Physicians

Department / Division
Radiology / Neuroradiology

Address
DUMC 3808
Durham, NC 27710

Appointment Telephone
919-684-7218

Office Telephone
919-684-7218

Fax Telephone
919-684-7168

Training

• MD, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 1987

Residency

• Transitional Internship, Saint Vincent's Hospital and Medical Center of New York, 1987-1988
• Radiology, Saint Vincent's Hospital and Medical Center of New York, 1988-1992

Fellowship

• Neuroradiology, Hospital of University of Pennsylvania, 1992-1994
• MRI (Research), National Institutes of Health Imaging Sciences Training Program (Maryland), 1994-1997

Clinical Interests
Functional MRI, presurgical planning, dementia

Research Interests
- Quantitating and modeling physiologic processes in normal and diseased states in the central nervous system through the use of imaging
- Application and development of advanced MR imaging technologies (e.g., diffusion, perfusion and fMRI) as well as advanced image processing and analysis techniques
- Elucidating the functional unpinnings of cognitive impairment in early stage Alzheimer's disease
- Development of functional imaging biomarkers for early diagnosis and monitoring of dementia
- Functional MRI as an aid to preoperative planning in patients with potentially resectable brain lesions

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Invivo (Phillips)
• Janssen AI (Johnson & Johnson)
• Piramal Healthcare
• Quintiles

Representative Publications
Petrella, JR; Prince, SE; Krishnan, S; Husn, H; Kelley, L; Doraiswamy, PM. Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging. American Journal of Neuroradiology. 2009;30:411-416. (2009) Abstract

Petrella, JR; Mattay, VS; Doraiswamy, PM. Imaging genetics of brain longevity and mental wellness: the next frontier?. Radiology. 2008;246:20-32. (2008) Abstract

Prince, SE; Woo, S; Doraiswamy, PM; Petrella, JR. Functional MRI in the early diagnosis of Alzheimer's disease: is it time to refocus?. Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders. 2008;8:169-175. (2008) Abstract

Petrella, JR; Prince, SE; Wang, L; Hellegers, C; Doraiswamy, PM. Prognostic value of posteromedial cortex deactivation in mild cognitive impairment. PLoS One. 2007;2:e1104. (2007) Abstract

Petrella, JR; Wang, L; Krishnan, S; Slavin, MJ; Prince, SE; Tran, TT; Doraiswamy, PM. Cortical deactivation in mild cognitive impairment: high-field-strength functional MR imaging. Radiology. 2007;245:224-235. (2007) Abstract

Krishnan, S; Slavin, MJ; Tran, TT; Doraiswamy, PM; Petrella, JR. Accuracy of spatial normalization of the hippocampus: implications for fMRI research in memory disorders. Neuroimage. 2006;31:560-571. (2006) Abstract

Petrella, JR; Krishnan, S; Slavin, MJ; Tran, TT; Murty, L; Doraiswamy, PM. Mild cognitive impairment: evaluation with 4-T functional MR imaging. Radiology. 2006;240:177-186. (2006) Abstract

Petrella, JR; Shah, LM; Harris, KM; Friedman, AH; George, TM; Sampson, JH; Pekala, JS; Voyvodic, JT. Preoperative functional MR imaging localization of language and motor areas: effect on therapeutic decision making in patients with potentially resectable brain tumors. Radiology. 2006;240:793-802. (2006) Abstract

Sandstrom, CK; Krishnan, S; Slavin, MJ; Tran, TT; Doraiswamy, PM; Petrella, JR. Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment. American Journal of Neuroradiology. 2006;27:1622-1627. (2006) Abstract

Krishnan, S; Talley, BD; Slavin, MJ; Doraiswamy, PM; Petrella, JR. Current status of functional MR imaging, perfusion-weighted imaging, and diffusion-tensor imaging in Alzheimer's disease diagnosis and research. Neuroimaging Clinics of North America. 2005;15:853-xi. (2005) Abstract

Petrella, JR; Townsend, BA; Jha, AP; Ziajko, LA; Slavin, MJ; Lustig, C; Hart, SJ; Doraiswamy, PM. Increasing memory load modulates regional brain activity in older adults as measured by fMRI. Journal of Neuropsychiatry and Clinical Neurosciences. 2005;17:75-83. (2005) Abstract

Sair, HI; Doraiswamy, PM; Petrella, JR. In vivo amyloid imaging in Alzheimer's disease. Neuroradiology: a journal devoted to neuroimaging and interventional neuroradiology. 2004;46:93-104. (2004) Abstract

Petrella, JR; Coleman, RE; Doraiswamy, PM. Neuroimaging and early diagnosis of Alzheimer disease: a look to the future. Radiology. 2003;226:315-336. (2003) Abstract

Petrella, JR; Lustig, C; Bucher, LA; Jha, AP; Doraiswamy, PM. Prefrontal activation patterns in subjects at risk for Alzheimer disease. American Journal of Geriatric Psychiatry. 2002;10:112-113. (2002) Abstract

Petrella, JR; Provenzale, JM. MR perfusion imaging of the brain: techniques and applications. American Journal of Roentgenology. 2000;175:207-219. (2000) Abstract

Petrella, JR; DeCarli, C; Dagli, M; Grandin, CB; Duyn, JH; Frank, JA; Hoffman, EA; Theodore, WH. Age-related vasodilatory response to acetazolamide challenge in healthy adults: a dynamic contrast-enhanced MR study. American Journal of Neuroradiology. 1998;19:39-44. (1998) Abstract

Petrella, JR; DeCarli, C; Dagli, M; Duyn, JH; Grandin, CB; Frank, JA; Hoffman, EA; Theodore, WH. Assessment of whole-brain vasodilatory capacity with acetazolamide challenge at 1.5 T using dynamic contrast imaging with frequency-shifted burst. American Journal of Neuroradiology. 1997;18:1153-1161. (1997) Abstract