John H.P. Alexander, MD, MHS
Department / Division
Medicine /
Medicine - Cardiology
Address
DUMC 3300
Durham, NC 27710
Appointment Telephone
919-681-5816
Office Telephone
919-668-8955
Fax Telephone
919-668-7085
- MD, University of Pennsylvania School of Medicine, 1993
- Internal Medicine, Brigham and Women's Hospital (Massachusetts), 1993-1996
- Cardiovascular Disease, Duke University Medical Center, 1996-2000
- MHS, Duke University, 2001
Clinical Interests
General adult cardiology, acute and general cardiovascular disease, coronary artery disease, chest pain, unstable angina, myocardial infarction, acute coronary syndromes, heart failure, hypertension, echocardiography, transesophageal echocardiography, stress echocardiography, valvular heart disease
Research Interests
My major research interests are in the pathyophysiology and therapeutics of acute coronary syndromes and chronic coronary artery disease with a particular interest in clinical research in cardiac surgery. Methodologically, I focus on early phase clinical research and site based research techniques.
This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
- AstraZeneca
- Bayer
- Boehringer Ingelheim
- Bristol-Myers Squibb
- CSL Behring AG
- Merck & Co. USA (not assoc'd with Merck KGaA)
- Novartis
- Ortho-McNeil Pharmceutical (Johnson & Johnson)
- Otsuka
- Regado Biosciences Inc
Representative Publications
Serebruany VL, Malinin AI, Callahan KP, Binbrek A, Van De Werf F, Alexander JH, Granger CB, Gurbel PA, . Effect of tenecteplase versus alteplase on platelets during the first 3 hours of treatment for acute myocardial infarction: the Assessment of the Safety and Efficacy of a New Thrombolytic Agent (ASSENT-2) platelet substudy. Am Heart J. 2003 Apr;145(4):636-42.
(2003)
Abstract
Akkerhuis KM, Alexander JH, Tardiff BE, Boersma E, Harrington RA, Lincoff AM, Simoons ML. Minor myocardial damage and prognosis: are spontaneous and percutaneous coronary intervention-related events different? Circulation. 2002 Feb 5;105(5):554-6.
(2002)
Abstract
Al-Khatib SM, Califf RM, Hasselblad V, Alexander JH, McCrory DC, Sugarman J. Medicine. Placebo-controls in short-term clinical trials of hypertension. Science. 2001 Jun 15;292(5524):2013-5.
(2001)
Abstract
Angeja BG, Alexander JH, Chin R, Li X, Barron HV, Armstrong PW, Granger CB, Van de Werf F, Gibson CM. Safety of the weight-adjusted dosing regimen of tenecteplase in the ASSENT-Trial. Am J Cardiol. 2001 Dec 1;88(11):1240-5.
(2001)
Abstract
Callahan KP, Malinin AI, Gurbel PA, Alexander JH, Granger CB, Serebruany VL. Platelet function and fibrinolytic agents: two sides of a coin? Cardiology. 2001;95(2):55-60.
(2001)
Abstract
Alexander JH, Sparapani RA, Mahaffey KW, Deckers JW, Newby LK, Ohman EM, Corbalán R, Chierchia SL, Boland JB, Simoons ML, Califf RM, Topol EJ, Harrington RA. Association between minor elevations of creatine kinase-MB level and mortality in patients with acute coronary syndromes without ST-segment elevation. PURSUIT Steering Committee. Platelet Glycoprotein IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy. JAMA. 2000 Jan 19;283(3):347-53.
(2000)
Abstract
McGuire DK, Hudson MP, East MA, Dyke CK, Cantor WJ, Battle J, Bahit MC, Al-Khatib SM, Alexander JH. Highlights from the american heart association 72nd scientific sessions: november 6 to 10, 1999 Am Heart J. 2000 Feb;139(2 Pt 1):359-70.
(2000)
Abstract
McGuire DK, Hudson MP, East MA, Dyke CK, Cantor WJ, Battle J, Bahit MC, Al-Khatib SM, Alexander JH. Highlights from the american heart association 72nd scientific sessions: november 6 to 10, 1999 Am Heart J. 2000 Feb;139(2 Pt 1):359-70.
(2000)
Abstract
Patel M, Han SS, Vaux K, Saalfeld J, Alexander JH. A protocol of early spiral computed tomography for the detection of stones in patients with renal colic has reduced the time to diagnosis and overall management costs. Aust N Z J Surg. 2000 Jan;70(1):39-42.
(2000)
Abstract
Alexander JH, Al-Khatib S, Cantor W, Greenbaum AB, Hudson MP, Kong DF, Shah M. Highlights from the American College of Cardiology 48th Annual Scientific Sessions: March 7 to 10, 1999. Am Heart J. 1999 Jul;138(1 Pt 1):175-90.
(1999)
Abstract
Alexander JH, Granger CB, Sadowski Z, Aylward PE, White HD, Thompson TD, Califf RM, Topol EJ. Prophylactic lidocaine use in acute myocardial infarction: incidence and outcomes from two international trials. The GUSTO-I and GUSTO-IIb Investigators. Am Heart J. 1999 May;137(5):799-805.
(1999)
Abstract
Alexander JH, Harrington RA, Tuttle RH, Berdan LG, Lincoff AM, Deckers JW, Simoons ML, Guerci A, Hochman JS, Wilcox RG, Kitt MM, Eisenberg PR, Califf RM, Topol EJ, Karsh K, Ruzyllo W, Stepinska J, Widimsky P, Boland JB, Armstrong PW. Prior aspirin use predicts worse outcomes in patients with non-ST-elevation acute coronary syndromes. PURSUIT Investigators. Platelet IIb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy. Am J Cardiol. 1999 Apr 15;83(8):1147-51.
(1999)
Abstract
Alexander JH, Kong DF, Cantor WJ. Highlights from the 71st American Heart Association Scientific Sessions: November 8 to 11, 1998. Am Heart J. 1999 Mar;137(3):555-74.
(1999)
Abstract
Pertusi RM, Godwin KS, House JK, Knebl JA, Alexander JH, Rubin BR, Forman MD. Gastropathy induced by nonsteroidal anti-inflammatory drugs: prescribing patterns among geriatric practitioners. J Am Osteopath Assoc. 1999 Jun;99(6):305-10.
(1999)
Abstract
Sadowski ZP, Alexander JH, Skrabucha B, Dyduszynski A, Kuch J, Nartowicz E, Swiatecka G, Kong DF, Granger CB. Multicenter randomized trial and a systematic overview of lidocaine in acute myocardial infarction. Am Heart J. 1999 May;137(5):792-8.
(1999)
Abstract
Alexander JH, Alexander K, Kong DF, Tung CY, Whellan D. Session highlights from the American Heart Association Scientific Sessions: November 9-12, 1997. Am Heart J. 1998 Jan;135(1):157-80.
(1998)
Abstract
Alexander JH, Greenbaum AB, Hudson MP, Kong DF, Miller JM, Tung CY, Whellan DJ. Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998. Am Heart J. 1998 Jul;136(1):176-9.
(1998)
Abstract
Alexander JH, Greenbaum AB, Hudson MP, Kong DF, Miller JM, Tung CY, Whellan DJ. Session highlights from the American College of Cardiology Scientific Sessions: March 29 to April 1, 1998. Am Heart J. 1998 Jun;135(6 Pt 1):1099-114.
(1998)
Abstract
Alexander JH, Harrington RA. Recent antiplatelet drug trials in the acute coronary syndromes. Clinical interpretation of PRISM, PRISM-PLUS, PARAGON A and PURSUIT. Drugs. 1998 Dec;56(6):965-76.
(1998)
Abstract
O'Neill GF, Alexander JH. Spontaneous bladder rupture in a patient with widespread superficial transitional cell carcinoma. Aust N Z J Surg. 1998 Jan;68(1):79.
(1998)
Abstract
Alexander JH, Harrington RA. Adjunctive Antiplatelet Therapy in Acute Myocardial Infarction: The Road to Improved Infarct-Related Artery Patency. J Thromb Thrombolysis. 1997;4(3/4):353-355.
(1997)
Abstract
Alexander JH, Harrington RA. Antiplatelet and antithrombin therapies in the acute coronary syndromes. Curr Opin Cardiol. 1997 Jul;12(4):427-37.
(1997)
Abstract
