Physicians

Department / Division
Pediatrics / Pediatrics-Neonatology

Address
DUMC 2739
Durham, NC 27710

Office Telephone
919-681-6024

Fax Telephone
919-681-6065

Training

• MD, University of Florida College of Medicine, 2002

Residency

• Pediatrics, Shands Teaching Hospital, University of Florida, 2002-2005

Fellowship

• Neonatology, Shands Teaching Hospital, University of Florida, 2005-2008

Clinical Interests
Care of premature and critically ill infants, neonatal sepsis, immunology and immunomodulation, physician teaching and development

Research Interests
Neonatal immunity
Neonatal Sepsis
Immunomodulation

Industry Relationships and Collaborations (What's this?)

This physician has no reported relationships with industry.

Representative Publications
Cuenca AG, Wynn JL, Kelly-Scumpia KM, Scumpia PO, Vila L, Delano MJ, Mathews CE, Wallet SM, Reeves WH, Behrns KE, Nacionales DC, Efron PA, Kunkel SL, Moldawer LL. Critical Role for CXC Ligand 10/CXC Receptor 3 Signaling in the Murine Neonatal Response to Sepsis. Infect Immun. 2011 Jul;79(7):2746-54. (2011) Abstract

Kelly-Scumpia KM, Scumpia PO, Weinstein JS, Delano MJ, Cuenca AG, Nacionales DC, Wynn JL, Lee PY, Kumagai Y, Efron PA, Akira S, Wasserfall C, Atkinson MA, Moldawer LL. B cells enhance early innate immune responses during bacterial sepsis. J Exp Med. 2011 Jul 11. (2011) Abstract

Wynn JL, Cvijanovich NZ, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Shanley TP, Bigham MT, Banschbach S, Beckman E, Wong HR. The Influence of Developmental Age on the Early Transcriptomic Response of Children with Septic Shock. Mol Med. 2011 Jul 5. (2011) Abstract

Cornell TT, Wynn J, Shanley TP, Wheeler DS, Wong HR. Mechanisms and regulation of the gene-expression response to sepsis. Pediatrics. 2010 Jun;125(6):1248-58. (2010) Abstract

Kelly-Scumpia KM, Scumpia PO, Delano MJ, Weinstein JS, Cuenca AG, Wynn JL, Moldawer LL. Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10. J Exp Med. 2010 Feb 15;207(2):319-26. (2010) Abstract

Wynn J, Cornell TT, Wong HR, Shanley TP, Wheeler DS. The host response to sepsis and developmental impact. Pediatrics. 2010 May;125(5):1031-41. (2010) Abstract

Wynn JL, Levy O. Role of innate host defenses in susceptibility to early-onset neonatal sepsis. Clin Perinatol. 2010 Jun;37(2):307-37. (2010) Abstract

Wynn JL, Seed PC, Cotten CM. Does IVIg administration yield improved immune function in very premature neonates? J Perinatol. 2010 Jan 7. (2010) Abstract

Wynn JL, Wong HR. Pathophysiology and treatment of septic shock in neonates. Clin Perinatol. 2010 Jun;37(2):439-79. (2010) Abstract

Kataria J, Li N, Wynn JL, Neu J. Probiotic microbes: do they need to be alive to be beneficial? Nutr Rev. 2009 Sep;67(9):546-50. (2009) Abstract

Wynn JL, Neu J, Moldawer LL, Levy O. Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis. J Perinatol. 2009 Feb;29(2):79-88. (2009) Abstract

Wynn JL, Saxonhouse MA, Sleasman JW: Immunodeficiency Diseases of the Neonate, In Neonatal Hematology 2nd Edition, De Alarcon, Werner & Christensen: Editors. Cambridge University In Press. (2009)

Wynn, JL, Burchfield DJ, Saxonhouse MA. CRP in neonatal sepsis: Is it a helpful marker? Contemporary Pediatrics, Oct 2009 26(10): 52-57. (2009)

Wynn, JL. Premature newborn care.  BMJ-Point of Care. e-manuscript available online, March 2009. (2009)

Wynn JL, Scumpia PO, Winfield RD, Delano MJ, Kelly-Scumpia K, Barker T, Ungaro R, Levy O, Moldawer LL. Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood. 2008 Sep 1;112(5):1750-8. (2008) Abstract

Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med. 2007 Jun 11;204(6):1463-74. (2007) Abstract

Scumpia PO, Delano MJ, Kelly-Scumpia KM, Weinstein JS, Wynn JL, Winfield RD, Xia C, Chung CS, Ayala A, Atkinson MA, Reeves WH, Clare-Salzler MJ, Moldawer LL. Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood. 2007 Nov 15;110(10):3673-81. (2007) Abstract

Wynn JL, Scumpia PO, Delano MJ, O'Malley KA, Ungaro R, Abouhamze A, Moldawer KL. Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock. 2007 Dec;28(6):675-683. (2007) Abstract

Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA, Reeves WH, Salzler MJ, Moldawer LL. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol. 2006 Dec 1;177(11):7943-9. (2006) Abstract