Chief, Endocrine, Breast, and Oncologic Surgery

Department / Division:
Surgery / General Surgery

Address:
DUMC 2945
Durham, NC 27710

Appointment Telephone:
919-684-6849

Office Telephone:
919-668-1767

Fax Telephone:
919-668-4777

• MD, University of Florida College of Medicine, 1992

• General Surgery, Barnes Hospital/Washington University in St. Louis (Missouri), 1992-1998
• Endocrine Surgery, Royal Infirmary of Edinburgh (Scotland), 1997

• Surgical Oncology, Memorial Sloan-Kettering Cancer Center (New York), 1998-2000

• PhD, Pharmacology and Experimental Therapeutics, University of Florida, 1990

Clinical Interests:
Endocrine and oncologic surgery with emphasis on diseases of the thyroid, parathyroid, adrenal, and endocrine pancreas; minimally invasive endocrine surgery including minimally invasive radio-guided parathyroidectomy (MIRP), minimally invasive thyroidectomy, recurrent laryngeal nerve monitoring, and laparoscopic adrenalectomy; surgical oncology including breast cancer, melanoma, and sarcoma; clinical trials, neoadjuvant therapy for breast cancer, sentinel lymph-node biopsy

Research Interests:
Discovery, validation, and clinical translation of microarray biomarkers in breast cancer.
Molecular characterization of parathyroid tumors and hyperparathyroidism.

Representative Publications:
Tebbit CL, Zhai J, Untch BR, Ellis MJ, Dressman HK, Bentley RC, Baker JA, Marcom PK, Nevins JR, Marks JR, Olson JA Jr. Novel tumor sampling strategies to enable microarray gene expression signatures in breast cancer: a study to determine feasibility and reproducibility in the context of clinical care. Breast Cancer Res Treat. 2009 Feb 18. (2009) Abstract

Untch BR, Olson JA. Vitamin D deficiency and primary hyperparathyroidism: an association of uncertain cause and consequences. Surgery. 2008 Dec;144(6):860-1. (2008) Abstract

Olson JA Jr, McCall LM, Beitsch P, Whitworth PW, Reintgen DS, Blumencranz PW, Leitch AM, Saha S, Hunt KK, Giuliano AE, . Impact of immediate versus delayed axillary node dissection on surgical outcomes in breast cancer patients with positive sentinel nodes: results from American College of Surgeons Oncology Group Trials Z0010 and Z0011. J Clin Oncol. 2008 Jul 20;26(21):3530-5. (2008) Abstract

Olson JA Jr, Marcom PK. Benefit or bias? The role of surgery to remove the primary tumor in patients with metastatic breast cancer. Ann Surg. 2008 May;247(5):739-40. (2008) Abstract

Untch BR, Barfield ME, Dar M, Dixit D, Leight GS Jr, Olson JA Jr. Impact of 25-hydroxyvitamin D deficiency on perioperative parathyroid hormone kinetics and results in patients with primary hyperparathyroidism. Surgery. 2007 Dec;142(6):1022-6. (2007) Abstract

Untch BR, Barfield ME, Bason J, Olson JA Jr. Minimally invasive radio-guided surgery for primary hyperparathyroidism. Ann Surg Oncol. 2007 Dec;14(12):3401-2. (2007) Abstract

Sherman SI, Angelos P, Ball DW, Byrd D, Clark OH, Daniels GH, Dilawari RA, Ehya H, Farrar WB, Gagel RF, Kandeel F, Kloos RT, Kopp P, Lamonica DM, Loree TR, Lydiatt WM, McCaffrey J, Olson JA Jr, Ridge JA, Shah JP, Sisson JC, Tuttle RM, Urist MM, . Thyroid carcinoma. J Natl Compr Canc Netw. 2007 Jul;5(6):568-621. (2007) Abstract

Untch BR, Olson JA Jr. Anaplastic thyroid carcinoma, thyroid lymphoma, and metastasis to thyroid. Surg Oncol Clin N Am. 2006 Jul;15(3):661-79, x. (2006) Abstract

Dressman HK, Hans C, Bild A, Olson JA, Rosen E, Marcom PK, Liotcheva VB, Jones EL, Vujaskovic Z, Marks J, Dewhirst MW, West M, Nevins JR, Blackwell K. Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy. Clin Cancer Res. 2006 Feb 1;12(3 Pt 1):819-26. (2006) Abstract

Bild AH, Yao G, Chang JT, Wang Q, Potti A, Chasse D, Joshi MB, Harpole D, Lancaster JM, Berchuck A, Olson JA Jr, Marks JR, Dressman HK, West M, Nevins JR. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature. 2006 Jan 19;439(7074):353-7. (2006) Abstract

Safford SD, Coleman RE, Gockerman JP, Moore J, Feldman J, Onaitis MW, Tyler DS, Olson JA Jr. Iodine-131 metaiodobenzylguanidine treatment for metastatic carcinoid. Results in 98 patients. Cancer. 2004 Nov 1;101(9):1987-93. (2004) Abstract

Olson JA Jr. Application of microarray profiling to clinical trials in cancer. Surgery. 2004 Sep;136(3):519-23. (2004) Abstract

Safford SD, Coleman RE, Gockerman JP, Moore J, Feldman JM, Leight GS Jr, Tyler DS, Olson JA Jr. Iodine -131 metaiodobenzylguanidine is an effective treatment for malignant pheochromocytoma and paraganglioma. Surgery. 2003 Dec;134(6):956-62; discussion 962-3. (2003) Abstract

Olson JA Jr, Leight GS Jr. Surgical management of secondary hyperparathyroidism. Adv Ren Replace Ther. 2002 Jul;9(3):209-18. (2002) Abstract

West M, Blanchette C, Dressman H, Huang E, Ishida S, Spang R, Zuzan H, Olson JA Jr, Marks JR, Nevins JR. Predicting the clinical status of human breast cancer by using gene expression profiles. Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11462-7. (2001) Abstract

Moorman PG, Hamza A, Marks JR, Olson JA. Prognostic significance of the number of lymph nodes examined in patients with lymph node-negative breast carcinoma. Cancer. 2001 Jun 15;91(12):2258-62. (2001) Abstract

Olson JA Jr, Morris EA, Van Zee KJ, Linehan DC, Borgen PI. Magnetic resonance imaging facilitates breast conservation for occult breast cancer. Ann Surg Oncol. 2000 Jul;7(6):411-5. (2000) Abstract

Olson JA Jr, Jaques DP, Coit DG, Hwu WJ. Staging work-up and post-treatment surveillance of patients with melanoma. Clin Plast Surg. 2000 Jul;27(3):377-90, viii. (2000) Abstract

Olson JA Jr, Fey J, Winawer J, Borgen PI, Cody HS 3rd, Van Zee KJ, Petrek J, Heerdt AS. Sentinel lymphadenectomy accurately predicts nodal status in T2 breast cancer. J Am Coll Surg. 2000 Dec;191(6):593-9. (2000) Abstract

Olson JA Jr, DeBenedetti MK, Baumann DS, Wells SA Jr. Parathyroid autotransplantation during thyroidectomy. Results of long-term follow-up. Ann Surg. 1996 May;223(5):472-8; discussion 478-80. (1996) Abstract

Olson JA Jr, Shiverick KT, Ogilvie S, Buhi WC, Raizada MK. Developmental expression of rat insulin-like growth factor binding protein-2 by astrocytic glial cells in culture. Endocrinology. 1991 Aug;129(2):1066-74. (1991) Abstract

Olson JA Jr, Shiverick KT, Ogilvie S, Buhi WC, Raizada MK. Angiotensin II induces secretion of plasminogen activator inhibitor 1 and a tissue metalloprotease inhibitor-related protein from rat brain astrocytes. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1928-32. (1991) Abstract