Physicians

Division Chief, Pediatric Critical Care Medicine

Department / Division
Pediatrics / Pediatrics-Critical Care Med

Address
DUMC 3046
Durham, NC 27710

Office Telephone
919-681-5872

Fax Telephone
919-681-8357

Training

• MD, Yale University School of Medicine (Connecticut), 1989

Residency

• Pediatrics, Duke University Medical Center, 1989-1993

Fellowship

• Pediatric Critical Care, Duke University Medical Center, 1993-1996

Other Training

• Fellow, American College of Critical Care Medicine
• Fellowship of the American Association of Respiratory Care

Clinical Interests
Pediatric critical care medicine, acute lung injury, high-frequency ventilation, cardiopulmonary interactions, cardiopulmonary resuscitation, ECMO, congenital heart disease, mechanical ventilation

Research Interests
Extracorporeal membrane oxygenation (ECMO) / Ambulatory ECMO
Mechanical ventilation
Respiratory mechanics monitoring / Airway graphics
Capnography: time-based and volumetric
Cardiorespiratory interactions
Acute lung injury and acute respiratory distress syndrome (ARDS)
High-frequency ventilation
Right ventricular injury and inotrope administration
Noninvasive ventilation

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Hill Rom
• Philips Medical Systems
• Teleflex Inc.

Representative Publications
Lee, JH; Rehder, KJ; Williford, L; Cheifetz, IM; Turner, DA. Use of high flow nasal cannula in critically ill infants, children, and adults: a critical review of the literature. Intensive Care Medicine. 2013;39:247-257. (2013) Abstract

Peterson-Carmichael, SL; Cheifetz, IM. The chronically critically ill patient: pediatric considerations. Respiratory Care: a monthly science journal. 2012;57:993-1002. (2012) Abstract

Rehder, KJ; Turner, DA; Bonadonna, D; Walczak, RJ; Cheifetz, IM. State of the art: strategies for extracorporeal membrane oxygenation in respiratory failure. Expert Review of Respiratory Medicine. 2012;6:513-521. (2012) Abstract

Rehder, KJ; Turner, DA; Bonadonna, D; Walczak, RJ; Rudder, RJ; Cheifetz, IM. Technological advances in extracorporeal membrane oxygenation for respiratory failure. Expert Review of Respiratory Medicine. 2012;6:377-384. (2012) Abstract

Rehder, KJ; Turner, DA; Hartwig, MG; Williford, WL; Bonadonna, D; Walczak, RJ; Davis, RD; Zaas, D; Cheifetz, IM. Active rehabilitation during ECMO as a bridge to lung transplantation. Respiratory Care: a monthly science journal. 2012; (2012) Abstract

Thomas, NJ; Guardia, CG; Moya, FR; Cheifetz, IM; Markovitz, B; Cruces, P; Barton, P; Segal, R; Simmons, P; Randolph, AG; PALISI Network. A pilot, randomized, controlled clinical trial of lucinactant, a peptide-containing synthetic surfactant, in infants with acute hypoxemic respiratory failure. Pediatric Critical Care Medicine. 2012;13:646-653. (2012) Abstract

Turner, DA; Adams, DF; Gentile, MA; Williford, L; Quick, GA; Smith, PB; Cheifetz, IM. Bias flow does not affect ventilation during high-frequency oscillatory ventilation in a pediatric animal model of acute lung injury. Pediatric Critical Care Medicine. 2012;13:e108-e112. (2012) Abstract

Turner, DA; Rehder, KJ; Cheifetz, IM. Nontraditional modes of mechanical ventilation: progress or distraction?. Expert Review of Respiratory Medicine. 2012;6:277-284. (2012) Abstract

Watt, KM; Benjamin, DK; Cheifetz, IM; Moorthy, G; Wade, KC; Smith, PB; Brouwer, KL; Capparelli, EV; Cohen-Wolkowiez, M. Pharmacokinetics and safety of fluconazole in young infants supported with extracorporeal membrane oxygenation. Pediatric Infectious Disease Journal. 2012;31:1042-1047. (2012) Abstract

Watt, KM; Walgos, J; Cheifetz, IM; Turner, DA. Dexmedetomidine for transport of a spontaneously breathing combative child. Pediatrics. 2012;130:e690-e694. (2012) Abstract

Cheifetz, IM. Management of acute lung injury: sharing data between adults and children. Respiratory Care: a monthly science journal. 2011;56:1258-1268. (2011) Abstract

Cheifetz, IM. Pediatric acute respiratory distress syndrome. Respiratory Care: a monthly science journal. 2011;56:1589-1599. (2011) Abstract

Cohen-Wolkowiez, M; Benjamin, DK; Piper, L; Cheifetz, IM; Moran, C; Liu, P; Aram, J; Kashuba, AD; Capparelli, E; Walsh, TJ; Hope, WW; Smith, PB. Safety and pharmacokinetics of multiple-dose anidulafungin in infants and neonates. Clinical Pharmacology and Therapeutics. 2011;89:702-707. (2011) Abstract

DiBlasi, RM; Cheifetz, IM. Neonatal and pediatric respiratory care: what does the future hold?. Respiratory Care: a monthly science journal. 2011;56:1466-1480. (2011) Abstract

Gandhi, NN; Hartman, ME; Williford, WL; Peters, MA; Cheifetz, IM; Turner, DA. Successful use of extracorporeal membrane oxygenation for pH1N1-induced refractory hypoxemia in a child with hypoplastic left heart syndrome. Pediatric Critical Care Medicine. 2011;12:e398-e401. (2011) Abstract

Goodman, DM; Winkler, MK; Fiser, RT; Abd-Allah, S; Mathur, M; Rivero, N; Weiss, IK; Peterson, B; Cornfield, DN; Mink, R; Nozik Grayck, E; McCabe, ME; Schuette, J; Nares, MA; Totapally, B; Petrillo-Albarano, T; Wolfson, RK; Moreland, JG; Potter, KE; Fackler, J; Garber, N; Burns, JP; Shanley, TP; Lieh-Lai, MW; Steiner, M; Tieves, KS; Goldsmith, M; Asuncion, A; Ross, SL; Howell, JD; Biagas, K; Ognibene, K; Joshi, P; Rubenstein, JS; Kocis, KC; Cheifetz, IM; Turner, DA; Doughty, L; Hall, MW; Mason, K; Penfil, S; Morrison, W; Hoehn, KS; Watson, RS; Garcia, RL; Storgion, SA; Fleming, GM; Castillo, L; Tcharmtchi, MH; Taylor, RP; Ul Haque, I; Crain, N; Baden, HP; Lee, KJ. The Accreditation Council for Graduate Medical Education proposed work hour regulations. Pediatric Critical Care Medicine. 2011;12:120-121. (2011) Abstract

Hornik, CP; Hartman, ME; Markert, ML; Lodge, AJ; Cheifetz, IM; Turner, DA. Successful extracorporeal membrane oxygenation for respiratory failure in an infant with DiGeorge anomaly, following thymus transplantation. Respiratory Care: a monthly science journal. 2011;56:866-870. (2011) Abstract

Piper, L; Smith, PB; Hornik, CP; Cheifetz, IM; Barrett, JS; Moorthy, G; Hope, WW; Wade, KC; Cohen-Wolkowiez, M; Benjamin, DK. Fluconazole loading dose pharmacokinetics and safety in infants. Pediatric Infectious Disease Journal. 2011;30:375-378. (2011) Abstract

Rehder, KJ; Turner, DA; Cheifetz, IM. Use of extracorporeal life support in adults with severe acute respiratory failure. Expert Review of Respiratory Medicine. 2011;5:627-633. (2011) Abstract

Turner, DA; Cheifetz, IM. Antibiotics in the pediatric intensive care unit: have we finally figured out that less is more?. Pediatric Critical Care Medicine. 2011;12:355-356. (2011) Abstract

Turner, DA; Cheifetz, IM. Pediatric acute respiratory failure: areas of debate in the pediatric critical care setting. Expert Review of Respiratory Medicine. 2011;5:65-73. (2011) Abstract

Turner, DA; Cheifetz, IM; Rehder, KJ; Williford, WL; Bonadonna, D; Banuelos, SJ; Peterson-Carmichael, S; Lin, SS; Davis, RD; Zaas, D. Active rehabilitation and physical therapy during extracorporeal membrane oxygenation while awaiting lung transplantation: a practical approach. Critical Care Medicine. 2011;39:2593-2598. (2011) Abstract

Turner, DA; Rehder, KJ; Peterson-Carmichael, SL; Ozment, CP; Al-Hegelan, MS; Williford, WL; Peters, MA; Noble, PW; Cheifetz, IM. Extracorporeal membrane oxygenation for severe refractory respiratory failure secondary to 2009 H1N1 influenza A. Respiratory Care: a monthly science journal. 2011;56:941-946. (2011) Abstract

Turner, DA; Williford, WL; Peters, MA; Thalman, JJ; Shearer, IR; Walczak, RJ; Griffis, M; Olson, SA; Sowers, KW; Govert, JA; Macintyre, NR; Cheifetz, IM. Development of a collaborative program to provide extracorporeal membrane oxygenation for adults with refractory hypoxemia within the framework of a pandemic. Pediatric Critical Care Medicine. 2011;12:426-430. (2011) Abstract

Abdelsalam, M; Cheifetz, IM. Goal-directed therapy for severely hypoxic patients with acute respiratory distress syndrome: permissive hypoxemia. Respiratory Care: a monthly science journal. 2010;55:1483-1490. (2010) Abstract

Frazier, MD; Cheifetz, IM. The role of heliox in paediatric respiratory disease. Paediatric Respiratory Reviews. 2010;11:46-53. (2010) Abstract

McSwain, SD; Hamel, DS; Smith, PB; Gentile, MA; Srinivasan, S; Meliones, JN; Cheifetz, IM. End-tidal and arterial carbon dioxide measurements correlate across all levels of physiologic dead space. Respiratory Care: a monthly science journal. 2010;55:288-293. (2010) Abstract

Norfolk, SG; Hollingsworth, CL; Wolfe, CR; Govert, JA; Que, LG; Cheifetz, IM; Hollingsworth, JW. Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009. Critical Care Medicine. 2010;38:2103-2107. (2010) Abstract

Nishisaki, A; Hales, R; Biagas, K; Cheifetz, I; Corriveau, C; Garber, N; Hunt, E; Jarrah, R; McCloskey, J; Morrison, W; Nelson, K; Niles, D; Smith, S; Thomas, S; Tuttle, S; Helfaer, M; Nadkarni, V. A multi-institutional high-fidelity simulation "boot camp" orientation and training program for first year pediatric critical care fellows. Pediatric Critical Care Medicine. 2009;10:157-162. (2009) Abstract

Wratney, AT; Benjamin, DK; Slonim, AD; He, J; Hamel, DS; Cheifetz, IM. The endotracheal tube air leak test does not predict extubation outcome in critically ill pediatric patients. Pediatric Critical Care Medicine. 2008;9:490-496. (2008) Abstract

Bass, AL; Gentile, MA; Heinz, JP; Craig, DM; Hamel, DS; Cheifetz, IM. Setting positive end-expiratory pressure during jet ventilation to replicate the mean airway pressure of oscillatory ventilation. Respiratory Care: a monthly science journal. 2007;52:50-55. (2007) Abstract

Cheifetz, IM; MacIntyre, NR. Respiratory controversies in the critical care setting. Conference summary. Respiratory Care: a monthly science journal. 2007;52:636-644. (2007) Abstract

Cheifetz, IM; MacIntyre, NR. Respiratory controversies in the critical care setting. Part I. Respiratory Care: a monthly science journal. 2007;52:406-407. (2007) Abstract

Cheifetz, IM; Myers, TR. Respiratory therapies in the critical care setting. Should every mechanically ventilated patient be monitored with capnography from intubation to extubation?. Respiratory Care: a monthly science journal. 2007;52:423-438. (2007) Abstract

Hurford, WE; Cheifetz, IM. Respiratory controversies in the critical care setting. Should heliox be used for mechanically ventilated patients?. Respiratory Care: a monthly science journal. 2007;52:582-591. (2007) Abstract

Alexander, PJ; Lawson, DS; Cornell, J; Craig, DM; Cheifetz, IM. Insensible water loss from the medtronic minimax oxygenator: an In Vitro study. ASAIO Journal. 2006;52:206-210. (2006) Abstract

Cheifetz, I. Intraoral treatment of Eagle's syndrome. Journal of Oral and Maxillofacial Surgery. 2006;64:749. (2006) Abstract

Cheifetz, IM; Hamel, DS. Is permissive hypoxemia a beneficial strategy for pediatric acute lung injury?. Respiratory Care Clinics of North America. 2006;12:359-vi. (2006) Abstract

Hamel, DS; Cheifetz, IM. Do all mechanically ventilated pediatric patients require continuous capnography?. Respiratory Care Clinics of North America. 2006;12:501-513. (2006) Abstract

Wratney, AT; Cheifetz, IM. Extubation criteria in infants and children. Respiratory Care Clinics of North America. 2006;12:469-481. (2006) Abstract

Gupta, VK; Cheifetz, IM. Heliox administration in the pediatric intensive care unit: an evidence-based review. Pediatric Critical Care Medicine. 2005;6:204-211. (2005) Abstract

Hamel, DS; Katz, AL; Craig, DM; Davies, JD; Cheifetz, IM. Carbon dioxide elimination and gas displacement vary with piston position during high-frequency oscillatory ventilation. Respiratory Care: a monthly science journal. 2005;50:361-366. (2005) Abstract

Lawson, DS; Ing, R; Cheifetz, IM; Walczak, R; Craig, D; Schulman, S; Kern, F; Shearer, IR; Lodge, A; Jaggers, J. Hemolytic characteristics of three commercially available centrifugal blood pumps. Pediatric Critical Care Medicine. 2005;6:573-577. (2005) Abstract

Oden, J; Cheifetz, IM. Neonatal thyrotoxicosis and persistent pulmonary hypertension necessitating extracorporeal life support. Pediatrics. 2005;115:e105-e108. (2005) Abstract

Randolph, AG; Forbes, PW; Gedeit, RG; Arnold, JH; Wetzel, RC; Luckett, PM; O'Neil, ME; Venkataraman, ST; Meert, KL; Cheifetz, IM; Cox, PN; Hanson, JH; Pediatric Acute Lung Injury & Sepsis Investigators (PALISI) Network. Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. Pediatric Critical Care Medicine. 2005;6:642-647. (2005) Abstract

Gentile, MA; Cheifetz, IM. Optimal positive end-expiratory pressure: The search for the Holy Grail continues. Critical Care Medicine. 2004;32:2553-2554. (2004) Abstract

Gupta, VK; Grayck, EN; Cheifetz, IM. Heliox administration during high-frequency jet ventilation augments carbon dioxide clearance. Respiratory Care: a monthly science journal. 2004;49:1038-1044. (2004) Abstract

Hubble, CL; Cheifetz, IM; Craig, DM; Quick, G; Meliones, JN; Clark, RH. Inhaled nitric oxide results in deteriorating hemodynamics when administered during cardiopulmonary bypass in neonatal swine. Pediatric Critical Care Medicine. 2004;5:157-162. (2004) Abstract

Turi, JL; Cheifetz, IM. Does improved oxygenation really imply increased benefit?. Critical Care Medicine. 2004;32:1089-1091. (2004) Abstract

Venkataraman, S; Randolph, A; Hanson, J; Forbes, P; Cheifetz, I; Gedeit, R; Luckett, P. All roses are flowers, but not all flowers are roses. American Journal of Respiratory and Critical Care Medicine. 2004;169:969. (2004) Abstract

Wratney, AT; Gentile, MA; Hamel, DS; Cheifetz, IM. Successful treatment of acute chest syndrome with high-frequency oscillatory ventilation in pediatric patients. Respiratory Care: a monthly science journal. 2004;49:263-269. (2004) Abstract

Cheifetz, IM. Invasive and noninvasive pediatric mechanical ventilation. Respiratory Care: a monthly science journal. 2003;48:442-453. (2003) Abstract

Hagen, SA; Craig, DM; Martin, PL; Plumer, DD; Gentile, MA; Schulman, SR; Cheifetz, IM. Mechanically ventilated pediatric stem cell transplant recipients: effect of cord blood transplant and organ dysfunction on outcome. Pediatric Critical Care Medicine. 2003;4:206-213. (2003) Abstract

Katz, AL; Gentile, MA; Craig, DM; Quick, G; Cheifetz, IM. Heliox does not affect gas exchange during high-frequency oscillatory ventilation if tidal volume is held constant. Critical Care Medicine. 2003;31:2006-2009. (2003) Abstract

Randolph, AG; Meert, KL; O'Neil, ME; Hanson, JH; Luckett, PM; Arnold, JH; Gedeit, RG; Cox, PN; Roberts, JS; Venkataraman, ST; Forbes, PW; Cheifetz, IM; Pediatric Acute Lung Injury and Sepsis Investigators Network. The feasibility of conducting clinical trials in infants and children with acute respiratory failure. American Journal of Respiratory and Critical Care Medicine. 2003;167:1334-1340. (2003) Abstract

Erb, TO; Craig, DM; Gaskin, PM; Cheifetz, IM; Resai Bengur, A; Sanders, SP. Preload recruitable stroke work relationship in the right ventricle: simultaneous assessment using conductance catheter and sonomicrometry. Critical Care Medicine. 2002;30:2535-2541. (2002) Abstract

Randolph, AG; Wypij, D; Venkataraman, ST; Hanson, JH; Gedeit, RG; Meert, KL; Luckett, PM; Forbes, P; Lilley, M; Thompson, J; Cheifetz, IM; Hibberd, P; Wetzel, R; Cox, PN; Arnold, JH; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA: Journal of the American Medical Association. 2002;288:2561-2568. (2002) Abstract

Katz, A; Gentile, MA; Craig, DM; Quick, G; Meliones, JN; Cheifetz, IM. Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injury. American Journal of Respiratory and Critical Care Medicine. 2001;164:260-264. (2001) Abstract

Moya, MP; Gow, AJ; McMahon, TJ; Toone, EJ; Cheifetz, IM; Goldberg, RN; Stamler, JS. S-nitrosothiol repletion by an inhaled gas regulates pulmonary function. Proceedings of the National Academy of Sciences of USA. 2001;98:5792-5797. (2001) Abstract

Williams, EA; Welty, SE; Geske, RS; Hubble, CL; Craig, DM; Quick, G; Meliones, JN; Cheifetz, IM. Liquid lung ventilation reduces neutrophil sequestration in a neonatal swine model of cardiopulmonary bypass. Critical Care Medicine. 2001;29:789-795. (2001) Abstract

Arnold, JH; Anas, NG; Luckett, P; Cheifetz, IM; Reyes, G; Newth, CJ; Kocis, KC; Heidemann, SM; Hanson, JH; Brogan, TV; Bohn, DJ. High-frequency oscillatory ventilation in pediatric respiratory failure: a multicenter experience. Critical Care Medicine. 2000;28:3913-3919. (2000) Abstract

Cannon, ML; Cornell, J; Tripp-Hamel, DS; Gentile, MA; Hubble, CL; Meliones, JN; Cheifetz, IM. Tidal volumes for ventilated infants should be determined with a pneumotachometer placed at the endotracheal tube. American Journal of Respiratory and Critical Care Medicine. 2000;162:2109-2112. (2000) Abstract

Cheifetz, IM. Inhaled nitric oxide: plenty of data, no consensus. Critical Care Medicine. 2000;28:902-903. (2000) Abstract

Cheifetz, IM; Meliones, JN. Hemodynamic effects of high-frequency oscillatory ventilation: a little volume goes a long way. Critical Care Medicine. 2000;28:282-284. (2000) Abstract

Hubble, CL; Gentile, MA; Tripp, DS; Craig, DM; Meliones, JN; Cheifetz, IM. Deadspace to tidal volume ratio predicts successful extubation in infants and children. Critical Care Medicine. 2000;28:2034-2040. (2000) Abstract

Klonin, H; Bowman, B; Peters, M; Raffeeq, P; Durward, A; Bohn, DJ; Meliones, JN; Cheifetz, IM. Negative pressure ventilation via chest cuirass to decrease ventilator-associated complications in infants with acute respiratory failure: a case series. Respiratory Care: a monthly science journal. 2000;45:486-490. (2000) Abstract

McGovern, JJ; Cheifetz, IM; Craig, DM; Bengur, AR; Quick, G; Ungerleider, RM; Meliones, JN. Right ventricular injury in young swine: effects of catecholamines on right ventricular function and pulmonary vascular mechanics. Pediatric Research. 2000;48:763-769. (2000) Abstract

Cannon, ML; Cheifetz, IM; Craig, DM; Hubble, CL; Quick, G; Ungerleider, RM; Smith, PK; Meliones, JN. Optimizing liquid ventilation as a lung protection strategy for neonatal cardiopulmonary bypass: full functional residual capacity dosing is more effective than half functional residual capacity dosing. Critical Care Medicine. 1999;27:1140-1146. (1999) Abstract

Chai, PJ; Williamson, JA; Lodge, AJ; Daggett, CW; Scarborough, JE; Meliones, JN; Cheifetz, IM; Jaggers, JJ; Ungerleider, RM. Effects of ischemia on pulmonary dysfunction after cardiopulmonary bypass. Annals of Thoracic Surgery. 1999;67:731-735. (1999) Abstract

Cheifetz, IM; Cannon, ML; Craig, DM; Quick, G; Kern, FH; Smith, PK; Ungerleider, RM; Meliones, JN. Liquid ventilation improves pulmonary function and cardiac output in a neonatal swine model of cardiopulmonary bypass. Journal of Thoracic and Cardiovascular Surgery. 1998;115:528-535. (1998) Abstract

Cheifetz, IM; Craig, DM; Quick, G; McGovern, JJ; Cannon, ML; Ungerleider, RM; Smith, PK; Meliones, JN. Increasing tidal volumes and pulmonary overdistention adversely affect pulmonary vascular mechanics and cardiac output in a pediatric swine model. Critical Care Medicine. 1998;26:710-716. (1998) Abstract

Meliones, JN; Cheifetz, IM. Treatments for pulmonary artery hypertension: show me the outcome!. Critical Care Medicine. 1998;26:1308-1310. (1998) Abstract

Cheifetz, IM; Kern, FH; Schulman, SR; Greeley, WJ; Ungerleider, RM; Meliones, JN. Serum lactates correlate with mortality after operations for complex congenital heart disease. Annals of Thoracic Surgery. 1997;64:735-738. (1997) Abstract

Hillman, ND; Cheifetz, IM; Craig, DM; Smith, PK; Ungerleider, RM; Meliones, JN. Inhaled nitric oxide, right ventricular efficiency, and pulmonary vascular mechanics: selective vasodilation of small pulmonary vessels during hypoxic pulmonary vasoconstriction. Journal of Thoracic and Cardiovascular Surgery. 1997;113:1006-1013. (1997) Abstract

Cheifetz, IM; Craig, DM; Kern, FH; Black, DR; Hillman, ND; Greeley, WJ; Ungerleider, RM; Smith, PK; Meliones, JN. Nitric oxide improves transpulmonary vascular mechanics but does not change intrinsic right ventricular contractility in an acute respiratory distress syndrome model with permissive hypercapnia. Critical Care Medicine. 1996;24:1554-1561. (1996) Abstract

Trant, CA; Casey, JR; Hansell, D; Cheifetz, I; Meliones, JN; Ungerleider, RM; Browning, I; Greeley, WJ. Successful use of extracorporeal membrane oxygenation in the treatment of acute chest syndrome in a child with severe sickle cell anemia. ASAIO Journal. 1996;42:236-239. (1996) Abstract

Hillman, ND; Meliones, JN; Black, DR; Craig, DM; Cheifetz, IM; Smith, PK. In acute lung injury, inhaled nitric oxide improves ventilation-perfusion matching, pulmonary vascular mechanics, and transpulmonary vascular efficiency. Journal of Thoracic and Cardiovascular Surgery. 1995;110:593-599. (1995) Abstract