Department / Division
Anesthesiology / Anesthesiology-GVTU Division
Durham, NC 27710
Vascular high-risk anesthesia; liver transplant anesthesia; critical-care medicine
Research efforts are focused primarily in the area of functional genomics. Work has centered on investigating genetic polymorphisms in the surgical intensive care population that would predispose one to the development of the sepsis syndrome. As an extension of this work, there is ongoing investigation working to identify genetically susceptible populations at risk for developing various types of perioperative organ dysfunction. Parallel studies involve identification of a panel of biomarkers that would enable early diagnosis and intervention for those patients, both surgical and non-surgical that develop the sepsis syndrome. There is also active investigation in the human pharmacology laboratory in the department of anesthesiology involving the phase 1 testing of novel pharmaceutical agents in healthy volunteers.
This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.
Moretti, EW; Newman, MF; Muhlbaier, LH; Whellan, D; Petersen, RP; Rossignol, D; McCants, CB; Phillips-Bute, B; Bennett-Guerrero, E. Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery. Archives of Surgery. 2006;141:637-641. (2006) Abstract
Cortinez, LI; Somma, J; Robertson, KM; Keifer, JC; Wright, DR; Hsu, YW; MacLeod, DB; Moretti, EW. Changes in hematocrit based on incremental blood sampling: mathematical models perform poorly. Canadian Journal of Anaesthesia. 2005;52:374-378. (2005) Abstract
MacLeod, DB; Cortinez, LI; Keifer, JC; Cameron, D; Wright, DR; White, WD; Moretti, EW; Radulescu, LR; Somma, J. The desaturation response time of finger pulse oximeters during mild hypothermia. Anaesthesia. 2005;60:65-71. (2005) Abstract
Moretti, EW; Morris, RW; Podgoreanu, M; Schwinn, DA; Newman, MF; Bennett, E; Moulin, VG; Mba, UU; Laskowitz, DT; Perioperative Genetics and Safety Outcomes Study (PEGASUS) Investigative Team. APOE polymorphism is associated with risk of severe sepsis in surgical patients. Critical Care Medicine. 2005;33:2521-2526. (2005) Abstract
Moretti, EW; Ofstead, CL; Kristy, RM; Wetzler, HP. Impact of central venous catheter type and methods on catheter-related colonization and bacteraemia. Journal of Hospital Infection. 2005;61:139-145. (2005) Abstract