New Eye Injections Can Combat Macular Degeneration (WRAL-TV, March 22, 2013)
Department / Division
Ophthalmology / Retinal Ophthalmology
Durham, NC 27710
Diagnosis and treatment of macular diseases, especially age-related macular degeneration (AMD), diabetic retinopathy, retinal vascular diseases
Eleonora (Nora) Lad, MD, PhD is a clinician scientist and retinal ophthalmologist with the primary goal of developing novel strategies for early diagnosis and treatment of age-related macular degeneration (AMD).
Dr. Lad specializes in the diagnosis and treatment of macular diseases, such as AMD, diabetic retinopathy, and retinal vascular diseases. She is involved in clinical trials and innovative therapies for the treatment of macular diseases. Dr. Lad is committed to providing the highest level of evidence-based patient care.
Dr. Lad’s career goal is to translate her doctoral training in neuroscience into developing innovative diagnostic and therapeutic approaches for AMD. Her research interests are the following:
1) investigating the role of aberrant protein aggregates in the pathogenesis of AMD and developing treatments to combat abnormal protein aggregation in this aging disease
2) visual function testing in dry AMD with the goal of establishing functional endpoints for future clinical studies in early AMD
3) health services research studies performed in collaboration with the Duke Clinical Research Institute (DCRI). These studies explore the history of treatments for macular disases such as anti-VEGF drugs in patients with neovascular AMD and examine patient factors and outcomes associated with treatment of AMD with anti-VEGF therapy
4) elucidating the use of novel retinal imaging biomarkers for early diagnosis of aging diseases (AMD and neurodegenerative diseases such as Alzheimer’s disease). On these studies, she is collaborating with an interdisciplinary team of investigators from Ophthalmology, Geriatrics, Biomedical Engineering, Neurology and Alzheimer’s Disease Research Center.
Dr. Lad was awarded the Clinical Scientist Development Award from the National Eye Institute and is the recipient of the Heed Foundation award. She is a member of the American Academy of Ophthalmology, Association for Research in Vision and Ophthalmology, Society of Heed Fellows, Society for Neuroscience and American Society for Neural Therapy and Repair.
This faculty member has no reported relationships with industry.
Lad, EM; Karamchandani, JR; Alcorn, DM; Moshfeghi, DM; Egbert, PR. Retinal glioneuronal hamartoma in neurofibromatosis type 1. Archives of Ophthalmology. 2012;130:1335-1337. (2012) Abstract
Silva, RA; Murakami, Y; Lad, EM; Moshfeghi, DM. Stanford University network for diagnosis of retinopathy of prematurity (SUNDROP): 36-month experience with telemedicine screening. Ophthalmic Surgery, Lasers and Imaging. 2011;42:12-19. (2011) Abstract
Lad, EM; Jain, A; Lad, SP; Lin, RC; Alcorn, DM; Moshfeghi, DM. Orbital recurrence of B-progenitor acute lymphoblastic leukemia in a child. Journal of Pediatric Ophthalmology and Strabismus. 2010;47:46-50. (2010) Abstract
Lad, EM; Cheshier, SH; Kalani, MY. Wnt-signaling in retinal development and disease. Stem Cells and Development. 2009;18:7-16. (2009) Abstract
Lad, EM; Hernandez-Boussard, T; Morton, JM; Moshfeghi, DM. Incidence of retinopathy of prematurity in the United States: 1997 through 2005. American Journal of Ophthalmology. 2009;148:451-458. (2009) Abstract
Peyman, GA; Lad, EM; Moshfeghi, DM. Intravitreal injection of therapeutic agents. Retina: the Journal of Retinal and Vitreous Diseases. 2009;29:875-912. (2009) Abstract
Steece-Collier, K; Soderstrom, KE; Collier, TJ; Sortwell, CE; Maries-Lad, E. Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian rats. Journal of Comparative Neurology. 2009;515:15-30. (2009) Abstract
Lad, EM; Nguyen, TC; Morton, JM; Moshfeghi, DM. Retinopathy of prematurity in the United States. British Journal of Ophthalmology. 2008;92:320-325. (2008) Abstract
Lad, EM; Moshfeghi, DM. Minimizing the risk of endophthalmitis following intravitreal injections. Comprehensive Ophthalmology Update. 2006;7:277-284. (2006) Abstract
Maries, E; Kordower, JH; Chu, Y; Collier, TJ; Sortwell, CE; Olaru, E; Shannon, K; Steece-Collier, K. Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats. Neurobiology of Disease. 2006;21:165-180. (2006) Abstract
Maries, E; Dass, B; Collier, TJ; Kordower, JH; Steece-Collier, K. The role of alpha-synuclein in Parkinson's disease: insights from animal models. Nature Reviews Neuroscience. 2003;4:727-738. (2003) Abstract
Steece-Collier, K; Maries, E; Kordower, JH. Etiology of Parkinson's disease: Genetics and environment revisited. Proceedings of the National Academy of Sciences of USA. 2002;99:13972-13974. (2002) Abstract