Jeffrey R. Petrella, MD
Department / Division
Radiology /
Neuroradiology
Address
DUMC 3808
Durham, NC 27710
Appointment Telephone
919-684-7218
Office Telephone
919-684-7458
Fax Telephone
919-684-7157
- MD, University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School, 1987
- Transitional Internship, St. Vincent's Hospital and Medical Center of New York, 1987-1988
- Radiology, St. Vincent's Hospital and Medical Center of New York, 1988-1992
- Neuroradiology, Hospital of University of Pennsylvania, 1992-1994
- MRI (Research), NIH Imaging Sciences Training Program (Maryland), 1994-1997
Clinical Interests
Functional MRI, presurgical planning, dementia
Research Interests
- Quantitating and modeling physiologic processes in normal and diseased states in the central nervous system through the use of imaging
- Application and development of advanced MR imaging technologies (e.g., diffusion, perfusion and fMRI) as well as advanced image processing and analysis techniques
- Elucidating the functional unpinnings of cognitive impairment in early stage Alzheimer's disease
- Development of functional imaging biomarkers for early diagnosis and monitoring of dementia
- Functional MRI as an aid to preoperative planning in patients with potentially resectable brain lesions
This physician (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
- Janssen AI
- Wilson Elser
Representative Publications
Petrella JR, Prince SE, Krishnan S, Husn H, Kelley L, Doraiswamy PM. Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging. AJNR Am J Neuroradiol. 2009 Feb;30(2):411-6.
(2009)
Abstract
Petrella JR, Mattay VS, Doraiswamy PM. Imaging genetics of brain longevity and mental wellness: the next frontier? Radiology. 2008 Jan;246(1):20-32.
(2008)
Abstract
Prince SE, Woo S, Doraiswamy PM, Petrella JR. Functional MRI in the early diagnosis of Alzheimer's disease: is it time to refocus? Expert Rev Neurother. 2008 Feb;8(2):169-75.
(2008)
Abstract
Petrella JR, Prince SE, Wang L, Hellegers C, Doraiswamy PM. Prognostic value of posteromedial cortex deactivation in mild cognitive impairment. PLoS One. 2007;2(10):e1104.
(2007)
Abstract
Petrella JR, Wang L, Krishnan S, Slavin MJ, Prince SE, Tran TT, Doraiswamy PM. Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging. Radiology. 2007 Oct;245(1):224-35.
(2007)
Abstract
Krishnan S, Slavin MJ, Tran TT, Doraiswamy PM, Petrella JR. Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders. Neuroimage. 2006 Jun;31(2):560-71.
(2006)
Abstract
Petrella JR, Krishnan S, Slavin MJ, Tran TT, Murty L, Doraiswamy PM. Mild cognitive impairment: evaluation with 4-T functional MR imaging. Radiology. 2006 Jul;240(1):177-86.
(2006)
Abstract
Petrella JR, Shah LM, Harris KM, Friedman AH, George TM, Sampson JH, Pekala JS, Voyvodic JT. Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors. Radiology. 2006 Sep;240(3):793-802.
(2006)
Abstract
Sandstrom CK, Krishnan S, Slavin MJ, Tran TT, Doraiswamy PM, Petrella JR. Hippocampal Atrophy Confounds Template-Based Functional MR Imaging Measures of Hippocampal Activation in Patients with Mild Cognitive Impairment. AJNR Am J Neuroradiol. 2006 Sep;27(8):1622-7.
(2006)
Abstract
Krishnan S, Talley BD, Slavin MJ, Doraiswamy PM, Petrella JR. Current status of functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging in Alzheimer's disease diagnosis and research. Neuroimaging Clin N Am. 2005 Nov;15(4):853-68, xi.
(2005)
Abstract
Petrella JR, Townsend BA, Jha AP, Ziajko LA, Slavin MJ, Lustig C, Hart SJ, Doraiswamy PM. Increasing memory load modulates regional brain activity in older adults as measured by fMRI. J Neuropsychiatry Clin Neurosci. 2005;17(1):75-83.
(2005)
Abstract
Sair HI, Doraiswamy PM, Petrella JR. In vivo amyloid imaging in Alzheimer's disease. Neuroradiology. 2004 Feb;46(2):93-104.
(2004)
Abstract
Petrella JR, Coleman RE, Doraiswamy PM. Neuroimaging and early diagnosis of Alzheimer disease: a look to the future. Radiology. 2003 Feb;226(2):315-36.
(2003)
Abstract
Petrella JR, Lustig C, Bucher LA, Jha AP, Doraiswamy PM. Prefrontal activation patterns in subjects at risk for Alzheimer disease. Am J Geriatr Psychiatry. 2002 Jan-Feb;10(1):112-3.
(2002)
Abstract
Petrella JR, Provenzale JM. MR perfusion imaging of the brain: techniques and applications. AJR Am J Roentgenol. 2000 Jul;175(1):207-19.
(2000)
Abstract
Petrella JR, DeCarli C, Dagli M, Grandin CB, Duyn JH, Frank JA, Hoffman EA, Theodore WH. Age-related vasodilatory response to acetazolamide challenge in healthy adults: a dynamic contrast-enhanced MR study. AJNR Am J Neuroradiol. 1998 Jan;19(1):39-44.
(1998)
Abstract
Petrella JR, DeCarli C, Dagli M, Duyn JH, Grandin CB, Frank JA, Hoffman EA, Theodore WH. Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst. AJNR Am J Neuroradiol. 1997 Jun-Jul;18(6):1153-61.
(1997)
Abstract
