Physicians

Division Chief, Pediatric Cardiology

Departments / Divisions

• Pediatrics / Pediatrics-Cardiology
• Medicine / Medicine - Cardiology

Address
DUMC 3090
Durham, NC 27710

Appointment Telephone
919-668-4000

Office Telephone
919-681-2916

Fax Telephone
919-681-0366

Training

• MD, Duke University School of Medicine, 1987

Residency

• Pediatrics, Children's Hospital of Philadelphia (Pennsylvania), 1987-1989
• Pediatrics, Duke University Medical Center, 1989-1990

Fellowship

• Pediatric Cardiology, Duke University Medical Center, 1990-1993

Clinical Interests
Pediatric cardiology, echocardiography, hypertension, hyperlipidemia

Research Interests
1. Pediatric hypertension and hyperlipidemia
2. Clinical trials in children with heart disease
3. Thrombosis in patients with congenital heart disease
4. Enzyme replacement in Pompe disease
5. Infective endocarditis

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Baker-Smith, CM; Benjamin, DK; Califf, RM; Murphy, MD; Li, JS; Smith, PB. Cough in pediatric patients receiving angiotensin-converting enzyme inhibitor therapy or angiotensin receptor blocker therapy in randomized controlled trials. Clinical Pharmacology and Therapeutics. 2010;87:668-671. (2010) Abstract

Barker, GM; O'Brien, SM; Welke, KF; Jacobs, ML; Jacobs, JP; Benjamin, DK; Peterson, ED; Jaggers, J; Li, JS. Major infection after pediatric cardiac surgery: a risk estimation model. Annals of Thoracic Surgery. 2010;89:843-850. (2010) Abstract

Li, JS; Flynn, JT; Portman, R; Davis, I; Ogawa, M; Shi, H; Pressler, ML. The efficacy and safety of the novel aldosterone antagonist eplerenone in children with hypertension: a randomized, double-blind, dose-response study. Journal of Pediatrics. 2010;157:282-287. (2010) Abstract

Li, JS; Newburger, JW. Antiplatelet therapy in pediatric cardiovascular patients. Pediatric Cardiology. 2010;31:454-461. (2010) Abstract

Benjamin, DK; Smith, PB; Sun, MJ; Murphy, MD; Avant, D; Mathis, L; Rodriguez, W; Califf, RM; Li, JS. Safety and transparency of pediatric drug trials. Archives of Pediatrics and Adolescent Medicine. 2009;163:1080-1086. (2009) Abstract

Hsu, DT; Mital, S; Ravishankar, C; Margossian, R; Li, JS; Sleeper, LA; Williams, RV; Levine, JC; McCrindle, BW; Atz, AM; Servedio, D; Mahony, L; Pediatric Heart Network Investigators. Rationale and design of a trial of angiotensin-converting enzyme inhibition in infants with single ventricle. American Heart Journal. 2009;157:37-45. (2009) Abstract

Baker-Smith, CM; Benjamin, DK; Grabowski, HG; Reid, ED; Mangum, B; Goldsmith, JV; Murphy, MD; Edwards, R; Eisenstein, EL; Sun, J; Califf, RM; Li, JS. The economic returns of pediatric clinical trials of antihypertensive drugs. American Heart Journal. 2008;156:682-688. (2008) Abstract

Benjamin, DK; Smith, PB; Jadhav, P; Gobburu, JV; Murphy, MD; Hasselblad, V; Baker-Smith, C; Califf, RM; Li, JS. Pediatric antihypertensive trial failures: analysis of end points and dose range. Hypertension. 2008;51:834-840. (2008) Abstract

Levine, JC; Kishnani, PS; Chen, YT; Herlong, JR; Li, JS. Cardiac remodeling after enzyme replacement therapy with acid alpha-glucosidase for infants with Pompe disease. Pediatric Cardiology. 2008;29:1033-1042. (2008) Abstract

Li, JS; Baker-Smith, CM; Smith, PB; Hasselblad, V; Murphy, MD; Califf, RM; Benjamin, DK. Racial differences in blood pressure response to angiotensin-converting enzyme inhibitors in children: a meta-analysis. Clinical Pharmacology and Therapeutics. 2008;84:315-319. (2008) Abstract

Li, JS; Yow, E; Berezny, KY; Bokesch, PM; Takahashi, M; Graham, TP; Sanders, SP; Sidi, D; Bonnet, D; Ewert, P; Jennings, LK; Michelson, AD; PICOLO Investigators. Dosing of clopidogrel for platelet inhibition in infants and young children: primary results of the Platelet Inhibition in Children On cLOpidogrel (PICOLO) trial. Circulation. 2008;117:553-559. (2008) Abstract

McDowell, R; Li, JS; Benjamin, DK; Morgan, C; Becker, A; Kishnani, PS; Kanter, RJ. Arrhythmias in patients receiving enzyme replacement therapy for infantile Pompe disease. Genetics in Medicine. 2008;10:758-762. (2008) Abstract

Smith, PB; Benjamin, DK; Murphy, MD; Johann-Liang, R; Iyasu, S; Gould, B; Califf, RM; Li, JS; Rodriguez, W. Safety monitoring of drugs receiving pediatric marketing exclusivity. Pediatrics. 2008;122:e628-e633. (2008) Abstract

Smith, PB; Li, JS; Murphy, MD; Califf, RM; Benjamin, DK. Safety of placebo controls in pediatric hypertension trials. Hypertension. 2008;51:829-833. (2008) Abstract

Li, JS; Eisenstein, EL; Grabowski, HG; Reid, ED; Mangum, B; Schulman, KA; Goldsmith, JV; Murphy, MD; Califf, RM; Benjamin, DK. Economic return of clinical trials performed under the pediatric exclusivity program. JAMA: Journal of the American Medical Association. 2007;297:480-488. (2007) Abstract

Li, JS; Yow, E; Berezny, KY; Rhodes, JF; Bokesch, PM; Charpie, JR; Forbus, GA; Mahony, L; Boshkov, L; Lambert, V; Bonnet, D; Michel-Behnke, I; Graham, TP; Takahashi, M; Jaggers, J; Califf, RM; Rakhit, A; Fontecave, S; Sanders, SP. Clinical outcomes of palliative surgery including a systemic-to-pulmonary artery shunt in infants with cyanotic congenital heart disease: does aspirin make a difference?. Circulation. 2007;116:293-297. (2007) Abstract

McCrindle, BW; Li, JS; Minich, LL; Colan, SD; Atz, AM; Takahashi, M; Vetter, VL; Gersony, WM; Mitchell, PD; Newburger, JW; Pediatric Heart Network Investigators. Coronary artery involvement in children with Kawasaki disease: risk factors from analysis of serial normalized measurements. Circulation. 2007;116:174-179. (2007) Abstract

Minich, LL; Sleeper, LA; Atz, AM; McCrindle, BW; Lu, M; Colan, SD; Printz, BF; Klein, GL; Sundel, RP; Takahashi, M; Li, JS; Vetter, VL; Newburger, JW; Pediatric Heart Network Investigators. Delayed diagnosis of Kawasaki disease: what are the risk factors?. Pediatrics. 2007;120:e1434-e1440. (2007) Abstract

Newburger, JW; Sleeper, LA; McCrindle, BW; Minich, LL; Gersony, W; Vetter, VL; Atz, AM; Li, JS; Takahashi, M; Baker, AL; Colan, SD; Mitchell, PD; Klein, GL; Sundel, RP; Pediatric Heart Network Investigators. Randomized trial of pulsed corticosteroid therapy for primary treatment of Kawasaki disease. New England Journal of Medicine. 2007;356:663-675. (2007) Abstract

Ansong, AK; Li, JS; Nozik-Grayck, E; Ing, R; Kravitz, RM; Idriss, SF; Kanter, RJ; Rice, H; Chen, YT; Kishnani, PS. Electrocardiographic response to enzyme replacement therapy for Pompe disease. Genetics in Medicine. 2006;8:297-301. (2006) Abstract

Benjamin, DK; Smith, PB; Murphy, MD; Roberts, R; Mathis, L; Avant, D; Califf, RM; Li, JS. Peer-reviewed publication of clinical trials completed for pediatric exclusivity. JAMA: Journal of the American Medical Association. 2006;296:1266-1273. (2006) Abstract

Cook, AL; Kishnani, PS; Carboni, MP; Kanter, RJ; Chen, YT; Ansong, AK; Kravitz, RM; Rice, H; Li, JS. Ambulatory electrocardiogram analysis in infants treated with recombinant human acid alpha-glucosidase enzyme replacement therapy for Pompe disease. Genetics in Medicine. 2006;8:313-317. (2006) Abstract

Li, JS; Jaggers, J; Anderson, PA. The use of TP10, soluble complement receptor 1, in cardiopulmonary bypass. Expert Review of Cardiovascular Therapy. 2006;4:649-654. (2006) Abstract

McCrindle, BW; Williams, RV; Mitchell, PD; Hsu, DT; Paridon, SM; Atz, AM; Li, JS; Newburger, JW; Pediatric Heart Network Investigators. Relationship of patient and medical characteristics to health status in children and adolescents after the Fontan procedure. Circulation. 2006;113:1123-1129. (2006) Abstract

Menon, S; Berezny, KY; Kilaru, R; Benjamin, DK; Kay, JD; Hazan, L; Portman, R; Hogg, R; Deitchman, D; Califf, RM; Li, JS. Racial differences are seen in blood pressure response to fosinopril in hypertensive children. American Heart Journal. 2006;152:394-399. (2006) Abstract

Valente, AM; Jain, R; Scheurer, M; Fowler, VG; Corey, GR; Bengur, AR; Sanders, S; Li, JS. Frequency of infective endocarditis among infants and children with Staphylococcus aureus bacteremia. Pediatrics. 2005;115:e15-e19. (2005) Abstract

Li, JS; Berezny, K; Kilaru, R; Hazan, L; Portman, R; Hogg, R; Jenkins, RD; Kanani, P; Cottrill, CM; Mattoo, TK; Zharkova, L; Kozlova, L; Weisman, I; Deitchman, D; Califf, RM. Is the extrapolated adult dose of fosinopril safe and effective in treating hypertensive children?. Hypertension. 2004;44:289-293. (2004) Abstract

Li, JS; Sanders, SP; Perry, AE; Stinnett, SS; Jaggers, J; Bokesch, P; Reynolds, L; Nassar, R; Anderson, PA. Pharmacokinetics and safety of TP10, soluble complement receptor 1, in infants undergoing cardiopulmonary bypass. American Heart Journal. 2004;147:173-180. (2004) Abstract

Milazzo, AS; Herlong, JR; Li, JS; Sanders, SP; Barrington, M; Bengur, AR. Real-time transmission of pediatric echocardiograms using a single ISDN line. Computers in Biology and Medicine. 2002;32:379-388. (2002) Abstract

Pasquali, SK; Sanders, SP; Li, JS. Oral antihypertensive trial design and analysis under the pediatric exclusivity provision. American Heart Journal. 2002;144:608-614. (2002) Abstract

Milazzo, AS; Li, JS. Bacterial endocarditis in infants and children. Pediatric Infectious Disease Journal. 2001;20:799-801. (2001) Abstract

Li, JS; Sexton, DJ; Mick, N; Nettles, R; Fowler, VG; Ryan, T; Bashore, T; Corey, GR. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clinical Infectious Diseases. 2000;30:633-638. (2000) Abstract