Department / Division:
Radiation Oncology

Address:
DUMC 3085
Durham, NC 27710

Appointment Telephone:
919-660-2100

Office Telephone:
919-668-5213

Fax Telephone:
919-668-7345

• MD, University of Texas School of Medicine at San Antonio, 1999

• Internal Medicine, UNC Hospitals, 1999-2000
• Radiation Oncology, Duke University Medical Center, 2000-2004

• PhD, Chemical Engineering, Rice University (Texas), 1979

Clinical Interests:
Radiation oncology, particularly the treatment of cancers and benign tumors of the central nervous system, base of skull and head/neck; stereotactic radiosurgery, stereotactic radiotherapy and other highly conformal techniques employing spatiotemporal optimization

Research Interests:
Malignant and benign tumors of the brain, spine and base of skull. Mathematical modelling of tumor metabolism, mass transfer and the response to ionizing radiation.  Enhancing clinical outcome in stereotactic radiosurgery and stereotactic body radiotherapy.

Representative Publications:
Wu QJ, Wang Z, Kirkpatrick JP, Chang Z, Meyer JJ, Lu M, Huntzinger C, Yin FF. Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions. Radiat Oncol. 2009;4:3. (2009) Abstract

Wang Z, Nelson JW, Yoo S, Wu QJ, Kirkpatrick JP, Marks LB, Yin FF. Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2009 Feb 1;73(2):571-7. (2009) Abstract

Reese AS, Das SK, Kirkpatrick JP, Marks LB. Quantifying the dosimetric trade-offs when using intensity-modulated radiotherapy to treat concave targets containing normal tissues. Int J Radiat Oncol Biol Phys. 2009 Feb 1;73(2):585-93. (2009) Abstract

Nelson JW, Yoo DS, Sampson JH, Isaacs RE, Larrier NA, Marks LB, Yin FF, Wu QJ, Wang Z, Kirkpatrick JP. Stereotactic body radiotherapy for lesions of the spine and paraspinal regions. Int J Radiat Oncol Biol Phys. 2009 Apr 1;73(5):1369-75. (2009) Abstract

Hahn CA, Zhou SM, Raynor R, Tisch A, Light K, Shafman T, Wong T, Kirkpatrick J, Turkington T, Hollis D, Marks LB. Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction. Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1082-7. (2009) Abstract

Chino JP, Sampson JH, Tucci DL, Brizel DM, Kirkpatrick JP. Paraganglioma of the Head and Neck: Long-term Local Control with Radiotherapy. Am J Clin Oncol. 2009 May 8. (2009) Abstract

Yin FF, Wang Z, Yoo S, Wu QJ, Kirkpatrick J, Larrier N, Meyer J, Willett CG, Marks LB. Integration of cone-beam CT in stereotactic body radiation therapy. Technol Cancer Res Treat. 2008 Apr;7(2):133-9. (2008) Abstract

Kirkpatrick JP, Rabbani ZN, Bentley RC, Hardee ME, Karol S, Meyer J, Oosterwijk E, Havrilesky L, Secord AA, Vujaskovic Z, Dewhirst MW, Jones EL. Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer. Biomark Insights. 2008;3:45-55. (2008) Abstract

Kirkpatrick JP, Meyer JJ, Marks LB. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Semin Radiat Oncol. 2008 Oct;18(4):240-3. (2008) Abstract

Kirkpatrick JP, Dewhirst MW. Analytic solution to steady-state radial diffusion of a substrate with first-order reaction kinetics in the tissue of a Krogh's cylinder. Radiat Res. 2008 Mar;169(3):350-4. (2008) Abstract

Miles EF, Kelsey CR, Kirkpatrick JP, Marks LB. Estimating the magnitude and field-size dependence of radiotherapy-induced mortality and tumor control after postoperative radiotherapy for non-small-cell lung cancer: calculations from clinical trials. Int J Radiat Oncol Biol Phys. 2007 Jul 15;68(4):1047-52. (2007) Abstract

Kasibhatla M, Kirkpatrick JP, Brizel DM. How much radiation is the chemotherapy worth in advanced head and neck cancer? Int J Radiat Oncol Biol Phys. 2007 Aug 1;68(5):1491-5. (2007) Abstract

Yin FF, Das S, Kirkpatrick J, Oldham M, Wang Z, Zhou SM. Physics and imaging for targeting of oligometastases. Semin Radiat Oncol. 2006 Apr;16(2):85-101. (2006) Abstract

Soper JT, Spillman M, Sampson JH, Kirkpatrick JP, Wolf JK, Clarke-Pearson DL. High-risk gestational trophoblastic neoplasia with brain metastases: Individualized multidisciplinary therapy in the management of four patients. Gynecol Oncol. 2006 Nov 28. (2006) Abstract

Oldham M, Sakhalkar H, Oliver T, Wang YM, Kirkpatrick J, Cao Y, Badea C, Johnson GA, Dewhirst M. Three-dimensional imaging of xenograft tumors using optical computed and emission tomography.  Med Phys.  2006 Sep;33(9):3193-202. (2006) Abstract

Meyer JJ, Marks LB, Halperin EC, Kirkpatrick JP. Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation. Radiat Oncol. 2006;1:48. (2006) Abstract

Koontz BF, Kirkpatrick JP, Clough RW, Prosnitz RG, Gockerman JP, Moore JO, Prosnitz LR. Combined-modality therapy versus radiotherapy alone for treatment of early-stage Hodgkin's disease: cure balanced against complications. J Clin Oncol. 2006 Feb 1;24(4):605-11. (2006) Abstract

Kirkpatrick JP. Tumor hypoxia and prognosis in human gliomas. Cancer J. 2006 Nov-Dec;12(6):451-4. (2006) Abstract

Kirkpatrick JP, Hardee ME, Snyder SA, Peltz CM, Zhao Y, Brizel DM, Dewhirst MW, Blackwell KL. The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma. Radiat Res. 2006 Feb;165(2):192-201. (2006) Abstract

Hardee ME, Arcasoy MO, Blackwell KL, Kirkpatrick JP, Dewhirst MW. Erythropoietin biology in cancer. Clin Cancer Res. 2006 Jan 15;12(2):332-9. (2006) Abstract

Kirkpatrick JP, Anscher MS. Radiotherapy for locally recurrent prostate cancer. Clin Adv Hematol Oncol. 2005 Dec;3(12):933-42. (2005) Abstract

Hardee ME, Kirkpatrick JP, Shan S, Snyder SA, Vujaskovic Z, Rabbani ZN, Dewhirst MW, Blackwell KL. Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis. Br J Cancer. 2005 Dec 12;93(12):1350-5. (2005) Abstract

Zhang X, Kon T, Wang H, Li F, Huang Q, Rabbani ZN, Kirkpatrick JP, Vujaskovic Z, Dewhirst MW, Li CY. Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha. Cancer Res. 2004 Nov 15;64(22):8139-42. (2004) Abstract

Kirkpatrick JP, Marks LB. Modeling killing and repopulation kinetics of subclinical cancer: direct calculations from clinical data. Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):641-54. (2004) Abstract

Kirkpatrick JP, Cárdenas-Navia LI, Dewhirst MW. Predicting the effect of temporal variations in PO2 on tumor radiosensitivity. Int J Radiat Oncol Biol Phys. 2004 Jul 1;59(3):822-33. (2004) Abstract

Kirkpatrick JP, Brizel DM, Dewhirst MW. A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics. Radiat Res. 2003 Mar;159(3):336-44. (2003) Abstract

Kang SK, Kirkpatrick JP, Halperin EC. Low-dose radiation for posttransplant lymphoproliferative disorder. Am J Clin Oncol. 2003 Apr;26(2):210-4. (2003) Abstract

Blackwell KL, Kirkpatrick JP, Snyder SA, Broadwater G, Farrell F, Jolliffe L, Brizel DM, Dewhirst MW. Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin. Cancer Res. 2003 Oct 1;63(19):6162-5. (2003) Abstract

Kirkpatrick JP, McIntire LV, Moake JL, Peterson DM. Metabolic requirements of contractile force generation in platelet rich plasma - a rheological study. Biorheology. 1980;17(5-6):411-8. (1980) Abstract

Kirkpatrick JP, McIntire LV, Moake JL, Cimo PL. Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents. Thromb Haemost. 1980 Feb 29;42(5):1483-9. (1980) Abstract

Kirkpatrick JP, McIntire LV, Moake JL. Streptokinase-induced degradation of crosslinked and uncrosslinked clots. Thromb Res. 1978 Sep;13(3):569-75. (1978) Abstract