Physicians

Clinical Director, Pediatric Cardiac Anesthesiology

Departments / Divisions

• Anesthesiology / Anesthesiology-Pediatric Division
• Pediatrics / Pediatrics-Chairman Office

Address
DUMC 3094
Durham, NC 27710

Office Telephone
919-681-4877

Fax Telephone
919-684-9894

Training

• MB ChB, University of Pretoria (South Africa), 1995

Residency

• Anesthesiology, Columbia University Medical Center (New York), 2004

Fellowship

• Pediatric Anesthesiology, Children's Hospital of New York, Columbia University, 2005

Clinical Interests
Pediatric anesthesiology, pediatric cardiac anesthesiology

Research Interests
Dr Jooste’s initial research focus was in the investigation of the smooth muscle airway effects of various non-depolarizing muscle relaxants. Recently, Dr Jooste has been involved in clinical research, investigating the pharmacokinetics and pharmacodynamics of anesthetic agents in children and in particular the cardiovascular effects of dexmedetomidine. His clinical practice focuses on the anesthesia care of children with congenital cardiac disease.

Industry Relationships and Collaborations (What's this?)

This faculty member has no reported relationships with industry.

Representative Publications
Chrysostomou, C; Sanchez-de-Toledo, J; Wearden, P; Jooste, EH; Lichtenstein, SE; Callahan, PM; Suresh, T; O'Malley, E; Shiderly, D; Haney, J; Yoshida, M; Orr, R; Munoz, R; Morell, VO. Perioperative use of dexmedetomidine is associated with decreased incidence of ventricular and supraventricular tachyarrhythmias after congenital cardiac operations. Annals of Thoracic Surgery. 2011;92:964-972. (2011) Abstract

Bailey, AG; McNaull, PP; Jooste, E; Tuchman, JB. Perioperative crystalloid and colloid fluid management in children: where are we and how did we get here?. Anesthesia and Analgesia. 2010;110:375-390. (2010) Abstract

Chrysostomou, C; Komarlu, R; Lichtenstein, S; Shiderly, D; Arora, G; Orr, R; Wearden, PD; Morell, VO; Munoz, R; Jooste, EH. Electrocardiographic effects of dexmedetomidine in patients with congenital heart disease. Intensive Care Medicine. 2010;36:836-842. (2010) Abstract

Jooste, EH; Muhly, WT; Ibinson, JW; Suresh, T; Damian, D; Phadke, A; Callahan, P; Miller, S; Feingold, B; Lichtenstein, SE; Cain, JG; Chrysostomou, C; Davis, PJ. Acute hemodynamic changes after rapid intravenous bolus dosing of dexmedetomidine in pediatric heart transplant patients undergoing routine cardiac catheterization. Anesthesia and Analgesia. 2010;111:1490-1496. (2010) Abstract

Lazol, JP; Lichtenstein, SE; Jooste, EH; Shiderly, D; Kudchadker, NA; Tatum, GH; Orr, RA; Wearden, PD; Morell, VO; Munoz, RA; Chrysostomou, C. Effect of dexmedetomidine on pulmonary artery pressure after congenital cardiac surgery: A pilot study. Pediatric Critical Care Medicine. 2010;11:589-592. (2010) Abstract

Manrique, AM; Arroyo, M; Lin, Y; El Khoudary, SR; Colvin, E; Lichtenstein, S; Chrysostomou, C; Orr, R; Jooste, E; Davis, P; Wearden, P; Morell, V; Munoz, R. Magnesium supplementation during cardiopulmonary bypass to prevent junctional ectopic tachycardia after pediatric cardiac surgery: a randomized controlled study. Journal of Thoracic and Cardiovascular Surgery. 2010;139:162-169.e2. (2010) Abstract

Tuchman, JB; Concetta Lupa, M; Jooste, EH. Emergency airway management of tracheo-innominate fistulas in the pediatric population. Canadian Journal of Anaesthesia. 2010;57:865-867. (2010) Abstract

Manrique, A; Jooste, EH; Kuch, BA; Lichtenstein, SE; Morell, V; Munoz, R; Ellis, D; Davis, PJ. The association of renal dysfunction and the use of aprotinin in patients undergoing congenital cardiac surgery requiring cardiopulmonary bypass. Anesthesia and Analgesia. 2009;109:45-52. (2009) Abstract

Jooste, E; Zhang, Y; Emala, CW. Neuromuscular blocking agents' differential bronchoconstrictive potential in Guinea pig airways. Anesthesiology. 2007;106:763-772. (2007) Abstract

Jooste, EH; Chalifoux, T; Broadman, LM. A perioperative strategy for the placement of a thoracic epidural catheter in a pediatric patient on high-dose enoxaprin. Paediatric Anaesthesia. 2007;17:907-909. (2007) Abstract

Jooste, E; Zhang, Y; Emala, CW. Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle. Anesthesiology. 2005;102:117-124. (2005) Abstract

Jooste, EH; Ohkawa, S; Sun, LS. Fiberoptic intubation with dexmedetomidine in two children with spinal cord impingements. Anesthesia and Analgesia. 2005;101:1248. (2005) Abstract

Jooste, EH; Sharma, A; Zhang, Y; Emala, CW. Rapacuronium augments acetylcholine-induced bronchoconstriction via positive allosteric interactions at the M3 muscarinic receptor. Anesthesiology. 2005;103:1195-1203. (2005) Abstract

Jooste, E; Klafter, F; Hirshman, CA; Emala, CW. A mechanism for rapacuronium-induced bronchospasm: M2 muscarinic receptor antagonism. Anesthesiology. 2003;98:906-911. (2003) Abstract