Department / Division
Pediatrics / Pediatrics-Critical Care Med
Durham, NC 27710
Pediatric critical care medicine, acute lung injury
Iron concentrations are elevated in the airways of patients with inflammatory lung diseases such as cystic fibrosis and ARDS. The presence of iron in the airway catalyzes the production of highly reactive oxygen species (ROS) that cause cellular injury and trigger oxidant-mediated intracellular signaling. To limit oxidative stress, iron acquisition and its distribution must be tightly regulated. Airway epithelial cells normally take up iron and sequester it within ferritin to protect the lung’s extracellular milieu; however, many of these mechanisms remain unclear. The goals of our work are to more clearly define mechanisms of cellular iron transport in airway epithelial cells and to determine the role of disrupted iron homeostasis in the pathogenesis of inflammatory lung disease.
This faculty member has no reported relationships with industry.
Ozment, CP; Turi, JL. Iron overload following red blood cell transfusion and its impact on disease severity. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 2009;1790:694-701. (2009) Abstract
Turi, JL; Piantadosi, CA; Stonehuerner, JD; Ghio, AJ. Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport. Biometals. 2008;21:571-580. (2008) Abstract
Ghio, AJ; Turi, JL; Madden, MC; Dailey, LA; Richards, JD; Stonehuerner, JG; Morgan, DL; Singleton, S; Garrick, LM; Garrick, MD. Lung injury after ozone exposure is iron dependent. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2007;292:L134-L143. (2007) Abstract
Ghio, AJ; Turi, JL; Yang, F; Garrick, LM; Garrick, MD. Iron homeostasis in the lung. Biological Research. 2006;39:67-77. (2006) Abstract
Turi, JL; Wang, X; McKie, AT; Nozik-Grayck, E; Mamo, LB; Crissman, K; Piantadosi, CA; Ghio, AJ. Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2006;291:L272-L280. (2006) Abstract
Turi, JL; Yang, F; Garrick, MD; Piantadosi, CA; Ghio, AJ. The iron cycle and oxidative stress in the lung. Free Radical Biology and Medicine. 2004;36:850-857. (2004) Abstract
Ghio, AJ; Nozik-Grayck, E; Turi, J; Jaspers, I; Mercatante, DR; Kole, R; Piantadosi, CA. Superoxide-dependent iron uptake: a new role for anion exchange protein 2. American Journal of Respiratory Cell and Molecular Biology. 2003;29:653-660. (2003) Abstract
Turi, JL; Jaspers, I; Dailey, LA; Madden, MC; Brighton, LE; Carter, JD; Nozik-Grayck, E; Piantadosi, CA; Ghio, AJ. Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2002;283:L791-L798. (2002) Abstract