Department / Division:
Pediatrics / Pulmonary and Sleep Medicine

Address:
DUMC 2994
Durham, NC 27710

Appointment Telephone:
919-681-3364

Office Telephone:
919-684-2356

Fax Telephone:
919-684-2292

• MD, University of Mississippi School of Medicine, 1981

• Pediatrics, University Medical Center (Mississippi), 1981-1984

• Pediatric Pulmonology Fellowship, Duke University Medical Center, 1987-1990

Clinical Interests:
Pediatric lung disease, bronchoscopy, pulmonary-function testing (particularly in infants), bronchopulmonary dysplasia, cystic fibrosis, asthma, reflux-medicated lung disease, recurrent respiratory infections, apnea

Research Interests:
The focus of my research has been in bringing new therapies from the research laboratory to the patient.
Cystic Fibrosis Clinical Trials
Cystic Fibrosis Epidemiologic Study
During my participation in various trials these past years, I have found myself with several questions:  1) Is our current understanding of the natural history of cystic fibrosis correct and, therefore, 2) are our current endpoints appropriate for scientific investigation of new therapies? 3) What regimen of therapy will be most likely to be accepted by patients and therefore efficacious because of patient compliance?  In an attempt to help answer to these questions, I am participating in the largest epidemiology study of cystic fibrosis ever undertaken.  It is hoped
that through this study, clinical parameters will be identified that can become treatment markers suitable for future research endeavors.  In addition, I have been involved in the early planning studies of a large-scale study of compliance issues in the adolescent with cystic fibrosis. Information gained from these studies will provide groundwork for studies in cystic fibrosis at both a national level as well as for smaller projects at a local level.

Infantile onset Pompe disease.

Representative Publications:
Amalfitano A, Bengur AR, Morse RP, Majure JM, Case LE, Veerling DL, Mackey J, Kishnani P, Smith W, McVie-Wylie A, Sullivan J, Hoganson GE, Phillips JA III, Schaefer GB, Charrow J, Ware RE, Bossen EH, Chen YT. Recombinant human acid alpha glucosidase enzyme therapy for intantile glycogen storage disease type II: Results of phase I/II clinical trial. Genetics in Medicine. 3(2):132-138, 2001 (2001)

Marshall BC, Majure M, Samuelson WM, Murphy T, Henshaw CM, Rubin BK, Kennedy TP. Phase II study of aerosolized tyloxapol in CF subjects with mild to moderate pulmonary disease. Pediatric Pulmonology. 2000; Suppl. 20:249. (Poster Presentation, North American Cystic Fibrosis Conference, November, 2000) (2000)

Britto MT, Garrett JM, Konrad TR, Majure JM, Leigh MW. Comparison of Physical Activity in Aolescents with Cystic Fibrosis vs. Age-Matched Controls. Pediatric Pulmonology. 30(2):86-91, 2000. (2000)

Donnelly LF, MacFall JR, McAdams HP, Majure JM, Smith J, Frush DP, Bogonad P, Charles HC, Ravin CE. Cystic Fibrosis: combined hyperpolarized 3H3-enhanced and conventional proton MR imaging in the lung--preliminary observartions. Radiology. 212(3):885-9, 1999. (1999)

Britto MT, Garrett JM, Dugliss MAJ, Daeschner, Jr. CW, Johnson CA, Leigh MW, Majure JM, Schultz WH, Conrad TR. Preventive services received by adolescents with cystic fibrosis and sickle cell disease. Archives of Pediatrics and Adolescent Medicine. 153(1):27-32, 1999. (1999)

Britto MT, Garrett JM, Dugliss MAJ, Daeschner, Jr., CW, Johnson CA, Leigh MW, Majure JM, Schultz WH, Konrad TR. Risky behavior in teens with cystic fibrosis or sickle cell disease: A multicenter study. Pediatrics. 1998; 101:250-256. (1998)

Markert ML, Majure M, Harville TO, Hulka G, Oldham K. Severe laryngomalacia and bronchomalacia in DiGeorge Syndrome. Pediatric Pulmonology. 1997; 24:364-369. (1997)

Majure JM. Clinical consultation: How to assess airway hyperesponsiveness in young childlren. J Respiratory Dis. 1997; 18(3):230. (1997)

Majure JM. Clinical consultation: How to assess airway hyperresponsiveness in young children. J Respiratory Dis 1997; 18(3):230. (1997)

Knight J, Rourk JH Jr, Majure JM. The use of the modified Tuttle test (TART) and the prrd pH probe study in the diagnosis of gastroesophageal reflux (GER) in children with cystic fibrosis (CF). Pediatric Pulmonology. 1997; Suppl. 14:311. (Poster presentation, North American Cystic Fibrosis Conference, October, 1997) (1997)

Knight J, Majure JM, Rourk MH Jr. The use of the modified Tuttle test in the diagnosis of gastroesophageal reflux in infancy and childhood. Am J Respir Crit Care Med. 1997; 155(4, Part 2):A712. (Poster presentation, ATS International Conference, May, 1997) (1997)

Goldstein RF, Majure M, Lohmeyer MB. Occult reactive airway disease after hospital discharge in infants treated with ECMO. Pediatric Research. 1996; 39(4)Part 2:265A. (Poster presentation, APS-SPR, May, 1996) (1996)

Majure M, Carden J, Browning I. Estimation of RV/TLC in CF at Initial Presentation Indicates Early Hyperinflation. Pediatric Pulmonology. 1995; Supplement 12:253. (Poster presentation, North American Cystic Fibrosis Conference, October, 1995) (1995)

Sockrider MM, Majure M, Oliver D, Nissenfeld M. Chronic therapy in mild to moderate cystic fibrosis: patient, caregiver, and clinician perspectives on adherence. Submitted.

Murphy LMB, Thompson RJ, Morris MA, Majure M. Psychological Adjustment of Adolescents with a chronic illness: the role of illness type, maternal adjustment, and stress modifying processes. Submitted

Britto MT, Garrett JM, Dugliss MAJ, Daeschner, Jr. HR, Johnson CA, Leigh MW, Majure M, Mikow VA, Schultz WH, Konrad TR. Differences in risk taking behavior between healthy and chronically ill teens: a multicenter study. Submitted.