Department / Division:
Anesthesiology / Anesthesiology

Address:
DUMC 3094
Durham, NC 27710

Office Telephone:
919-681-5534

Fax Telephone:
919-681-7893

• MD, Temple University School of Medicine (Pennsylvania), 1993

• Internal Medicine, Lehigh Valley Hospital (Pennsylvania), 1993-1994
• Anesthesiology, Duke University Medical Center, 1994-1997

• Critical Care Medicine, Duke University Medical Center, 1997-1998

• MHSc, Duke University School of Medicine, 2004

Clinical Interests:
Vascular high-risk anesthesia, liver transplant anesthesia, critical care medicine

Research Interests:
Research efforts are focused primarily in the area of functional genomics. Work has centered on investigating genetic polymorphisms in the surgical intensive care population that would predispose one to the development of the sepsis syndrome.  As an extension of this work, there is ongoing investigation working to identify genetically susceptible populations at risk for developing various types of perioperative organ dysfunction. Parallel studies involve identification of a panel of biomarkers that would enable early diagnosis and intervention for those patients, both surgical and non-surgical that develop the sepsis syndrome. There is also active investigation in the human pharmacology laboratory in the department of anesthesiology involving the phase 1 testing of novel pharmaceutical agents in healthy volunteers.

Representative Publications:
MacLeod DB, Moretti EW, Keifer JC, Gan TJ. Pharmacodynamic response to multiple doses of fentanyl delivered by inhaled thermal aerosol route.  ASA Annual Meeting, San Francisco, CA, October 15, 2007.  Anesthesiology 2007;107:A1242 (2007)

Knudsen NW, Moretti EW, Andolsek KM, Clay AS.  Reducing BSIs: A Quality Improvement Collaboration Between an Academic Medical Center and GME Office.  POSTER session, ASA Annual Meeting, San Francisco, CA, October 16, 2007.  Anesthesiology 2007;107:A1802 (2007)

Hodgins L, Shang A, Moretti EW, Setty H. A Novel Method for Detecting Low Agent Levels in Vaporizers.  ASA Annual Meeting, San Francisco, CA, October 16, 2007.  Anesthesiology 2007;107:A1717 (2007)

Moretti EW, Funk D. Perioperative Medicine: Managing for Outcome. In: Newman MF, Fleisher LA, Fink MP (Eds). Endocrine and Electrolyte Problems. Philadelphia, Saunders; 2007. p 40. (2007)

Moretti EW, Ashraf SH, Olufolabi AJ, Shultz JR, Gan TJ, Young CC.  Opioid Related Side Effects are Common a Week After Elective Total Abdominal Hysterectomy.  POSTER session, ASA Annual Meeting, San Francisco, CA, October 16, 2007.  Anesthesiology 2007;107:A1776 (2007)

Moretti EW, Newman MF, Muhlbaier LH, Whellan D, Petersen RP, Rossignol D, McCants CB Jr, Phillips-Bute B, Bennett-Guerrero E. Effects of decreased preoperative endotoxin core antibody levels on long-term mortality after coronary artery bypass graft surgery.  Arch Surg.  2006 Jul;141(7):637-41; discussion 642. (2006) Abstract

Welsby IJ, Podgoreanu MV, Phillips-Bute B, White WD, Nielsen DM, Mathew JP, Smith PK, Newman MF, Schwinn DA, Stafford-Smith M, for the PEGASUS Investigators. Genetic basis for bleeding after cardiac surgery – A preliminary report. J Thrombosis & Haemostasis 2005;3:1206-1213 (2005)

Stafford-Smith M, Podgoreanu M, Swaminathan M, Phillips-Bute B, Mathew JP, Hauser EH, Winn MP, Milano C, Nielsen DM, Smith M, Morris R, Newman MF, Schwinn DA, for the PEGASUS Investigators. Association of genetic polymorphisms with risk of renal injury after coronary bypass graft surgery. Am J Kidney Dis 2005; 45:519-530 (2005)

Schlosser R, Moretti EW. Anesthesiology: Pearls of Wisdom. In: Robertson KM, Lubarsky DA editors. Genitourinary and Renal Surgery. 2nd ed. Lincoln, NE: Boston Medical Publishing Corporation; 2005. p. 127-136. (2005)

MacLeod DB, Cortinez LI, Keifer JC, Cameron D, Wright DR, White WD, Moretti EW, Radulescu LR, Somma J. The desaturation response time of finger pulse oximeters during mild hypothermia.  Anaesthesia.  2005 Jan;60(1):65-71. (2005) Abstract

Grocott HP, White WD, Morris RW, Podgoreanu MV, Mathew JP, Schwinn DA, Newman MF, for the PEGASUS Investigators. Genetic polymorphisms and the risk of stroke after cardiac surgery. Stroke 2005;369:1854-8 (2005)

Cortinez LI, Somma J, Robertson KM, Keifer JC, Wright DR, Hsu YW, MacLeod DB, Moretti EW. Changes in hematocrit based on incremental blood sampling: mathematical models perform poorly.  Can J Anaesth.  2005 Apr;52(4):374-8. (2005) Abstract

Moretti EW, Ofstead CL, Kristy RM, Wetzler HP. Impact of central venous catheter type and methods on catheter-related colonization and bacteraemia.  J Hosp Infect.  2005 Oct;61(2):139-45. (2005) Abstract

Moretti EW, Morris RW, Podgoreanu M, Schwinn DA, Newman MF, Bennett E, Moulin VG, Mba UU, Laskowitz DT. APOE polymorphism is associated with risk of severe sepsis in surgical patients.  Crit Care Med.  2005 Nov;33(11):2521-6. (2005) Abstract

Moretti EW, Morris RW, Podgoreanu M, Schwinn DA, Newman MF, Bennett E, Moulin VG, Mba UU, Laskowitz DT.  PEGASUS Investigators. APOE polymorphism is associated with risk of severe sepsis in surgical patients. Crit Care Med 2005;33(11):2521-26 (2005)

Moretti EW. Anesthesiology: Pearls of Wisdom. In: Robertson KM, Lubarsky DA editors. Genitourinary and Renal Surgery. 1st ed. Lincoln, NE: Boston Medical Publishing Corporation; 2001. p. 125-132 (2001)

Moretti EW. Handbook of Surgical Intensive Care. In: Clay BM, Milano CA, editors. Anesthesia and Analgesia. 5th ed. St. Louis, MO: Mosby International Ltd; 2000. p. 415-432. (2000)