Physicians

Departments / Divisions

• Medicine / Medicine - Cardiology
• Neurobiology
• Pharmacology & Cancer Biology

Address
DUMC 103030
Durham, NC 27710

Appointment Telephone
919-681-5816

Office Telephone
919-684-1284

Fax Telephone
919-613-5145

Training

• MD, Johns Hopkins University School of Medicine (Maryland), 1993

Residency

• Internal Medicine, Stanford University Hospital (California), 1995

Fellowship

• Cardiovascular Disease, Stanford University Hospital (California), 1999

Other Training

• PhD, Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University (Maryland), 1993

Clinical Interests
General cardiology, inherited cardiovascular diseases and arrhythmias

Research Interests
Our research focuses on how intracellular Ca²⁺, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca²⁺ influx through voltage-gated Ca²⁺ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca²⁺ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Industry Relationships and Collaborations (What's this?)

This physician has no reported relationships with industry.

Representative Publications
Sun AY, Koontz JI, Shah SH, Piccini JP, Nilsson KR Jr, Craig D, Haynes C, Gregory SG, Hranitzky PM, Pitt GS. The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction. Circ Cardiovasc Genet. 2011 Apr;4(2):163-8. (2011) Abstract

Wang C, Hennessey JA, Kirkton RD, Wang C, Graham V, Puranam RS, Rosenberg PB, Bursac N, Pitt GS. Fibroblast Growth Factor Homologous Factor 13 Regulates Na+ Channels and Conduction Velocity in Murine Hearts. Circ Res. 2011 Aug 4. (2011) Abstract

Wang C, Wang C, Hoch EG, Pitt GS. Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels. J Biol Chem. 2011 Jul 8;286(27):24253-63. (2011) Abstract

Miloushev, V. Z., Levine, J. A., Arbing, M. A., Hunt, J. F., Pitt, G. S., Palmer, A. G. III. Solution Structure of the NaV1.2 C-terminal EF-hand Domain J. Biol. Chem. 284, 6446-6454 (2009) (2009) Abstract

Shah SH, Pitt GS. Genetics of cardiac repolarization. Nat Genet. 2009 Apr;41(4):388-9. (2009) Abstract

Thomsen MB, Wang C, Özgen N, Wang H-G, Rosen MR and Pitt GS. The Accessory Subunit KChIP2 Modulates the Cardiac L-Type Calcium Current. Circ Res 104, 1382-1389 (2009). (2009) Abstract

Wang C, Wang HG, Xie H, Pitt GS. Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini. J Neurosci. 2008 Feb 20;28(8):1865-70. (2008) Abstract

Pitt B, Pitt GS. Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death. Circulation. 2007 Jun 12;115(23):2976-82; discussion 2982. (2007) Abstract

Pitt GS. Calmodulin and CaMKII as molecular switches for cardiac ion channels. Cardiovasc Res. 2007 Mar 1;73(4):641-7. (2007) Abstract

Wang HG, George MS, Kim J, Wang C, Pitt GS. Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons. J Neurosci. 2007 Aug 22;27(34):9086-93. (2007) Abstract

George MS, Pitt GS. The real estate of cardiac signaling: location, location, location. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7535-6. (2006) Abstract

Ghosh S, Nunziato DA, Pitt GS. KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin. Circ Res. 2006 Apr 28;98(8):1048-54. (2006) Abstract

Pitt GS, Dun W, Boyden PA. Remodeled cardiac calcium channels. J Mol Cell Cardiol. 2006 Sep;41(3):373-88. (2006) Abstract

Pitt GS, Pitt B. Aldosterone, ion channels, and sudden death: another piece of the circle? Am J Physiol Heart Circ Physiol. 2006 Jun;290(6):H2176-7. (2006) Abstract

Seu L, Pitt GS. Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases. J Gen Physiol. 2006 Nov;128(5):605-13. (2006) Abstract

Hudmon A, Schulman H, Kim J, Maltez JM, Tsien RW, Pitt GS. CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. J Cell Biol. 2005 Nov 7;171(3):537-47. (2005) Abstract

Maltez JM, Nunziato DA, Kim J, Pitt GS. Essential Ca(V)beta modulatory properties are AID-independent. Nat Struct Mol Biol. 2005 Apr;12(4):372-7. (2005) Abstract

Kim J, Ghosh S, Liu H, Tateyama M, Kass RS, Pitt GS. Calmodulin mediates Ca2+ sensitivity of sodium channels. J Biol Chem. 2004 Oct 22;279(43):45004-12. (2004) Abstract

Kim J, Ghosh S, Nunziato DA, Pitt GS. Identification of the components controlling inactivation of voltage-gated Ca2+ channels. Neuron. 2004 Mar 4;41(5):745-54. (2004) Abstract

McGee AW, Nunziato DA, Maltez JM, Prehoda KE, Pitt GS, Bredt DS. Calcium channel function regulated by the SH3-GK module in beta subunits. Neuron. 2004 Apr 8;42(1):89-99. (2004) Abstract