Department / Division:
Radiology / Cardiac and Thoracic Imaging

Address:
DUMC 3808
Durham, NC 27710

Appointment Telephone:
919-684-2711

Office Telephone:
919-684-7311

Fax Telephone:
919-684-7168

• MD, University of Maryland School of Medicine, 1985

• Radiology, Brigham and Women's Hospital (Massachusetts), 1985-1990

• Thoracic Imaging, Brigham and Women's Hospital (Massachusetts), 1989-1990

Clinical Interests:
General thoracic imaging, PET imaging of the thorax, interventional procedures in the thorax, biomarkers

Research Interests:
There are numerous ongoing clinical and basic science investigations in the Thoracic Radiology Section.

Our laboratory work focuses on three fundamental translational areas;

1) Development of molecular imaging probes - We have used several different approaches, including phage display, and in collaboration with our colleagues in the Chemistry Department, a mass spectrometry based method.  These efforts are to develop novel imaging probes that characterize and phenotype tumors.

2) Discovery of novel lung cancer biomarkers – We have used a proteomics approach to discover serum protein biomarkers and developed a protein microarray for the detection of serum autoantibodies. These biomarkers are being evaluated as serum tests for the diagnosis of lung cancer.

3) Early cancer detection and understanding metastasis – In our effort to improve early detection strategies, we have several projects that study the process of metastasis. We are trying to understand the tumor-host interaction, and possible regulatory effects of the immune response in tumors.

Representative Publications:
Marom EM, Sarvis S, Herndon JE 2nd, Patz EF Jr. T1 lung cancers: sensitivity of diagnosis with fluorodeoxyglucose PET. Radiology. 2002 May;223(2):453-9. (2002) Abstract

Marom EM, Erasmus JJ, Pass HI, Patz EF Jr. The role of imaging in malignant pleural mesothelioma. Semin Oncol. 2002 Feb;29(1):26-35. (2002) Abstract

Heyneman LE, Patz EF. PET imaging in patients with bronchioloalveolar cell carcinoma. Lung Cancer. 2002 Dec;38(3):261-6. (2002) Abstract

Campa MJ, Serlin SB, Patz EF Jr. Development of novel tumor imaging agents with phage-display combinatorial peptide libraries. Acad Radiol. 2002 Aug;9(8):927-32. (2002) Abstract

Patz EF Jr, Goodman PC. Low-dose spiral computed tomography screening for lung cancer: not ready for prime time. Am J Respir Crit Care Med. 2001 Mar;163(4):813-4. (2001) Abstract

Patz EF Jr, Black WC, Goodman PC. CT screening for lung cancer: not ready for routine practice. Radiology. 2001 Dec;221(3):587-91; discussion 598-9. (2001) Abstract

Marom EM, Aloia TA, Moore MB, Hara M, Herndon JE 2nd, Harpole DH Jr, Goodman PC, Patz EF Jr. Correlation of FDG-PET imaging with Glut-1 and Glut-3 expression in early-stage non-small cell lung cancer. Lung Cancer. 2001 Aug-Sep;33(2-3):99-107. (2001) Abstract

Heyneman LE, Herndon JE, Goodman PC, Patz EF Jr. Stage distribution in patients with a small (less than or = 3 cm) primary nonsmall cell lung carcinoma. Implication for lung carcinoma screening. Cancer. 2001 Dec 15;92(12):3051-5. (2001) Abstract

Dammas S, Patz EF Jr, Goodman PC. Identification of small lung nodules at autopsy: implications for lung cancer screening and overdiagnosis bias. Lung Cancer. 2001 Jul;33(1):11-6. (2001) Abstract

Crotty E, Patz EF Jr. FDG-PET imaging in patients with paraneoplastic syndromes and suspected small cell lung cancer. J Thorac Imaging. 2001 Apr;16(2):89-93. (2001) Abstract

Aloia T, Bepler G, Harpole D, Goodman PC, McAdams HP, Erasmus JJ, Herndon JE, Patz EF Jr. Integration of peripheral blood biomarkers with computed tomography to differentiate benign from malignant pulmonary opacities. Cancer Detect Prev. 2001;25(4):336-43. (2001) Abstract

Patz EF Jr, McAdams HP, Erasmus JJ, Goodman PC, Culhane DK, Gilkeson RC, Herndon J. Sclerotherapy for malignant pleural effusions: a prospective randomized trial of bleomycin vs doxycycline with small-bore catheter drainage. Chest. 1998 May;113(5):1305-11. (1998) Abstract

Campa MJ, Schreiber G, Bepler G, Bishop MJ, McNutt RW, Chang KJ, Patz EF Jr. Characterization of delta opioid receptors in lung cancer using a novel nonpeptidic ligand. Cancer Res. 1996 Apr 1;56(7):1695-701. (1996) Abstract