsworth JW, Chen BJ, Brass DM, Berman K, Gunn MD, Cook DN, Schwartz DA. The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. Am J Respir Crit Care Med. 2005 Apr 15;171(8):806-13. (2005) Abstract

Hollingsworth JW 2nd, Cook DN, Brass DM, Walker JK, Morgan DL, Foster WM, Schwartz DA. The role of Toll-like receptor 4 in environmental airway injury in mice. Am J Respir Crit Care Med. 2004 Jul 15;170(2):126-32. (2004) Abstract

Cook DN, Hollingsworth JW Jr, Schwartz DA. Toll-like receptors and the genetics of innate immunity. Curr Opin Allergy Clin Immunol. 2003 Dec;3(6):523-9. (2003) Abstract