Physicians

Departments / Divisions

• Medicine / Medicine - Cardiology
• Neurobiology
• Pharmacology & Cancer Biology

Address
DUMC 103030
Durham, NC 27710

Appointment Telephone
919-681-5816

Office Telephone
919-684-1284

Fax Telephone
919-613-5145

Training

• MD, Johns Hopkins University School of Medicine (Maryland), 1993

Residency

• Internal Medicine, Stanford University Hospital (California), 1995

Fellowship

• Cardiovascular Disease, Stanford University Hospital (California), 1999

Other Training

• PhD, Biochemistry, Cellular, and Molecular Biology, Johns Hopkins University (Maryland), 1993

Clinical Interests
General cardiology, inherited cardiovascular diseases, arrhythmias

Research Interests
Our research focuses on how intracellular Ca²⁺, the ultimate signal of membrane excitability, regulates membrane excitability and the consequent function of excitable cells. We have discovered and described multiple mechanisms that control Ca²⁺ influx through voltage-gated Ca²⁺ channels and feedback mechanisms by which internal calcium regulates other channels that influence Ca²⁺ channel function. The work has entailed structure-function analyses of ion channels and their regulatory subunits and studies of mutations that lead to inherited channelopathies such as cardiac arrhythmias and epilepsy.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Daubert, JP; Pitt, GS. Can polymorphisms predict response to antiarrhythmic drugs in atrial fibrillation?. Journal of the American College of Cardiology. 2012;60:546-547. (2012) Abstract

Stephens, SB; Schisler, JC; Hohmeier, HE; An, J; Sun, AY; Pitt, GS; Newgard, CB. A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet ?-cell survival and function. Cell Metabolism. 2012;16:33-43. (2012) Abstract

Wang, C; Chung, BC; Yan, H; Lee, SY; Pitt, GS. Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. Structure. 2012;20:1167-1176. (2012) Abstract

Zhong, L; Bellemer, A; Yan, H; Ken, H; Jessica, R; Hwang, RY; Pitt, GS; Tracey, WD. Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. Cell Reports. 2012;1:43-55. (2012) Abstract

Sun, AY; Koontz, JI; Shah, SH; Piccini, JP; Nilsson, KR; Craig, D; Haynes, C; Gregory, SG; Hranitzky, PM; Pitt, GS. The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction. Circulation: Cardiovascular Genetics. 2011;4:163-168. (2011) Abstract

Wang, C; Hennessey, JA; Kirkton, RD; Wang, C; Graham, V; Puranam, RS; Rosenberg, PB; Bursac, N; Pitt, GS. Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. Circulation Research. 2011;109:775-782. (2011) Abstract

Wang, C; Wang, C; Hoch, EG; Pitt, GS. Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels. Journal of Biological Chemistry. 2011;286:24253-24263. (2011) Abstract

Miloushev, VZ; Levine, JA; Arbing, MA; Hunt, JF; Pitt, GS; Palmer, AG. Solution structure of the NaV1.2 C-terminal EF-hand domain. Journal of Biological Chemistry. 2009;284:6446-6454. (2009) Abstract

Shah, SH; Pitt, GS. Genetics of cardiac repolarization. Nature Genetics. 2009;41:388-389. (2009) Abstract

Thomsen, MB; Wang, C; Ozgen, N; Wang, HG; Rosen, MR; Pitt, GS. Accessory subunit KChIP2 modulates the cardiac L-type calcium current. Circulation Research. 2009;104:1382-1389. (2009) Abstract

Wang, C; Wang, HG; Xie, H; Pitt, GS. Ca2+/CaM controls Ca2+-dependent inactivation of NMDA receptors by dimerizing the NR1 C termini. The Journal of Neuroscience. 2008;28:1865-1870. (2008) Abstract

Pitt, B; Pitt, GS. Added benefit of mineralocorticoid receptor blockade in the primary prevention of sudden cardiac death. Circulation. 2007;115:2976-2982. (2007) Abstract

Pitt, GS. Calmodulin and CaMKII as molecular switches for cardiac ion channels. Cardiovascular Research. 2007;73:641-647. (2007) Abstract

Wang, HG; George, MS; Kim, J; Wang, C; Pitt, GS. Ca2+/calmodulin regulates trafficking of Ca(V)1.2 Ca2+ channels in cultured hippocampal neurons. The Journal of Neuroscience. 2007;27:9086-9093. (2007) Abstract

George, MS; Pitt, GS. The real estate of cardiac signaling: location, location, location. Proceedings of the National Academy of Sciences of USA. 2006;103:7535-7536. (2006) Abstract

Ghosh, S; Nunziato, DA; Pitt, GS. KCNQ1 assembly and function is blocked by long-QT syndrome mutations that disrupt interaction with calmodulin. Circulation Research. 2006;98:1048-1054. (2006) Abstract

Pitt, GS; Dun, W; Boyden, PA. Remodeled cardiac calcium channels. Journal of Molecular and Cellular Cardiology. 2006;41:373-388. (2006) Abstract

Pitt, GS; Pitt, B. Aldosterone, ion channels, and sudden death: another piece of the circle?. American Journal of Physiology: Heart and Circulatory Physiology. 2006;290:H2176-H2177. (2006) Abstract

Seu, L; Pitt, GS. Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases. Journal of General Physiology. 2006;128:605-613. (2006) Abstract

Hudmon, A; Schulman, H; Kim, J; Maltez, JM; Tsien, RW; Pitt, GS. CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. The Journal of Cell Biology. 2005;171:537-547. (2005) Abstract

Maltez, JM; Nunziato, DA; Kim, J; Pitt, GS. Essential Ca(V)beta modulatory properties are AID-independent. Nature Structural and Molecular Biology. 2005;12:372-377. (2005) Abstract

Kim, J; Ghosh, S; Liu, H; Tateyama, M; Kass, RS; Pitt, GS. Calmodulin mediates Ca2+ sensitivity of sodium channels. Journal of Biological Chemistry. 2004;279:45004-45012. (2004) Abstract

Kim, J; Ghosh, S; Nunziato, DA; Pitt, GS. Identification of the components controlling inactivation of voltage-gated Ca2+ channels. Neuron. 2004;41:745-754. (2004) Abstract

McGee, AW; Nunziato, DA; Maltez, JM; Prehoda, KE; Pitt, GS; Bredt, DS. Calcium channel function regulated by the SH3-GK module in beta subunits. Neuron. 2004;42:89-99. (2004) Abstract