Physicians

Chief, Division of Surgical Oncology
Chief, Surgical Services, Durham VA Medical Center
Director, Melanoma Program, Duke Cancer Institute
Director, Surgical Oncology Clinical Operations, Duke University Health System
Vice Chairman, Department of Surgery

Department / Division
Surgery / Surgical Oncology

Address
DUMC 3118
Durham, NC 27710

Appointment Telephone
919-668-6688

Office Telephone
919-684-6858

Fax Telephone
919-684-6044

Training

• MD, Dartmouth Medical School (New Hampshire), 1985

Residency

• Surgery, Duke University Medical Center, 1985-1992

Fellowship

• Surgical Oncology, MD Anderson Cancer Center (Texas), 1992-1994

Clinical Interests
Surgical oncology; surgical treatment of pancreatic, gastric, colon, and rectal cancer; sphincter-preserving operations for rectal cancer; carcinoid tumors; melanoma, including intraoperative lymphatic mapping and sentinel lymph-node biopsy; hyperthermic isolated limb perfusion for melanoma and sarcoma, sarcomas or retroperitoneum, abdominal wall, and extremities

Research Interests
My research activities can be broken down into two categories: translational research and clinical trials research.
My translational research projects involve developing novel regional and sytemic treatment strategies for patients with malignant melanoma. We have developed animal models that mimic the human clinical situation of advanced extremity melanoma and systemic melanoma. Our approaches involve testing new/novel drugs that are themselves cytotoxic or inhibit various chemotherapy resistance pathways or signaling pathways that may decrease the effacacy of concurrently administered chemotehrapeutic agents. We collaborate closely with Dr Henry Friedman and Dr Francis Ali-Osman on these projects. In addition, we are also exploring how hyperthermia and vascular targeting agents can augment concurrently administered chemotherapy. The vascular targets we focus on are VEGF and N-cadherin. We colloborate closely with Dr Mark Dewhirst and Dr Ann Marie Pendergast on these studies. Finally, we are trying to develop genomic and immunologic predictors of response to treatment to help optimize as well as personalize treatment approaches in this melanoma patient population. These projects are in collaboration with Dr Joe Nevins and Dr Kent Weinhold.
My clinical research focuses on translating our benchtop research into novel phase I and II clinical trials for patients with advanced extremity melanoma. We have the largest regional therapy program for melanoma in the country and have several active multicenter trials which we initiated at Duke but also carry out at centers like MDACC, MSKCC, and Moffitt. These trials have both a clinical endpoint component as well as several correlative science projects built into them that try to validate our preclinical findings.
Our work, both preclinical and clinical, is currently funded through a VA Merit Review grant, industry support, and the Duke Melanoma Research Fund.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• ACTG
• Amgen, Inc.
• Bristol-Myers Squibb
• Novartis
• Schering-Plough Corp. (owned by Merck & Co, USA)

Representative Publications
Ceppa, EP; De la Fuente, SG; Reddy, SK; Stinnett, SS; Clary, BM; Tyler, DS; Pappas, TN; White, RR. Defining criteria for selective operative management of pancreatic cystic lesions: does size really matter?. Journal of Gastrointestinal Surgery. 2010;14:236-244. (2010) Abstract

Aldrink, JH; Selim, MA; Diesen, DL; Johnson, J; Pruitt, SK; Tyler, DS; Seigler, HF. Pediatric melanoma: a single-institution experience of 150 patients. Journal of Pediatric Surgery. 2009;44:1514-1521. (2009) Abstract

Augustine, CK; Yoo, JS; Potti, A; Yoshimoto, Y; Zipfel, PA; Friedman, HS; Nevins, JR; Ali-Osman, F; Tyler, DS. Genomic and molecular profiling predicts response to temozolomide in melanoma. Clinical Cancer Research. 2009;15:502-510. (2009) Abstract

Beasley, GM; Caudle, A; Petersen, RP; McMahon, NS; Padussis, J; Mosca, PJ; Zager, JS; Hochwald, SN; Grobmyer, SR; Delman, KA; Andtbacka, RH; Noyes, RD; Kane, JM; Seigler, H; Pruitt, SK; Ross, MI; Tyler, DS. A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US. Journal of the American College of Surgeons. 2009;208:706-715. (2009) Abstract

Beasley, GM; McMahon, N; Sanders, G; Augustine, CK; Selim, MA; Peterson, B; Norris, R; Peters, WP; Ross, MI; Tyler, DS. A phase 1 study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma. Cancer. 2009;115:4766-4774. (2009) Abstract

Beasley, GM; Tyler, DS. Optimizing regional therapy for melanoma. Annals of Surgical Oncology. 2009;16:1095-1097. (2009) Abstract

Choti, MA; Dixon, E; Tyler, D. Pretreatment assessment of resectable and borderline resectable pancreatic cancer: expert consensus statement by Callery et al. Annals of Surgical Oncology. 2009;16:1734-1735. (2009) Abstract

Coleman, A; Augustine, CK; Beasley, G; Sanders, G; Tyler, D. Optimizing regional infusion treatment strategies for melanoma of the extremities. Expert Review of Anticancer Therapy: an essential contribution to decision making in cancer care. 2009;9:1599-1609. (2009) Abstract

Erdmann, D; Pradka, SP; Similie, E; Marcus, JR; Moyer, KE; Shelburne, JD; Tyler, DS; Levin, SL. Plastic surgery within the Veterans Affairs Medical System: proposed modified indications for operative procedures. Annals of Plastic Surgery. 2009;63:105-110. (2009) Abstract

McMahon, N; Cheng, TY; Beasley, GM; Spasojevic, I; Petros, W; Augustine, CK; Zipfel, P; Padussis, JC; Sanders, G; Tyler, DS. Optimizing melphalan pharmacokinetics in regional melanoma therapy: does correcting for ideal body weight alter regional response or toxicity?. Annals of Surgical Oncology. 2009;16:953-961. (2009) Abstract

Nelson, JW; Ghafoori, AP; Willett, CG; Tyler, DS; Pappas, TN; Clary, BM; Hurwitz, HI; Bendell, JC; Morse, MA; Clough, RW; Czito, BG. Concurrent chemoradiotherapy in resected extrahepatic cholangiocarcinoma. International Journal of Radiation: Oncology - Biology - Physics. 2009;73:148-153. (2009) Abstract

Podoloff, DA; Ball, DW; Ben-Josef, E; Benson, AB; Cohen, SJ; Coleman, RE; Delbeke, D; Ho, M; Ilson, DH; Kalemkerian, GP; Lee, RJ; Loeffler, JS; Macapinlac, HA; Morgan, RJ; Siegel, BA; Singhal, S; Tyler, DS; Wong, RJ. NCCN task force: clinical utility of PET in a variety of tumor types. Journal of the National Comprehensive Cancer Network : JNCCN. 2009;7 Suppl 2:S1-26. (2009) Abstract

Santillan, AA; Delman, KA; Beasley, GM; Mosca, PJ; Hochwald, SN; Grobmyer, SR; Andtbacka, RH; Noyes, RD; Kane, JM; Ross, MI; Tyler, DS; Zager, JS. Predictive factors of regional toxicity and serum creatine phosphokinase levels after isolated limb infusion for melanoma: a multi-institutional analysis. Annals of Surgical Oncology. 2009;16:2570-2578. (2009) Abstract

Zink, SI; Soloff, EV; White, RR; Clary, BM; Tyler, DS; Pappas, TN; Paulson, EK. Pancreaticoduodenectomy: frequency and outcome of post-operative imaging-guided percutaneous drainage. Abdominal Imaging. 2009;34:767-771. (2009) Abstract

Augustine, CK; Yoshimoto, Y; Gupta, M; Zipfel, PA; Selim, MA; Febbo, P; Pendergast, AM; Peters, WP; Tyler, DS. Targeting N-cadherin enhances antitumor activity of cytotoxic therapies in melanoma treatment. Cancer Research. 2008;68:3777-3784. (2008) Abstract

Beasley, GM; Kahn, L; Tyler, DS. Current clinical and research approaches to optimizing regional chemotherapy: novel strategies generated through a better understanding of drug pharmacokinetics, drug resistance, and the development of clinically relevant animal models. Surgical Oncology Clinics of North America. 2008;17:731-viii. (2008) Abstract

Beasley, GM; Petersen, RP; Yoo, J; McMahon, N; Aloia, T; Petros, W; Sanders, G; Cheng, TY; Pruitt, SK; Seigler, H; Tyler, DS. Isolated limb infusion for in-transit malignant melanoma of the extremity: a well-tolerated but less effective alternative to hyperthermic isolated limb perfusion. Annals of Surgical Oncology. 2008;15:2195-2205. (2008) Abstract

Beasley, GM; Ross, MI; Tyler, DS. Future directions in regional treatment strategies for melanoma and sarcoma. International Journal of Hyperthermia. 2008;24:301-309. (2008) Abstract

Bhat, UG; Zipfel, PA; Tyler, DS; Gartel, AL. Novel anticancer compounds induce apoptosis in melanoma cells. Cell Cycle. 2008;7:1851-1855. (2008) Abstract

Padussis, JC; Steerman, SN; Tyler, DS; Mosca, PJ. Pharmacokinetics & drug resistance of melphalan in regional chemotherapy: ILP versus ILI. International Journal of Hyperthermia. 2008;24:239-249. (2008) Abstract

Scarborough, JE; Pietrobon, R; Bennett, KM; Clary, BM; Kuo, PC; Tyler, DS; Pappas, TN. Workforce projections for hepato-pancreato-biliary surgery. Journal of the American College of Surgeons. 2008;206:678-684. (2008) Abstract

Tyler, D. Regional therapeutic strategies in melanoma: not just local disease control, but an opportunity to develop novel therapeutic strategies with potential implications for systemic therapy. Annals of Surgical Oncology. 2008;15:2987-2990. (2008) Abstract

Tyler, D; Ross, M. The role that regional therapy plays in the current day management of cancer that is confined to the extremities. Introduction. International Journal of Hyperthermia. 2008;24:183. (2008) Abstract

Czito, BG; Bendell, JC; Willett, CG; Morse, MA; Blobe, GC; Tyler, DS; Thomas, J; Ludwig, KA; Mantyh, CR; Ashton, J; Yu, D; Hurwitz, HI. Bevacizumab, oxaliplatin, and capecitabine with radiation therapy in rectal cancer: Phase I trial results. International Journal of Radiation: Oncology - Biology - Physics. 2007;68:472-478. (2007) Abstract

Dannull, J; Lesher, DT; Holzknecht, R; Qi, W; Hanna, G; Seigler, H; Tyler, DS; Pruitt, SK. Immunoproteasome down-modulation enhances the ability of dendritic cells to stimulate antitumor immunity. Blood. 2007;110:4341-4350. (2007) Abstract

Demetri, GD; Baker, LH; Benjamin, RS; Casper, ES; Conrad, EU; D'Amato, GZ; DeLaney, TF; Ettinger, DS; Heck, R; Heslin, MJ; Hutchinson, RJ; Jacobs, CD; Kiel, K; Kraybill, WG; Letson, GD; O'Donnell, RJ; Paz, IB; Pfeifer, J; Pollock, RE; Randall, RL; Sasson, AR; Schupak, KD; Tyler, DS; von Mehren, M; Wayne, J; National Comprehensive Cancer Network. Soft tissue sarcoma. Journal of the National Comprehensive Cancer Network : JNCCN. 2007;5:364-399. (2007) Abstract

Demetri, GD; Benjamin, RS; Blanke, CD; Blay, JY; Casali, P; Choi, H; Corless, CL; Debiec-Rychter, M; DeMatteo, RP; Ettinger, DS; Fisher, GA; Fletcher, CD; Gronchi, A; Hohenberger, P; Hughes, M; Joensuu, H; Judson, I; Le Cesne, A; Maki, RG; Morse, M; Pappo, AS; Pisters, PW; Raut, CP; Reichardt, P; Tyler, DS; Van den Abbeele, AD; von Mehren, M; Wayne, JD; Zalcberg, J; NCCN Task Force. NCCN Task Force report: management of patients with gastrointestinal stromal tumor (GIST)--update of the NCCN clinical practice guidelines. Journal of the National Comprehensive Cancer Network : JNCCN. 2007;5 Suppl 2:S1-29. (2007) Abstract

Kelsey, CR; Nelson, JW; Willett, CG; Chino, JP; Clough, RW; Bendell, JC; Tyler, DS; Hurwitz, HI; Morse, MA; Clary, BM; Pappas, TN; Czito, BG. Duodenal adenocarcinoma: patterns of failure after resection and the role of chemoradiotherapy. International Journal of Radiation: Oncology - Biology - Physics. 2007;69:1436-1441. (2007) Abstract

Petersen, RP; Hanish, SI; Haney, JC; Miller, CC; Burfeind, WR; Tyler, DS; Seigler, HF; Wolfe, W; D'Amico, TA; Harpole, DH. Improved survival with pulmonary metastasectomy: an analysis of 1720 patients with pulmonary metastatic melanoma. Journal of Thoracic and Cardiovascular Surgery. 2007;133:104-110. (2007) Abstract

Reddy, SK; Tyler, DS; Pappas, TN; Clary, BM. Extended resection for pancreatic adenocarcinoma. The Oncologist. 2007;12:654-663. (2007) Abstract

Willett, CG; Czito, BG; Tyler, DS. Intraoperative radiation therapy. Journal of Clinical Oncology. 2007;25:971-977. (2007) Abstract

Yoshimoto, Y; Augustine, CK; Yoo, JS; Zipfel, PA; Selim, MA; Pruitt, SK; Friedman, HS; Ali-Osman, F; Tyler, DS. Defining regional infusion treatment strategies for extremity melanoma: comparative analysis of melphalan and temozolomide as regional chemotherapeutic agents. Molecular Cancer Therapeutics. 2007;6:1492-1500. (2007) Abstract

Cheng, TY; Sheth, K; White, RR; Ueno, T; Hung, CF; Clary, BM; Pappas, TN; Tyler, DS. Effect of neoadjuvant chemoradiation on operative mortality and morbidity for pancreaticoduodenectomy. Annals of Surgical Oncology. 2006;13:66-74. (2006) Abstract

Cornett, WR; McCall, LM; Petersen, RP; Ross, MI; Briele, HA; Noyes, RD; Sussman, JJ; Kraybill, WG; Kane, JM; Alexander, HR; Lee, JE; Mansfield, PF; Pingpank, JF; Winchester, DJ; White, RL; Chadaram, V; Herndon, JE; Fraker, DL; Tyler, DS; American College of Surgeons Oncology Group Trial Z0020. Randomized multicenter trial of hyperthermic isolated limb perfusion with melphalan alone compared with melphalan plus tumor necrosis factor: American College of Surgeons Oncology Group Trial Z0020. Journal of Clinical Oncology. 2006;24:4196-4201. (2006) Abstract

Czito, BG; Hong, TJ; Cohen, DP; Petros, WP; Tyler, DS; Pappas, TN; Yu, D; Lee, CG; Lockhart, AC; Morse, MA; Fernando, N; Hurwitz, HI. A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract. Cancer Investigation. 2006;24:9-17. (2006) Abstract

Czito, BG; Willett, CG; Bendell, JC; Morse, MA; Tyler, DS; Fernando, NH; Mantyh, CR; Blobe, GC; Honeycutt, W; Yu, D; Clary, BM; Pappas, TN; Ludwig, KA; Hurwitz, HI. Increased toxicity with gefitinib, capecitabine, and radiation therapy in pancreatic and rectal cancer: phase I trial results. Journal of Clinical Oncology. 2006;24:656-662. (2006) Abstract

Gaca, JG; Petersen, RP; Peterson, BL; Harpole, DH; D'Amico, TA; Pappas, TN; Seigler, HF; Wolfe, WG; Tyler, DS. Pathologic nodal status predicts disease-free survival after neoadjuvant chemoradiation for gastroesophageal junction carcinoma. Annals of Surgical Oncology. 2006;13:340-346. (2006) Abstract

Grubbs, EG; Abdel-Wahab, Z; Tyler, DS; Pruitt, SK. Utilizing quantitative polymerase chain reaction to evaluate prostate stem cell antigen as a tumor marker in pancreatic cancer. Annals of Surgical Oncology. 2006;13:1645-1654. (2006) Abstract

Horwhat, JD; Paulson, EK; McGrath, K; Branch, MS; Baillie, J; Tyler, D; Pappas, T; Enns, R; Robuck, G; Stiffler, H; Jowell, P. A randomized comparison of EUS-guided FNA versus CT or US-guided FNA for the evaluation of pancreatic mass lesions. Gastrointestinal Endoscopy. 2006;63:966-975. (2006) Abstract

Ko, SH; Ueno, T; Yoshimoto, Y; Yoo, JS; Abdel-Wahab, OI; Abdel-Wahab, Z; Chu, E; Pruitt, SK; Friedman, HS; Dewhirst, MW; Tyler, DS. Optimizing a novel regional chemotherapeutic agent against melanoma: hyperthermia-induced enhancement of temozolomide cytotoxicity. Clinical Cancer Research. 2006;12:289-297. (2006) Abstract

Onaitis, M; Ludwig, K; Perez-Tamayo, A; Gottfried, M; Russell, L; Shadduck, P; Pappas, T; Seigler, HF; Tyler, DS. The Kraske procedure: a critical analysis of a surgical approach for mid-rectal lesions. Journal of Surgical Oncology. 2006;94:194-202. (2006) Abstract

Posther, KE; Selim, MA; Mosca, PJ; Stanley, WE; Johnson, JL; Tyler, DS; Seigler, HF. Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma. Annals of Surgical Oncology. 2006;13:728-739. (2006) Abstract

Ravin, AG; Gottlieb, NB; Wang, HT; Meade, RA; Humphrey, JS; Schwarz, KW; Levin, LS; Tyler, DS; Erdmann, D. Effect of the Veterans Affairs Medical System on plastic surgery residency training. Plastic and Reconstructive Surgery. 2006;117:656-660. (2006) Abstract

Ueno, T; Ko, SH; Grubbs, E; Yoshimoto, Y; Augustine, C; Abdel-Wahab, Z; Cheng, TY; Abdel-Wahab, OI; Pruitt, SK; Friedman, HS; Tyler, DS. Modulation of chemotherapy resistance in regional therapy: a novel therapeutic approach to advanced extremity melanoma using intra-arterial temozolomide in combination with systemic O6-benzylguanine. Molecular Cancer Therapeutics. 2006;5:732-738. (2006) Abstract

White, RR; Kattan, MW; Haney, JC; Clary, BM; Pappas, TN; Tyler, DS; Brennan, MF. Evaluation of preoperative therapy for pancreatic cancer using a prognostic nomogram. Annals of Surgical Oncology. 2006;13:1485-1492. (2006) Abstract

Wong, SL; Morton, DL; Thompson, JF; Gershenwald, JE; Leong, SP; Reintgen, DS; Gutman, H; Sabel, MS; Carlson, GW; McMasters, KM; Tyler, DS; Goydos, JS; Eggermont, AM; Nieweg, OE; Cosimi, AB; Riker, AI; G Coit, D. Melanoma patients with positive sentinel nodes who did not undergo completion lymphadenectomy: a multi-institutional study. Annals of Surgical Oncology. 2006;13:809-816. (2006) Abstract

Abdel-Wahab, Z; Cisco, R; Dannull, J; Ueno, T; Abdel-Wahab, O; Kalady, MF; Onaitis, MW; Tyler, DS; Pruitt, SK. Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses. Journal of Surgical Research. 2005;124:264-273. (2005) Abstract

Aloia, TA; Grubbs, E; Onaitis, M; Mosca, PJ; Cheng, TY; Seigler, H; Tyler, DS. Predictors of outcome after hyperthermic isolated limb perfusion: role of tumor response. Archives of Surgery. 2005;140:1115-1120. (2005) Abstract

Czito, BG; Hurwitz, HI; Clough, RW; Tyler, DS; Morse, MA; Clary, BM; Pappas, TN; Fernando, NH; Willett, CG. Adjuvant external-beam radiotherapy with concurrent chemotherapy after resection of primary gallbladder carcinoma: a 23-year experience. International Journal of Radiation: Oncology - Biology - Physics. 2005;62:1030-1034. (2005) Abstract

Demetri, GD; Baker, LH; Beech, D; Benjamin, R; Casper, ES; Conrad, EU; DeLaney, TF; Ettinger, DS; Heslin, MJ; Hutchinson, RJ; Kiel, K; Kraybill, WG; Letson, GD; Neff, J; O'Donnell, RJ; Paz, IB; Pollock, RE; Randall, RL; Schupak, KD; Tyler, DS; von Mehren, M; Wayne, J; National Comprehensive Cancer Network. Soft tissue sarcoma clinical practice guidelines in oncology. Journal of the National Comprehensive Cancer Network : JNCCN. 2005;3:158-194. (2005) Abstract

Hall, JG; Herman, C; Cook, JL; Tyler, D; Seigler, HF; Mosca, PJ. Melanoma arising in a skin graft. Annals of Plastic Surgery. 2005;54:92-96. (2005) Abstract

McDermott, P; Lawson, DS; Walczak, R; Tyler, D; Shearer, IR. An isolated limb infusion technique: a guide for the perfusionist. Journal of Extra-Corporeal Technology. 2005;37:396-399. (2005) Abstract

Stewart, LE; Tyler, DS; Vollmer, RT. The importance of total number of sentinel lymph nodes in patients with stage N0 cutaneous melanoma. American Journal of Clinical Pathology. 2005;124:77-82. (2005) Abstract

Tempero, MA; Behrman, S; Ben-Josef, E; Benson, AB; Cameron, JL; Casper, ES; Hoffman, JP; Karl, RC; Kim, P; Koh, WJ; Kuvshinoff, BW; Melvin, WS; Muscarella, P; Sasson, AR; Shibata, S; Shrieve, DC; Talamonti, MS; Tyler, DS; Vickers, SM; Warren, RS; Willett, C; Wolff, RA; National Comprehensive Cancer Network. Pancreatic adenocarcinoma: Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network : JNCCN. 2005;3:598-626. (2005) Abstract

Tyler, DS; Balch, CM. Nomograms and staging in melanoma: new tools for better predicting outcomes. Annals of Surgical Oncology. 2005;12:267-269. (2005) Abstract

Volmar, KE; Cummings, TJ; Wang, WH; Creager, AJ; Tyler, DS; Xie, HB. Clear cell hidradenoma: a mimic of metastatic clear cell tumors. Archives of Pathology and Laboratory Medicine. 2005;129:e113-e116. (2005) Abstract

White, RR; Reddy, S; Tyler, DS. The role of chemoradiation therapy in locally advanced pancreatic cancer. Hepato Pancreato Biliary. 2005;7:109-113. (2005) Abstract

White, RR; Xie, HB; Gottfried, MR; Czito, BG; Hurwitz, HI; Morse, MA; Blobe, GC; Paulson, EK; Baillie, J; Branch, MS; Jowell, PS; Clary, BM; Pappas, TN; Tyler, DS. Significance of histological response to preoperative chemoradiotherapy for pancreatic cancer. Annals of Surgical Oncology. 2005;12:214-221. (2005) Abstract

Abdel-Wahab, OI; Grubbs, E; Viglianti, BL; Cheng, TY; Ueno, T; Ko, S; Rabbani, Z; Curtis, S; Pruitt, SK; Dewhirst, MW; Tyler, DS. The role of hyperthermia in regional alkylating agent chemotherapy. Clinical Cancer Research. 2004;10:5919-5929. (2004) Abstract

Cisco, RM; Abdel-Wahab, Z; Dannull, J; Nair, S; Tyler, DS; Gilboa, E; Vieweg, J; Daaka, Y; Pruitt, SK. Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4. Journal of Immunology. 2004;172:7162-7168. (2004) Abstract

Czito, BG; Hong, TJ; Cohen, DP; Tyler, DS; Lee, CG; Anscher, MS; Ludwig, KA; Seigler, HF; Mantyh, C; Morse, MA; Lockhart, AC; Petros, WP; Honeycutt, W; Spector, NL; Ertel, PJ; Mangum, SG; Hurwitz, HI. A Phase I trial of preoperative eniluracil plus 5-fluorouracil and radiation for locally advanced or unresectable adenocarcinoma of the rectum and colon. International Journal of Radiation: Oncology - Biology - Physics. 2004;58:779-785. (2004) Abstract

Gerke, H; Byrne, MF; Xie, HB; Paulson, EK; Tyler, DS; Baillie, J; Jowell, PS. A wolf in sheep's clothing: a non-functioning islet cell tumor of the pancreas masquerading as a microcystic (serous cystic) adenoma. Journal of the Pancreas. 2004;5:225-230. (2004) Abstract

Gerke, H; White, R; Byrne, MF; Stiffier, H; Mitchell, RM; Hurwitz, HI; Morse, MA; Branch, MS; Jowell, PS; Czito, B; Clary, B; Pappas, TN; Tyler, DS; Baillie, J. Complications of pancreaticoduodenectomy after neoadjuvant chemoradiation in patients with and without preoperative biliary drainage. Digestive and Liver Disease. 2004;36:412-418. (2004) Abstract

Grubbs, EG; Abdel-Wahab, O; Cheng, TY; Abdel-Wahab, Z; Peterson, B; Pruitt, SK; Colvin, OM; Friedman, HS; Tyler, DS. In-transit melanoma: the role of alkylating-agent resistance in regional therapy. Journal of the American College of Surgeons. 2004;199:419-427. (2004) Abstract

Grubbs, EG; Ueno, T; Abdel-Wahab, O; Cheng, TY; Pruitt, SK; Michael Colvin, O; Friedman, HS; Tyler, DS. Modulation of resistance to regional chemotherapy in the extremity melanoma model. Surgery. 2004;136:210-218. (2004) Abstract

Kalady, MF; Onaitis, MW; Emani, S; Abdel-Wahab, Z; Tyler, DS; Pruitt, SK. Sequential delivery of maturation stimuli increases human dendritic cell IL-12 production and enhances tumor antigen-specific immunogenicity. Journal of Surgical Research. 2004;116:24-31. (2004) Abstract

Kalady, MF; Onaitis, MW; Emani, S; Abdul-Wahab, Z; Pruitt, SK; Tyler, DS. Dendritic cells pulsed with pancreatic cancer total tumor RNA generate specific antipancreatic cancer T cells. Journal of Gastrointestinal Surgery. 2004;8:175-181. (2004) Abstract

Kalady, MF; Peterson, B; Baillie, J; Onaitis, MW; Abdul-Wahab, OI; Howden, JK; Jowell, PS; Branch, MS; Clary, BM; Pappas, TN; Tyler, DS. Pancreatic duct strictures: identifying risk of malignancy. Annals of Surgical Oncology. 2004;11:581-588. (2004) Abstract

Morse, MA; Lyerly, HK; Clay, TM; Abdel-Wahab, O; Chui, SY; Garst, J; Gollob, J; Grossi, PM; Kalady, M; Mosca, PJ; Onaitis, M; Sampson, JH; Seigler, HF; Toloza, EM; Tyler, D; Vieweg, J; Yang, Y. Immunotherapy of surgical malignancies. Current Problems in Surgery. 2004;41:15-132. (2004) Abstract

Mosca, PJ; Tyler, DS; Seigler, HF. Surgical management of cutaneous melanoma: current practice and impact on prognosis. Advances in Surgery. 2004;38:85-119. (2004) Abstract

Safford, SD; Coleman, RE; Gockerman, JP; Moore, J; Feldman, J; Onaitis, MW; Tyler, DS; Olson, JA. Iodine-131 metaiodobenzylguanidine treatment for metastatic carcinoid. Results in 98 patients. Cancer. 2004;101:1987-1993. (2004) Abstract

Tyler, D. Where are we going with regional therapy for melanoma?. Annals of Surgical Oncology. 2004;11:455-457. (2004) Abstract

Ueno, T; Ko, SH; Grubbs, E; Pruitt, SK; Friedman, HS; Tyler, DS. Temozolomide is a novel regional infusion agent for the treatment of advanced extremity melanoma. The American Journal of Surgery. 2004;188:532-537. (2004) Abstract

White, RR; Tyler, DS. Neoadjuvant therapy for pancreatic cancer: the Duke experience. Surgical Oncology Clinics of North America. 2004;13:675-x. (2004) Abstract

Abdel-Wahab, Z; Kalady, MF; Emani, S; Onaitis, MW; Abdel-Wahab, OI; Cisco, R; Wheless, L; Cheng, TY; Tyler, DS; Pruitt, SK. Induction of anti-melanoma CTL response using DC transfected with mutated mRNA encoding full-length Melan-A/MART-1 antigen with an A27L amino acid substitution. Cellular Immunology. 2003;224:86-97. (2003) Abstract

Cheng, TY; Grubbs, E; Abdul-Wahab, O; Leu, SY; Hung, CF; Petros, W; Aloia, T; Fedrau, R; Pruitt, S; Colvin, M; Friedman, H; Tyler, D. Marked variability of melphalan plasma drug levels during regional hyperthermic isolated limb perfusion. The American Journal of Surgery. 2003;186:460-467. (2003) Abstract

Kalady, MF; White, RR; Johnson, JL; Tyler, DS; Seigler, HF. Thin melanomas: predictive lethal characteristics from a 30-year clinical experience. Annals of Surgery. 2003;238:528-535. (2003) Abstract

Micames, C; Jowell, PS; White, R; Paulson, E; Nelson, R; Morse, M; Hurwitz, H; Pappas, T; Tyler, D; McGrath, K. Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-guided FNA vs. percutaneous FNA. Gastrointestinal Endoscopy. 2003;58:690-695. (2003) Abstract

Onaitis, M; Morse, M; Hurwitz, H; Cotton, P; Tyler, D; Clavien, P; Clary, B. Adjuvant hepatic arterial chemotherapy following metastasectomy in patients with isolated liver metastases. Annals of Surgery. 2003;237:782-788. (2003) Abstract

Onaitis, M; White, R; Tyler, D. Carcinoid tumors of the gastrointestinal tract. A review and the Duke University institutional overview. Minerva Chirurgica. 2003;58:1-8. (2003) Abstract

Onaitis, MW; Kalady, MF; Emani, S; Abdel-Wahab, Z; Tyler, DS; Pruitt, SK. CD40 ligand is essential for generation of specific cytotoxic T cell responses in RNA-pulsed dendritic cell immunotherapy. Surgery. 2003;134:300-305. (2003) Abstract

Safford, SD; Coleman, RE; Gockerman, JP; Moore, J; Feldman, JM; Leight, GS; Tyler, DS; Olson, JA. Iodine -131 metaiodobenzylguanidine is an effective treatment for malignant pheochromocytoma and paraganglioma. Surgery. 2003;134:956-962. (2003) Abstract

White, RR; Shah, AS; Tyler, DS. Pancreatic cancer since Halsted: how far have we come and where are we going?. Annals of Surgery. 2003;238:S132-S144. (2003) Abstract

Byrne, MF; Mitchell, RM; Stiffler, H; Jowell, PS; Branch, MS; Pappas, TN; Tyler, D; Baillie, J. Extensive investigation of patients with mild elevations of serum amylase and/or lipase is 'low yield'. Canadian Journal of Gastroenterology. 2002;16:849-854. (2002) Abstract

Kalady, MF; Clary, BM; Clark, LA; Gottfried, M; Rohren, EM; Coleman, RE; Pappas, TN; Tyler, DS. Clinical utility of positron emission tomography in the diagnosis and management of periampullary neoplasms. Annals of Surgical Oncology. 2002;9:799-806. (2002) Abstract

Kalady, MF; Clary, BM; Tyler, DS; Pappas, TN. Pancreas-preserving duodenectomy in the management of duodenal familial adenomatous polyposis. Journal of Gastrointestinal Surgery. 2002;6:82-87. (2002) Abstract

Kalady, MF; Onaitis, MW; Padilla, KM; Emani, S; Tyler, DS; Pruitt, SK. Enhanced dendritic cell antigen presentation in RNA-based immunotherapy. Journal of Surgical Research. 2002;105:17-24. (2002) Abstract

Kypson, AP; Onaitis, MW; Feldman, JM; Tyler, DS. Carcinoid and chylous ascites: an unusual association. Journal of Gastrointestinal Surgery. 2002;6:781-783. (2002) Abstract

Morse, MA; Nair, SK; Boczkowski, D; Tyler, D; Hurwitz, HI; Proia, A; Clay, TM; Schlom, J; Gilboa, E; Lyerly, HK. The feasibility and safety of immunotherapy with dendritic cells loaded with CEA mRNA following neoadjuvant chemoradiotherapy and resection of pancreatic cancer. International Journal of Gastrointestinal Cancer. 2002;32:1-6. (2002) Abstract

Onaitis, M; Kalady, MF; Pruitt, S; Tyler, DS. Dendritic cell gene therapy. Surgical Oncology Clinics of North America. 2002;11:645-660. (2002) Abstract

White, RR; Stanley, WE; Johnson, JL; Tyler, DS; Seigler, HF. Long-term survival in 2,505 patients with melanoma with regional lymph node metastasis. Annals of Surgery. 2002;235:879-887. (2002) Abstract

Kalady, MF; White, DC; Fields, RC; Coleman, RE; Schuler, FR; Seigler, HF; Tyler, DS. Validation of delayed sentinel lymph node mapping for melanoma. The Cancer Journal. 2001;7:503-508. (2001) Abstract

Onaitis, MW; Noone, RB; Fields, R; Hurwitz, H; Morse, M; Jowell, P; McGrath, K; Lee, C; Anscher, MS; Clary, B; Mantyh, C; Pappas, TN; Ludwig, K; Seigler, HF; Tyler, DS. Complete response to neoadjuvant chemoradiation for rectal cancer does not influence survival. Annals of Surgical Oncology. 2001;8:801-806. (2001) Abstract

Onaitis, MW; Noone, RB; Hartwig, M; Hurwitz, H; Morse, M; Jowell, P; McGrath, K; Lee, C; Anscher, MS; Clary, B; Mantyh, C; Pappas, TN; Ludwig, K; Seigler, HF; Tyler, DS. Neoadjuvant chemoradiation for rectal cancer: analysis of clinical outcomes from a 13-year institutional experience. Annals of Surgery. 2001;233:778-785. (2001) Abstract

Owen, SA; Sanders, LL; Edwards, LJ; Seigler, HF; Tyler, DS; Grichnik, JM. Identification of higher risk thin melanomas should be based on Breslow depth not Clark level IV. Cancer. 2001;91:983-991. (2001) Abstract

Tyler, D. Adenocarcinoma of the pancreas: is surgery making a difference?. American Journal of Gastroenterology. 2001;96:2532-2534. (2001) Abstract

White, RR; Hurwitz, HI; Morse, MA; Lee, C; Anscher, MS; Paulson, EK; Gottfried, MR; Baillie, J; Branch, MS; Jowell, PS; McGrath, KM; Clary, BM; Pappas, TN; Tyler, DS. Neoadjuvant chemoradiation for localized adenocarcinoma of the pancreas. Annals of Surgical Oncology. 2001;8:758-765. (2001) Abstract

White, RR; Paulson, EK; Freed, KS; Keogan, MT; Hurwitz, HI; Lee, C; Morse, MA; Gottfried, MR; Baillie, J; Branch, MS; Jowell, PS; McGrath, KM; Clary, BM; Pappas, TN; Tyler, DS. Staging of pancreatic cancer before and after neoadjuvant chemoradiation. Journal of Gastrointestinal Surgery. 2001;5:626-633. (2001) Abstract

Anscher, MS; Lee, C; Hurwitz, H; Tyler, D; Prosnitz, LR; Jowell, P; Rosner, G; Samulski, T; Dewhirst, MW. A pilot study of preoperative continuous infusion 5-fluorouracil, external microwave hyperthermia, and external beam radiotherapy for treatment of locally advanced, unresectable, or recurrent rectal cancer. International Journal of Radiation: Oncology - Biology - Physics. 2000;47:719-724. (2000) Abstract

Clary, BM; Tyler, DS; Dematos, P; Gottfried, M; Pappas, TN. Local ampullary resection with careful intraoperative frozen section evaluation for presumed benign ampullary neoplasms. Surgery. 2000;127:628-633. (2000) Abstract

Dong, XD; Tyler, D; Johnson, JL; DeMatos, P; Seigler, HF. Analysis of prognosis and disease progression after local recurrence of melanoma. Cancer. 2000;88:1063-1071. (2000) Abstract

Onaitis, MW; Kirshbom, PM; Hayward, TZ; Quayle, FJ; Feldman, JM; Seigler, HF; Tyler, DS. Gastrointestinal carcinoids: characterization by site of origin and hormone production. Annals of Surgery. 2000;232:549-556. (2000) Abstract

Tyler, DS; Onaitis, M; Kherani, A; Hata, A; Nicholson, E; Keogan, M; Fisher, S; Coleman, E; Seigler, HF. Positron emission tomography scanning in malignant melanoma. Cancer. 2000;89:1019-1025. (2000) Abstract

Tyler, DS; Shaha, AR; Udelsman, RA; Sherman, SI; Thompson, NW; Moley, JF; Evans, DB. Thyroid cancer: 1999 update. Annals of Surgical Oncology. 2000;7:376-398. (2000) Abstract

White, RR; Tyler, DS. Management of node-positive melanoma in the era of sentinel node biopsy. Surgical Oncology. 2000;9:119-125. (2000) Abstract

Clark, L; Ritter, E; Glazebrook, K; Tyler, D. Recurrent ductal carcinoma in situ after total mastectomy. Journal of Surgical Oncology. 1999;71:182-185. (1999) Abstract

Kirshbom, PM; Kherani, AR; Onaitis, MW; Hata, A; Kehoe, TE; Feldman, C; Feldman, JM; Tyler, DS. Foregut carcinoids: a clinical and biochemical analysis. Surgery. 1999;126:1105-1110. (1999) Abstract

St Louis, JD; Leight, GS; Tyler, DS. Follicular neoplasms: the role for observation, fine needle aspiration biopsy, thyroid suppression, and surgery. Journal of Surgical Oncology. 1999;16:5-11. (1999) Abstract

White, DC; Schuler, FR; Pruitt, SK; Culhane, DK; Seigler, HF; Coleman, RE; Tyler, D. Timing of sentinel lymph node mapping after lymphoscintigraphy. Surgery. 1999;126:156-161. (1999) Abstract

White, R; Lee, C; Anscher, M; Gottfried, M; Wolff, R; Keogan, M; Pappas, T; Hurwitz, H; Tyler, D. Preoperative chemoradiation for patients with locally advanced adenocarcinoma of the pancreas. Annals of Surgical Oncology. 1999;6:38-45. (1999) Abstract

DeMatos, P; Tyler, D; Seigler, HF. Mucosal melanoma of the female genitalia: a clinicopathologic study of forty-three cases at Duke University Medical Center. Surgery. 1998;124:38-48. (1998) Abstract

DeMatos, P; Tyler, DS; Seigler, HF. Malignant melanoma of the mucous membranes: a review of 119 cases. Annals of Surgical Oncology. 1998;5:733-742. (1998) Abstract

Keogan, MT; Tyler, D; Clark, L; Branch, MS; McDermott, VG; DeLong, DM; Coleman, RE. Diagnosis of pancreatic carcinoma: role of FDG PET. American Journal of Roentgenology. 1998;171:1565-1570. (1998) Abstract

Kirshbom, PM; Kherani, AR; Onaitis, MW; Feldman, JM; Tyler, DS. Carcinoids of unknown origin: comparative analysis with foregut, midgut, and hindgut carcinoids. Surgery. 1998;124:1063-1070. (1998) Abstract

Tyler, DS; Stanley, SD; Bartlett, JA; Bolognesi, DP; Weinhold, KJ. Lymphokine-activated killer (LAK) cell anti-HIV-1 ADCC reactivity: a potential strategy for reduction of virus-infected cellular reservoirs. Journal of Surgical Research. 1998;79:115-120. (1998) Abstract

Holzman, MD; Reintgen, KL; Tyler, DS; Pappas, TN. The role of laparoscopy in the management of suspected pancreatic and periampullary malignancies. Journal of Gastrointestinal Surgery. 1997;1:236-243. (1997) Abstract

Ritter, EF; Lee, CG; Tyler, D; Ferraro, F; Whiddon, C; Rudner, AM; Scully, S. Advances in prevention of radiation damage to visceral and solid organs in patients requiring radiation therapy of the trunk. Journal of Surgical Oncology. 1997;64:109-114. (1997) Abstract

Chari, RS; Tyler, DS; Anscher, MS; Russell, L; Clary, BM; Hathorn, J; Seigler, HF. Preoperative radiation and chemotherapy in the treatment of adenocarcinoma of the rectum. Annals of Surgery. 1995;221:778-786. (1995) Abstract

Tyler, DS; Francis, GM; Frederick, M; Tran, AH; Ordóñez, NG; Smith, JL; Eton, O; Ross, M; Grimm, EA. Interleukin-1 production in tumor cells of human melanoma surgical specimens. Journal of Interferon and Cytokine Research. 1995;15:331-340. (1995) Abstract

Tyler, DS; Evans, DB. Reoperative pancreaticoduodenectomy. Annals of Surgery. 1994;219:211-221. (1994) Abstract

Tyler, DS; Winchester, DJ; Caraway, NP; Hickey, RC; Evans, DB. Indeterminate fine-needle aspiration biopsy of the thyroid: identification of subgroups at high risk for invasive carcinoma. Surgery. 1994;116:1054-1060. (1994) Abstract

Tyler, D; Effmann, E; Shorter, N. Pyriform sinus cyst and fistula in the newborn: the value of endoscopic cannulation. Journal of Pediatric Surgery. 1992;27:1500-1501. (1992) Abstract

Stine, KC; Tyler, DS; Stanley, SD; Bartlett, JA; Bolognesi, DP; Weinhold, KJ. The effect of AZT on in vitro lymphokine-activated killer (LAK) activity in human immunodeficiency virus type-1 (HIV-1) infected individuals. Cellular Immunology. 1991;136:165-172. (1991) Abstract

Skinner, MA; Tyler, D; Branum, GD; Cucchiaro, G; Branum, MA; Meyers, WC. Subtotal colectomy for familial polyposis. A clinical series and review of the literature. Archives of Surgery. 1990;125:621-624. (1990) Abstract

Tyler, DS; Shaunak, S; Bartlett, JA; Iglehart, JD. HIV-1-associated thrombocytopenia. The role of splenectomy. Annals of Surgery. 1990;211:211-217. (1990) Abstract

Tyler, DS; Stanley, SD; Nastala, CA; Austin, AA; Bartlett, JA; Stine, KC; Lyerly, HK; Bolognesi, DP; Weinhold, KJ. Alterations in antibody-dependent cellular cytotoxicity during the course of HIV-1 infection. Humoral and cellular defects. Journal of Immunology. 1990;144:3375-3384. (1990) Abstract

Tyler, DS; Stanley, SD; Zolla-Pazner, S; Gorny, MK; Shadduck, PP; Langlois, AJ; Matthews, TJ; Bolognesi, DP; Palker, TJ; Weinhold, KJ. Identification of sites within gp41 that serve as targets for antibody-dependent cellular cytotoxicity by using human monoclonal antibodies. Journal of Immunology. 1990;145:3276-3282. (1990) Abstract

Weinhold, KJ; Tyler, DS; Lyerly, HK. Measurement of direct and indirect forms of anti-HIV-1 ADCC: implications for other retroviral disease. Developments in Biologicals. 1990;72:343-348. (1990) Abstract

Tyler, DS; Lyerly, HK; Nastala, CL; Shadduck, PP; Fitzpatrick, KT; Langlois, AJ; Moylan, JA. Barrier protection against the human immunodeficiency virus. Journal of Surgical Education. 1989;46:301-304. (1989) Abstract

Tyler, DS; Lyerly, HK; Weinhold, KJ. Anti-HIV-1 ADCC. AIDS Research and Human Retroviruses. 1989;5:557-563. (1989) Abstract

Tyler, DS; Nastala, CL; Stanley, SD; Matthews, TJ; Lyerly, HK; Bolognesi, DP; Weinhold, KJ. GP120 specific cellular cytotoxicity in HIV-1 seropositive individuals. Evidence for circulating CD16+ effector cells armed in vivo with cytophilic antibody. Journal of Immunology. 1989;142:1177-1182. (1989) Abstract

Weinhold, KJ; Lyerly, HK; Matthews, TJ; Tyler, DS; Ahearne, PM; Stine, KC; Langlois, AJ; Durack, DT; Bolognesi, DP. Cellular anti-GP120 cytolytic reactivities in HIV-1 seropositive individuals. Lancet. 1988;1:902-905. (1988) Abstract

Towpik, E; Kupiec-Weglinski, JW; Tyler, DS; Araujo, JL; Schneider, TM; Araneda, D; Murphy, GM; Tilney, NL. Cyclosporine and experimental skin allografts: long-term survival in rats treated with low maintenance doses. Plastic and Reconstructive Surgery. 1986;77:268-276. (1986) Abstract

Towpik, E; Kupiec-Weglinski, JW; Schneider, TM; Tyler, D; Padberg, W; Araneda, D; Tilney, NL. Cyclosporine and experimental skin allografts. II. Indefinite survival and development of specific immunologic unresponsiveness. Transplantation. 1985;40:714-718. (1985) Abstract