John P. Kirkpatrick, MD, PhD
- Radiation Oncology / Radiation Onc-Clinical Sup
- Surgery / Neurosurgery
Address
DUMC 3085
Durham, NC 27710
Appointment Telephone
919-660-2100
Office Telephone
919-668-7342
Fax Telephone
919-668-7345
- MD, University of Texas School of Medicine–San Antonio, 1999
- Internal Medicine, UNC Hospitals, 1999-2000
- Radiation Oncology, Duke University Medical Center, 2000-2004
- PhD, Chemical Engineering, Rice University (Texas), 1979
Clinical Interests
Radiation oncology, particularly the treatment of cancers and benign tumors of
the central nervous system, base of skull and head/neck; stereotactic
radiosurgery, stereotactic radiotherapy and other highly conformal techniques
employing spatiotemporal optimization
Research Interests
Malignant and benign tumors of the brain, spine and base of skull. Mathematical modelling of tumor metabolism, mass transfer and the response to ionizing radiation. Enhancing clinical outcome in stereotactic radiosurgery, fractionated stereotactic radiotherapy and stereotactic body radiotherapy.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
- ClearSight Radiotherapy Products LLC
- Genentech, Inc (Roche Holding)
- Varian Medical Systems
Representative Publications
Chang, Z; Wang, Z; Ma, J; O'Daniel, JC; Kirkpatrick, J; Yin, FF. 6D image guidance for spinal non-invasive stereotactic body radiation therapy: Comparison between ExacTrac X-ray 6D with kilo-voltage cone-beam CT. Radiotherapy and Oncology. 2010;95:116-121.
(2010)
Abstract
Kelsey, CR; Mukundan, S; Wang, Z; Hahn, CA; Soher, BJ; Kirkpatrick, JP. Assessing neurotoxicity from the low-dose radiation component of radiosurgery using magnetic resonance spectroscopy. Neuro-Oncology. 2010;12:145-152.
(2010)
Abstract
Kirkpatrick, JP; van der Kogel, AJ; Schultheiss, TE. Radiation dose-volume effects in the spinal cord. International Journal of Radiation: Oncology - Biology - Physics. 2010;76:S42-S49.
(2010)
Abstract
Mayo, C; Martel, MK; Marks, LB; Flickinger, J; Nam, J; Kirkpatrick, J. Radiation dose-volume effects of optic nerves and chiasm. International Journal of Radiation: Oncology - Biology - Physics. 2010;76:S28-S35.
(2010)
Abstract
Sperduto, PW; Chao, ST; Sneed, PK; Luo, X; Suh, J; Roberge, D; Bhatt, A; Jensen, AW; Brown, PD; Shih, H; Kirkpatrick, J; Schwer, A; Gaspar, LE; Fiveash, JB; Chiang, V; Knisely, J; Sperduto, CM; Mehta, M. Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients. International Journal of Radiation: Oncology - Biology - Physics. 2010;77:655-661.
(2010)
Abstract
Hahn, CA; Zhou, SM; Raynor, R; Tisch, A; Light, K; Shafman, T; Wong, T; Kirkpatrick, J; Turkington, T; Hollis, D; Marks, LB. Dose-dependent effects of radiation therapy on cerebral blood flow, metabolism, and neurocognitive dysfunction. International Journal of Radiation: Oncology - Biology - Physics. 2009;73:1082-1087.
(2009)
Abstract
Kirkpatrick, JP; Brenner, DJ; Orton, CG. Point/Counterpoint. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Medical Physics. 2009;36:3381-3384.
(2009)
Abstract
Nelson, JW; Yoo, DS; Sampson, JH; Isaacs, RE; Larrier, NA; Marks, LB; Yin, FF; Wu, QJ; Wang, Z; Kirkpatrick, JP. Stereotactic body radiotherapy for lesions of the spine and paraspinal regions. International Journal of Radiation: Oncology - Biology - Physics. 2009;73:1369-1375.
(2009)
Abstract
Wang, Z; Nelson, JW; Yoo, S; Wu, QJ; Kirkpatrick, JP; Marks, LB; Yin, FF. Refinement of treatment setup and target localization accuracy using three-dimensional cone-beam computed tomography for stereotactic body radiotherapy. International Journal of Radiation: Oncology - Biology - Physics. 2009;73:571-577.
(2009)
Abstract
Wu, QJ; Wang, Z; Kirkpatrick, JP; Chang, Z; Meyer, JJ; Lu, M; Huntzinger, C; Yin, FF. Impact of collimator leaf width and treatment technique on stereotactic radiosurgery and radiotherapy plans for intra- and extracranial lesions. Radiation Oncology. 2009;4:3.
(2009)
Abstract
Kirkpatrick, JP; Dewhirst, MW. Analytic solution to steady-state radial diffusion of a substrate with first-order reaction kinetics in the tissue of a Krogh's cylinder. Radiation Research. 2008;169:350-354.
(2008)
Abstract
Kirkpatrick, JP; Meyer, JJ; Marks, LB. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Seminars in Radiation Oncology. 2008;18:240-243.
(2008)
Abstract
Kirkpatrick, JP; Rabbani, ZN; Bentley, RC; Hardee, ME; Karol, S; Meyer, J; Oosterwijk, E; Havrilesky, L; Secord, AA; Vujaskovic, Z; Dewhirst, MW; Jones, EL. Elevated CAIX Expression is Associated with an Increased Risk of Distant Failure in Early-Stage Cervical Cancer. Biomarker Insights. 2008;3:45-55.
(2008)
Abstract
Kasibhatla, M; Kirkpatrick, JP; Brizel, DM. How much radiation is the chemotherapy worth in advanced head and neck cancer?. International Journal of Radiation: Oncology - Biology - Physics. 2007;68:1491-1495.
(2007)
Abstract
Soper, JT; Spillman, M; Sampson, JH; Kirkpatrick, JP; Wolf, JK; Clarke-Pearson, DL. High-risk gestational trophoblastic neoplasia with brain metastases: individualized multidisciplinary therapy in the management of four patients. Gynecologic Oncology. 2007;104:691-694.
(2007)
Abstract
Hardee, ME; Arcasoy, MO; Blackwell, KL; Kirkpatrick, JP; Dewhirst, MW. Erythropoietin biology in cancer. Clinical Cancer Research. 2006;12:332-339.
(2006)
Abstract
Kirkpatrick, JP. Tumor hypoxia and prognosis in human gliomas. The Cancer Journal. 2006;12:451-454.
(2006)
Abstract
Kirkpatrick, JP; Hardee, ME; Snyder, SA; Peltz, CM; Zhao, Y; Brizel, DM; Dewhirst, MW; Blackwell, KL. The effect of darbepoetin alfa on growth, oxygenation and radioresponsiveness of a breast adenocarcinoma. Radiation Research. 2006;165:192-201.
(2006)
Abstract
Koontz, BF; Kirkpatrick, JP; Clough, RW; Prosnitz, RG; Gockerman, JP; Moore, JO; Prosnitz, LR. Combined-modality therapy versus radiotherapy alone for treatment of early-stage Hodgkin's disease: cure balanced against complications. Journal of Clinical Oncology. 2006;24:605-611.
(2006)
Abstract
Meyer, JJ; Marks, LB; Halperin, EC; Kirkpatrick, JP. Kinetic modeling of tumor growth and dissemination in the craniospinal axis: implications for craniospinal irradiation. Radiation Oncology. 2006;1:48.
(2006)
Abstract
Yin, FF; Das, S; Kirkpatrick, J; Oldham, M; Wang, Z; Zhou, SM. Physics and imaging for targeting of oligometastases. Seminars in Radiation Oncology. 2006;16:85-101.
(2006)
Abstract
Hardee, ME; Kirkpatrick, JP; Shan, S; Snyder, SA; Vujaskovic, Z; Rabbani, ZN; Dewhirst, MW; Blackwell, KL. Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis. British Journal of Cancer. 2005;93:1350-1355.
(2005)
Abstract
Kirkpatrick, JP; Anscher, MS. Radiotherapy for locally recurrent prostate cancer. Clinical Advances in Hematology and Oncology. 2005;3:933-942.
(2005)
Abstract
Kirkpatrick, JP; Cárdenas-Navia, LI; Dewhirst, MW. Predicting the effect of temporal variations in PO2 on tumor radiosensitivity. International Journal of Radiation: Oncology - Biology - Physics. 2004;59:822-833.
(2004)
Abstract
Kirkpatrick, JP; Marks, LB. Modeling killing and repopulation kinetics of subclinical cancer: direct calculations from clinical data. International Journal of Radiation: Oncology - Biology - Physics. 2004;58:641-654.
(2004)
Abstract
Blackwell, KL; Kirkpatrick, JP; Snyder, SA; Broadwater, G; Farrell, F; Jolliffe, L; Brizel, DM; Dewhirst, MW. Human recombinant erythropoietin significantly improves tumor oxygenation independent of its effects on hemoglobin. Cancer Research. 2003;63:6162-6165.
(2003)
Abstract
Kang, SK; Kirkpatrick, JP; Halperin, EC. Low-dose radiation for posttransplant lymphoproliferative disorder. American Journal of Clinical Oncology: cancer clinical trials. 2003;26:210-214.
(2003)
Abstract
Kirkpatrick, JP; Brizel, DM; Dewhirst, MW. A mathematical model of tumor oxygen and glucose mass transport and metabolism with complex reaction kinetics. Radiation Research. 2003;159:336-344.
(2003)
Abstract
Kirkpatrick, JP; McIntire, LV; Moake, JL; Cimo, PL. Differential effects of cytochalasin B on platelet release, aggregation and contractility: evidence against a contractile mechanism for the release of platelet granular contents. Thrombosis and Haemostasis. 1980;42:1483-1489.
(1980)
Abstract
Kirkpatrick, JP; McIntire, LV; Moake, JL; Peterson, DM. Metabolic requirements of contractile force generation in platelet rich plasma - a rheological study. Biorheology: an international journal. 1980;17:411-418.
(1980)
Abstract
Kirkpatrick, JP; McIntire, LV; Moake, JL. Streptokinase-induced degradation of crosslinked and uncrosslinked clots. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 1978;13:569-575.
(1978)
Abstract
