Department / Division:
Pediatrics / Neonatology

Address:
DUMC 2739
Durham, NC 27710

Office Telephone:
919-681-6024

Fax Telephone:
919-681-6065

• MD, University of Florida College of Medicine, 2002

• Pediatrics, Shands Teaching Hospital, University of Florida, 2002-2005

• Neonatology, Shands Teaching Hospital, University of Florida, 2005-2008

Clinical Interests:
Care of premature and critically ill infants, neonatal sepsis, immunology and immunomodulation, physician teaching and development

Research Interests:
Neonatal immunity, immunomodulation

Representative Publications:
Wynn JL, Wong HR.  Pathophysiology and Treatment of Septic Shock in Neonates. Clinics in Perinatology. In press. (2010)

Wynn JL, Levy O. Role of Innate Host Defenses in Susceptibility to Early Onset Neonatal Sepsis. Clinics in Perinatology. In press. (2010)

Wynn, JL. Premature newborn care.  BMJ-Point of Care. e-manuscript available online, March 2009. (2009)

Wynn, JL, Burchfield DJ, Saxonhouse MA. CRP in neonatal sepsis: Is it a helpful marker? Contemporary Pediatrics, Oct 2009 26(10): 52-57. (2009)

Wynn JL, Saxonhouse MA, Sleasman JW: Immunodeficiency Diseases of the Neonate, In Neonatal Hematology 2nd Edition, De Alarcon, Werner & Christensen: Editors. Cambridge University In Press. (2009)

Wynn JL, Neu J, Moldawer LL, Levy O. Potential of immunomodulatory agents for prevention and treatment of neonatal sepsis. J Perinatol. 2009 Feb;29(2):79-88. (2009) Abstract

Kataria J, Li N, Wynn JL, Neu J. Probiotic microbes: do they need to be alive to be beneficial? Nutr Rev. 2009 Sep;67(9):546-50. (2009) Abstract

Wynn JL, Scumpia PO, Winfield RD, Delano MJ, Kelly-Scumpia K, Barker T, Ungaro R, Levy O, Moldawer LL. Defective innate immunity predisposes murine neonates to poor sepsis outcome but is reversed by TLR agonists. Blood. 2008 Sep 1;112(5):1750-8. (2008) Abstract

Wynn JL, Scumpia PO, Delano MJ, O'Malley KA, Ungaro R, Abouhamze A, Moldawer KL. Increased mortality and altered immunity in neonatal sepsis produced by generalized peritonitis. Shock. 2007 Dec;28(6):675-683. (2007) Abstract

Scumpia PO, Delano MJ, Kelly-Scumpia KM, Weinstein JS, Wynn JL, Winfield RD, Xia C, Chung CS, Ayala A, Atkinson MA, Reeves WH, Clare-Salzler MJ, Moldawer LL. Treatment with GITR agonistic antibody corrects adaptive immune dysfunction in sepsis. Blood. 2007 Nov 15;110(10):3673-81. (2007) Abstract

Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, O'Malley KA, Wynn JL, Antonenko S, Al-Quran SZ, Swan R, Chung CS, Atkinson MA, Ramphal R, Gabrilovich DI, Reeves WH, Ayala A, Phillips J, Laface D, Heyworth PG, Clare-Salzler M, Moldawer LL. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med. 2007 Jun 11;204(6):1463-74. (2007) Abstract

Scumpia PO, Delano MJ, Kelly KM, O'Malley KA, Efron PA, McAuliffe PF, Brusko T, Ungaro R, Barker T, Wynn JL, Atkinson MA, Reeves WH, Salzler MJ, Moldawer LL. Increased natural CD4+CD25+ regulatory T cells and their suppressor activity do not contribute to mortality in murine polymicrobial sepsis. J Immunol. 2006 Dec 1;177(11):7943-9. (2006) Abstract