Physicians

Department / Division
Pediatrics / Pediatrics-Critical Care Med

Address
DUMC 3046
Durham, NC 27710

Appointment Telephone
919-681-5560

Office Telephone
919-681-5560

Fax Telephone
919-681-8359

Training

• MD, University of Massachusetts Medical School, 1995

Residency

• Pediatrics, University of Massachusetts Medical Center, 1995-1998

Fellowship

• Pediatric Critical Care, Duke University Medical Center, 1998-2001

Clinical Interests
Pediatric critical care medicine, acute lung injury

Research Interests
    Iron concentrations are elevated in the airways of patients with inflammatory lung diseases such as cystic fibrosis and ARDS.  The presence of iron in the airway catalyzes the production of highly reactive oxygen species (ROS) that cause cellular injury and trigger oxidant-mediated intracellular signaling.  To limit oxidative stress, iron acquisition and its distribution must be tightly regulated.  Airway epithelial cells normally take up iron and sequester it within ferritin to protect the lung’s extracellular milieu; however, many of these mechanisms remain unclear.  The goals of our work are to more clearly define mechanisms of cellular iron transport in airway epithelial cells and to determine the role of disrupted iron homeostasis in the pathogenesis of inflammatory lung disease.

Industry Relationships and Collaborations (What's this?)

This physician has no reported relationships with industry.

Representative Publications
Ozment CP, Turi JL. Iron overload following red blood cell transfusion and its impact on disease severity. Biochim Biophys Acta. 2009 Jul;1790(7):694-701. (2009) Abstract

Turi JL, Piantadosi CA, Stonehuerner JD, Ghio AJ. Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport. Biometals. 2008 May 16. (2008) Abstract

Ghio AJ, Turi JL, Madden MC, Dailey LA, Richards JD, Stonehuerner JG, Morgan DL, Singleton S, Garrick LM, Garrick MD. Lung injury after ozone exposure is iron dependent. Am J Physiol Lung Cell Mol Physiol. 2007 Jan;292(1):L134-43. (2007) Abstract

Ghio AJ, Turi JL, Yang F, Garrick LM, Garrick MD. Iron homeostasis in the lung. Biol Res. 2006;39(1):67-77. (2006) Abstract

Turi JL, Wang X, McKie AT, Nozik-Grayck E, Mamo LB, Crissman K, Piantadosi CA, Ghio AJ. Duodenal cytochrome b: a novel ferrireductase in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L272-80. (2006) Abstract

Turi JL, Yang F, Garrick MD, Piantadosi CA, Ghio AJ. The iron cycle and oxidative stress in the lung. Free Radic Biol Med. 2004 Apr 1;36(7):850-7. (2004) Abstract

Ghio AJ, Nozik-Grayck E, Turi J, Jaspers I, Mercatante DR, Kole R, Piantadosi CA. Superoxide-dependent iron uptake: a new role for anion exchange protein 2. Am J Respir Cell Mol Biol. 2003 Dec;29(6):653-60. (2003) Abstract

Turi JL, Jaspers I, Dailey LA, Madden MC, Brighton LE, Carter JD, Nozik-Grayck E, Piantadosi CA, Ghio AJ. Oxidative stress activates anion exchange protein 2 and AP-1 in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2002 Oct;283(4):L791-8. (2002) Abstract