Physicians

Chief, Division of Infectious Diseases

Departments / Divisions

• Medicine / Medicine-Infectious Diseases
• Molecular Genetics and Microbiology

Address
DUMC 3353
Durham, NC 27710

Appointment Telephone
919-668-3271

Office Telephone
919-684-6854

Fax Telephone
919-684-8902

Training

• MD, Medical College of Ohio (University of Toledo College of Medicine), 1974

Residency

• Internal Medicine, University of Michigan Medical Center–Ann Arbor, 1975-1977
• Infectious Diseases, Duke University Medical Center, 1977-1980

Clinical Interests
Fungal infections

Research Interests
Research in my laboratory focuses around several aspects of medical mycology. We are investigating antifungal agents (new and old) in animal models of candida and cryptococcal infections. We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome. Our basic science project examines the molecular pathogenesis of cryptococcal infections. We have developed a molecular foundation for C. neoformans, including transformation systems, gene disruptions, differential gene expression screens, and cloning pathogenesis genes. The goal of this work is to use C. neoformans as a model yeast system to identify molecular targets for antifungal drug development. There are a series of clinical trials in fungal infections which are being coordinated through this laboratory and my work also includes a series of antibiotic trials in various aspects of infections. Finally, we have now been awarded a NIH sponsored Mycology Unit for 5 years with 6 senior investigators which is focused on C. neoformans as a pathogenic model system, but will include multiple areas of medical mycology from diagnosis to treatment.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.