Physicians

Department / Division
Anesthesiology / Anesthesiology-GVTU Division

Address
DUMC 3094
Durham, NC 27710

Office Telephone
919-681-5534

Fax Telephone
919-681-7893

Training

• MD, Temple University School of Medicine (Pennsylvania), 1993

Residency

• Anesthesiology, Duke University Medical Center, 1994-1997

Fellowship

• Critical Care Medicine, Duke University Medical Center, 1997-1998

Other Training

• MHSc, Duke University School of Medicine, 2004

Clinical Interests
Vascular high-risk anesthesia, liver transplant anesthesia, critical-care medicine

Research Interests
Research efforts are focused primarily in the area of functional genomics. Work has centered on investigating genetic polymorphisms in the surgical intensive care population that would predispose one to the development of the sepsis syndrome. As an extension of this work, there is ongoing investigation working to identify genetically susceptible populations at risk for developing various types of perioperative organ dysfunction. Parallel studies involve identification of a panel of biomarkers that would enable early diagnosis and intervention for those patients, both surgical and non-surgical that develop the sepsis syndrome. There is also active investigation in the human pharmacology laboratory in the department of anesthesiology involving the phase 1 testing of novel pharmaceutical agents in healthy volunteers.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Moretti, EW; Newman, MF; Muhlbaier, LH; Whellan, D; Petersen, RP; Rossignol, D; McCants, CB; Phillips-Bute, B; Bennett-Guerrero, E. Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery. Archives of Surgery. 2006;141:637-641. (2006) Abstract

Cortinez, LI; Somma, J; Robertson, KM; Keifer, JC; Wright, DR; Hsu, YW; MacLeod, DB; Moretti, EW. Changes in hematocrit based on incremental blood sampling: mathematical models perform poorly. Canadian Journal of Anaesthesia. 2005;52:374-378. (2005) Abstract

MacLeod, DB; Cortinez, LI; Keifer, JC; Cameron, D; Wright, DR; White, WD; Moretti, EW; Radulescu, LR; Somma, J. The desaturation response time of finger pulse oximeters during mild hypothermia. Anaesthesia. 2005;60:65-71. (2005) Abstract

Moretti, EW; Morris, RW; Podgoreanu, M; Schwinn, DA; Newman, MF; Bennett, E; Moulin, VG; Mba, UU; Laskowitz, DT; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. APOE polymorphism is associated with risk of severe sepsis in surgical patients. Critical Care Medicine. 2005;33:2521-2526. (2005) Abstract

Moretti, EW; Ofstead, CL; Kristy, RM; Wetzler, HP. Impact of central venous catheter type and methods on catheter-related colonization and bacteraemia. Journal of Hospital Infection. 2005;61:139-145. (2005) Abstract