Division Chief, Pediatric Cardiology
Departments / Divisions
Address
DUMC 3090
Durham, NC 27710
Appointment Telephone
919-668-4000
Office Telephone
919-681-2916
Fax Telephone
919-681-0366
Clinical Interests
Pediatric cardiology, echocardiography, hypertension, hyperlipidemia
Research Interests
1. Pediatric hypertension and hyperlipidemia
2. Clinical trials in children with heart disease
3. Thrombosis in patients with congenital heart disease
4. Enzyme replacement in Pompe disease
5. Infective endocarditis
This faculty member has no reported relationships with industry.
Representative Publications
Baker-Smith, CM; Benjamin, DK; Califf, RM; Murphy, MD; Li, JS; Smith, PB. Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials. Clinical Pharmacology and Therapeutics. 2010;87:668-671.
(2010)
Abstract
Barker, GM; O'Brien, SM; Welke, KF; Jacobs, ML; Jacobs, JP; Benjamin, DK; Peterson, ED; Jaggers, J; Li, JS. Major infection after pediatric cardiac surgery: a risk estimation model. Annals of Thoracic Surgery. 2010;89:843-850.
(2010)
Abstract
Li, JS; Flynn, JT; Portman, R; Davis, I; Ogawa, M; Shi, H; Pressler, ML. The efficacy and safety of the novel aldosterone antagonist eplerenone in children with hypertension: a randomized, double-blind, dose-response study. Journal of Pediatrics. 2010;157:282-287.
(2010)
Abstract
Li, JS; Newburger, JW. Antiplatelet therapy in pediatric cardiovascular patients. Pediatric Cardiology. 2010;31:454-461.
(2010)
Abstract
Benjamin, DK; Smith, PB; Sun, MJ; Murphy, MD; Avant, D; Mathis, L; Rodriguez, W; Califf, RM; Li, JS. Safety and transparency of pediatric drug trials. Archives of Pediatrics and Adolescent Medicine. 2009;163:1080-1086.
(2009)
Abstract
Hsu, DT; Mital, S; Ravishankar, C; Margossian, R; Li, JS; Sleeper, LA; Williams, RV; Levine, JC; McCrindle, BW; Atz, AM; Servedio, D; Mahony, L; Pediatric Heart Network Investigators. Rationale and design of a trial of angiotensin-converting enzyme inhibition in infants with single ventricle. American Heart Journal. 2009;157:37-45.
(2009)
Abstract
Baker-Smith, CM; Benjamin, DK; Grabowski, HG; Reid, ED; Mangum, B; Goldsmith, JV; Murphy, MD; Edwards, R; Eisenstein, EL; Sun, J; Califf, RM; Li, JS. The economic returns of pediatric clinical trials of antihypertensive drugs. American Heart Journal. 2008;156:682-688.
(2008)
Abstract
Benjamin, DK; Smith, PB; Jadhav, P; Gobburu, JV; Murphy, MD; Hasselblad, V; Baker-Smith, C; Califf, RM; Li, JS. Pediatric antihypertensive trial failures: analysis of end points and dose range. Hypertension. 2008;51:834-840.
(2008)
Abstract
Levine, JC; Kishnani, PS; Chen, YT; Herlong, JR; Li, JS. Cardiac remodeling after enzyme replacement therapy with acid alpha-glucosidase for infants with Pompe disease. Pediatric Cardiology. 2008;29:1033-1042.
(2008)
Abstract
Li, JS; Baker-Smith, CM; Smith, PB; Hasselblad, V; Murphy, MD; Califf, RM; Benjamin, DK. Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis. Clinical Pharmacology and Therapeutics. 2008;84:315-319.
(2008)
Abstract
Li, JS; Yow, E; Berezny, KY; Bokesch, PM; Takahashi, M; Graham, TP; Sanders, SP; Sidi, D; Bonnet, D; Ewert, P; Jennings, LK; Michelson, AD; PICOLO Investigators. Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial. Circulation. 2008;117:553-559.
(2008)
Abstract
McDowell, R; Li, JS; Benjamin, DK; Morgan, C; Becker, A; Kishnani, PS; Kanter, RJ. Arrhythmias in patients receiving enzyme replacement therapy for infantile Pompe disease. Genetics in Medicine. 2008;10:758-762.
(2008)
Abstract
Smith, PB; Benjamin, DK; Murphy, MD; Johann-Liang, R; Iyasu, S; Gould, B; Califf, RM; Li, JS; Rodriguez, W. Safety monitoring of drugs receiving pediatric marketing exclusivity. Pediatrics. 2008;122:e628-e633.
(2008)
Abstract
Smith, PB; Li, JS; Murphy, MD; Califf, RM; Benjamin, DK. Safety of placebo controls in pediatric hypertension trials. Hypertension. 2008;51:829-833.
(2008)
Abstract
Li, JS; Eisenstein, EL; Grabowski, HG; Reid, ED; Mangum, B; Schulman, KA; Goldsmith, JV; Murphy, MD; Califf, RM; Benjamin, DK. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA: Journal of the American Medical Association. 2007;297:480-488.
(2007)
Abstract
Li, JS; Yow, E; Berezny, KY; Rhodes, JF; Bokesch, PM; Charpie, JR; Forbus, GA; Mahony, L; Boshkov, L; Lambert, V; Bonnet, D; Michel-Behnke, I; Graham, TP; Takahashi, M; Jaggers, J; Califf, RM; Rakhit, A; Fontecave, S; Sanders, SP. Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference?. Circulation. 2007;116:293-297.
(2007)
Abstract
McCrindle, BW; Li, JS; Minich, LL; Colan, SD; Atz, AM; Takahashi, M; Vetter, VL; Gersony, WM; Mitchell, PD; Newburger, JW; Pediatric Heart Network Investigators. Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements. Circulation. 2007;116:174-179.
(2007)
Abstract
Minich, LL; Sleeper, LA; Atz, AM; McCrindle, BW; Lu, M; Colan, SD; Printz, BF; Klein, GL; Sundel, RP; Takahashi, M; Li, JS; Vetter, VL; Newburger, JW; Pediatric Heart Network Investigators. Delayed diagnosis of Kawasaki disease: what are the risk factors?. Pediatrics. 2007;120:e1434-e1440.
(2007)
Abstract
Newburger, JW; Sleeper, LA; McCrindle, BW; Minich, LL; Gersony, W; Vetter, VL; Atz, AM; Li, JS; Takahashi, M; Baker, AL; Colan, SD; Mitchell, PD; Klein, GL; Sundel, RP; Pediatric Heart Network Investigators. Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease. New England Journal of Medicine. 2007;356:663-675.
(2007)
Abstract
Ansong, AK; Li, JS; Nozik-Grayck, E; Ing, R; Kravitz, RM; Idriss, SF; Kanter, RJ; Rice, H; Chen, YT; Kishnani, PS. Electrocardiographic response to enzyme replacement therapy for Pompe disease. Genetics in Medicine. 2006;8:297-301.
(2006)
Abstract
Benjamin, DK; Smith, PB; Murphy, MD; Roberts, R; Mathis, L; Avant, D; Califf, RM; Li, JS. Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA: Journal of the American Medical Association. 2006;296:1266-1273.
(2006)
Abstract
Cook, AL; Kishnani, PS; Carboni, MP; Kanter, RJ; Chen, YT; Ansong, AK; Kravitz, RM; Rice, H; Li, JS. Ambulatory electrocardiogram analysis in infants treated with recombinant human acid alpha-glucosidase enzyme replacement therapy for Pompe disease. Genetics in Medicine. 2006;8:313-317.
(2006)
Abstract
Li, JS; Jaggers, J; Anderson, PA. The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass. Expert Review of Cardiovascular Therapy. 2006;4:649-654.
(2006)
Abstract
McCrindle, BW; Williams, RV; Mitchell, PD; Hsu, DT; Paridon, SM; Atz, AM; Li, JS; Newburger, JW; Pediatric Heart Network Investigators. Relationship of patient and medical characteristics to health status in children and adolescents after the Fontan procedure. Circulation. 2006;113:1123-1129.
(2006)
Abstract
Menon, S; Berezny, KY; Kilaru, R; Benjamin, DK; Kay, JD; Hazan, L; Portman, R; Hogg, R; Deitchman, D; Califf, RM; Li, JS. Racial differences are seen in blood pressure response to fosinopril in hypertensive children. American Heart Journal. 2006;152:394-399.
(2006)
Abstract
Valente, AM; Jain, R; Scheurer, M; Fowler, VG; Corey, GR; Bengur, AR; Sanders, S; Li, JS. Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia. Pediatrics. 2005;115:e15-e19.
(2005)
Abstract
Li, JS; Berezny, K; Kilaru, R; Hazan, L; Portman, R; Hogg, R; Jenkins, RD; Kanani, P; Cottrill, CM; Mattoo, TK; Zharkova, L; Kozlova, L; Weisman, I; Deitchman, D; Califf, RM. Is the extrapolated adult dose of fosinopril safe and effective in treating hypertensive children?. Hypertension. 2004;44:289-293.
(2004)
Abstract
Li, JS; Sanders, SP; Perry, AE; Stinnett, SS; Jaggers, J; Bokesch, P; Reynolds, L; Nassar, R; Anderson, PA. Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypass. American Heart Journal. 2004;147:173-180.
(2004)
Abstract
Milazzo, AS; Herlong, JR; Li, JS; Sanders, SP; Barrington, M; Bengur, AR. Real-time transmission of pediatric echocardiograms using a single ISDN line. Computers in Biology and Medicine. 2002;32:379-388.
(2002)
Abstract
Pasquali, SK; Sanders, SP; Li, JS. Oral antihypertensive trial design and analysis under the pediatric exclusivity provision. American Heart Journal. 2002;144:608-614.
(2002)
Abstract
Milazzo, AS; Li, JS. Bacterial endocarditis in infants and children. Pediatric Infectious Disease Journal. 2001;20:799-801.
(2001)
Abstract
Li, JS; Sexton, DJ; Mick, N; Nettles, R; Fowler, VG; Ryan, T; Bashore, T; Corey, GR. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clinical Infectious Diseases. 2000;30:633-638.
(2000)
Abstract
