Department / Division:
Radiology / Neuroradiology

Address:
DUMC 3808
Durham, NC 27710

Appointment Telephone:
919-684-7218

Office Telephone:
919-684-7409

Fax Telephone:
919-684-7138

• MD, Albany Medical College (New York), 1983

• Neurology, UNC Hospitals, 1984-1997
• Radiology, Massachusetts General Hospital, 1987-1991

• Neuroradiology, Massachusetts General Hospital, 1990-1992

Clinical Interests:
MR diffusion and perfusion imaging, tumor imaging, molecular imaging, novel contrast agents

Research Interests:
I have three major research areas:
I. Applications of nanotechnology to treatment of cancer (both CNS and non-CNS) and brain disorders. I have active collaborations with researchers at Duke University Medical Center and Emory University/Georgia Tech employing nanoparticles for cancer diagnosis and therapy. In addition, I have a strong interest in use of nanotechnology for CNS tissue engineering. In parallel, I am actively working with researchers on the use of stem cells for this purpose.
II. Brain tumor imaging in cinical trials and experimental studies with specific focus on:
(A) development of forms of molecular imaging of brain tumors that will allow more specific and sensitive means of understanding tumor physiology,
(B) novel methods of perfusion imaging of brain tumors to understand tumor behavior and response to various therapies, and
(C) development of novel contrast agents.
With regard to molecular imaging of tumors, I am specifically interested in development of non-invasive and minimally invasive devices that can continuously monitor tumor physiological characteristics and response to therapy. This work is done in conjunction with a number of colleagues in Radiation Oncology and Biomedical Engineering and supported by a number of NIH grants as well as the NIH-funded Duke Brain Tumor SPORE (Specialized Program of Research Excellence) and the Duke Breast Tumor SPORE.

III. Diffusion tensor imaging (an MR technique that measures rate and direction of microscopic water motion) to examine white matter pathways in the brain and spinal cord. This technique, which has many research applications that we are bringing into the clinical realm, is very well suited for understanding white matter disorders such as childhood leukodystrophies and multiple sclerosis.
  The research techniques that we are exploring are highly advanced but can be understood and used by someone with little technical knowledge and only a preliminary understanding of computers. Because we use a variety of very "user-friendly" software programs, personnel with little experience with these topics or the techniques can be easily trained to analyze data in a very short time period. On the other hand, our research is also well-suited to someone with advanced computer skills or an interest in biomedical or electrical engineering.

Representative Publications:
Provenzale JM, Peddi S, Kurtzberg J, Poe MD, Mukundan S, Escolar M. Correlation of neurodevelopmental features and MRI findings in infantile Krabbe's disease. AJR Am J Roentgenol. 2009 Jan;192(1):59-65. (2009) Abstract

Crow MJ, Grant G, Provenzale JM, Wax A. Molecular imaging and quantitative measurement of epidermal growth factor receptor expression in live cancer cells using immunolabeled gold nanoparticles. AJR Am J Roentgenol. 2009 Apr;192(4):1021-8. (2009) Abstract

Viola RJ, Provenzale JM, Li F, Li CY, Yuan H, Tashjian J, Dewhirst MW. In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy. AJR Am J Roentgenol. 2008 Dec;191(6):1779-84. (2008) Abstract

Provenzale JM, vanLandingham KE, Lewis DV, Mukundan S Jr, White LE. Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging. Radiology. 2008 Dec;249(3):955-63. (2008) Abstract

Provenzale JM, Wintermark M. Optimization of perfusion imaging for acute cerebral ischemia: review of recent clinical trials and recommendations for future studies. AJR Am J Roentgenol. 2008 Oct;191(4):1263-70. (2008) Abstract

Provenzale JM, Barboriak DP, VanLandingham K, MacFall J, Delong D, Lewis DV. Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial temporal sclerosis. AJR Am J Roentgenol. 2008 Apr;190(4):976-83. (2008) Abstract

Provenzale JM. Imaging of angiogenesis: clinical techniques and novel imaging methods. AJR Am J Roentgenol. 2007 Jan;188(1):11-23. (2007) Abstract

Provenzale JM, Liang L, DeLong D, White LE. Diffusion tensor imaging assessment of brain white matter maturation during the first postnatal year. AJR Am J Roentgenol. 2007 Aug;189(2):476-86. (2007) Abstract

Madden DJ, Spaniol J, Whiting WL, Bucur B, Provenzale JM, Cabeza R, White LE, Huettel SA. Adult age differences in the functional neuroanatomy of visual attention: A combined fMRI and DTI study. Neurobiol Aging. 2007 Mar;28(3):459-76. (2007) Abstract

Beam D, Poe MD, Provenzale JM, Szabolcs P, Martin PL, Prasad V, Parikh S, Driscoll T, Mukundan S, Kurtzberg J, Escolar ML. Outcomes of unrelated umbilical cord blood transplantation for X-linked adrenoleukodystrophy. Biol Blood Marrow Transplant. 2007 Jun;13(6):665-74. (2007) Abstract

Provenzale JM, York G, Moya MG, Parks L, Choma M, Kealey S, Cole P, Serajuddin H. Correlation of relative permeability and relative cerebral blood volume in high-grade cerebral neoplasms. AJR Am J Roentgenol. 2006 Oct;187(4):1036-42. (2006) Abstract

Provenzale JM, Mukundan S, Barboriak DP. Diffusion-weighted and perfusion MR imaging for brain tumor characterization and assessment of treatment response. Radiology. 2006 Jun;239(3):632-49. (2006) Abstract

York G, Barboriak D, Petrella J, DeLong D, Provenzale JM. Association of internal carotid artery injury with carotid canal fractures in patients with head trauma. AJR Am J Roentgenol. 2005 May;184(5):1672-8. (2005) Abstract

Taylor WD, MacFall JR, Payne ME, McQuoid DR, Steffens DC, Provenzale JM, Krishnan RR. Greater MRI lesion volumes in elderly depressed subjects than in control subjects. Psychiatry Res. 2005 May 30;139(1):1-7. (2005) Abstract

Steffens DC, Pieper CF, Bosworth HB, MacFall JR, Provenzale JM, Payne ME, Carroll BJ, George LK, Krishnan KR. Biological and social predictors of long-term geriatric depression outcome. Int Psychogeriatr. 2005 Mar;17(1):41-56. (2005) Abstract

Provenzale JM. Introduction to the AJR Technology Forum: issues, controversies & utility of PET/CT imaging. AJR Am J Roentgenol. 2005 May;184(5 Suppl):Sii. (2005) Abstract

Provenzale JM, Stanley RJ. A systematic guide to reviewing a manuscript. AJR Am J Roentgenol. 2005 Oct;185(4):848-54. (2005) Abstract

Provenzale JM, Mukundan S. Getting small is suddenly very big: review of the proceedings of the third annual meeting of the Society for Molecular Imaging. AJR Am J Roentgenol. 2005 Jun;184(6):1736-9. (2005) Abstract

Provenzale JM, Mukundan S, Dewhirst M. The role of blood-brain barrier permeability in brain tumor imaging and therapeutics. AJR Am J Roentgenol. 2005 Sep;185(3):763-7. (2005) Abstract

McGraw P, Liang L, Escolar M, Mukundan S, Kurtzberg J, Provenzale JM. Krabbe disease treated with hematopoietic stem cell transplantation: serial assessment of anisotropy measurements--initial experience. Radiology. 2005 Jul;236(1):221-30. (2005) Abstract

Lai KC, Provenzale JM, Delong D, Mukundan S Jr. Assessing patient utilities for varying degrees of low back pain. Acad Radiol. 2005 Apr;12(4):467-74. (2005) Abstract

Kealey SM, Kim Y, Whiting WL, Madden DJ, Provenzale JM. Determination of multiple sclerosis plaque size with diffusion-tensor MR Imaging: comparison study with healthy volunteers. Radiology. 2005 Aug;236(2):615-20. (2005) Abstract

Taylor WD, MacFall JR, Payne ME, McQuoid DR, Provenzale JM, Steffens DC, Krishnan KR. Late-life depression and microstructural abnormalities in dorsolateral prefrontal cortex white matter. Am J Psychiatry. 2004 Jul;161(7):1293-6. (2004) Abstract

Provenzale JM, McGraw P, Mhatre P, Guo AC, Delong D. Peritumoral brain regions in gliomas and meningiomas: investigation with isotropic diffusion-weighted MR imaging and diffusion-tensor MR imaging. Radiology. 2004 Aug;232(2):451-60. (2004) Abstract

Kealey SM, Kim Y, Provenzale JM. Redefinition of multiple sclerosis plaque size using diffusion tensor MRI. AJR Am J Roentgenol. 2004 Aug;183(2):497-503. (2004) Abstract

Holmes TM, Petrella JR, Provenzale JM. Distinction between cerebral abscesses and high-grade neoplasms by dynamic susceptibility contrast perfusion MRI. AJR Am J Roentgenol. 2004 Nov;183(5):1247-52. (2004) Abstract

4. Provenzale JM, Heinz ER, Ortel TL, Macik CG, Alberts MJ. Neuroradiologic findings in non-SLE patients with antiphospholipid antibodies. Radiology 1994;192:531-537. (1994)