Physicians

Departments / Divisions

• Surgery / Neurosurgery
• Neurobiology

Address
DUMC 3807
Durham, NC 27710

Appointment Telephone
919-684-6706

Office Telephone
919-684-6706

Fax Telephone
919-681-8068

Training

• MD, Indiana University School of Medicine, 1975

Residency

• Neurosurgery, University of Washington Medical Center, 1976-1981

Fellowship

• Neurophysiology, Institute for Neurophysiology and University Hospital, University of Oslo (Norway), 1981-1982

Clinical Interests
Movement disorders, stereotactic neurosurgery, complex spine abnormalities, general adult neurosurgery

Research Interests
Current clinical research interests include clinical trials in Parkinson's disease, Alzheimer's disease, deep brain stimulation for depression, and sensory restoration for development of brain machine interfaces. Clinical treatments include deep brain stimulation, which is now a common procedure for treating Parkinson's disease and tremor. Basic science research interests focus on evaluation of metabolism changes with aging, particularly in response to ischemia and hypoglycemia, as well as epilepsy and seizure mechanisms as functions of both post-lesion injury and aging brain. These basic science interests include new approaches to optical imaging of the brain, cellular understanding of metabolism using direct substrate recordings (ie, oxygen, glucose, lactate) and developing new methods to understand complex interactions between neurons, astrocytes and blood vessels.

Industry Relationships and Collaborations (What's this?)

This faculty member (or a member of their immediate family) has a working relationship (i.e. consulting, research, and/or educational services) with the companies listed below. These relations have been reported to the health system leadership and, when appropriate, management plans are in place to address potential conflicts.

• Deep Brain Innovations
• Medtronics

Representative Publications
Galeffi, F; Somjen, GG; Foster, KA; Turner, DA. Simultaneous monitoring of tissue PO2 and NADH fluorescence during synaptic stimulation and spreading depression reveals a transient dissociation between oxygen utilization and mitochondrial redox state in rat hippocampal slices. Journal of Cerebral Blood Flow and Metabolism. 2011;31:626-639. (2011) Abstract

Gollub, RL; Turner, DA. Neuroinformatics in clinical and translational medicine--novel approaches. Neuroinformatics. 2010;8:207-212. (2010) Abstract

Marks, WJ; Bartus, RT; Siffert, J; Davis, CS; Lozano, A; Boulis, N; Vitek, J; Stacy, M; Turner, D; Verhagen, L; Bakay, R; Watts, R; Guthrie, B; Jankovic, J; Simpson, R; Tagliati, M; Alterman, R; Stern, M; Baltuch, G; Starr, PA; Larson, PS; Ostrem, JL; Nutt, J; Kieburtz, K; Kordower, JH; Olanow, CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurology. 2010;9:1164-1172. (2010) Abstract

Rizk, M; Bossetti, CA; Jochum, TA; Callender, SH; Nicolelis, MA; Turner, DA; Wolf, PD. A fully implantable 96-channel neural data acquisition system. Journal of Neural Engineering. 2009;6:026002. (2009) Abstract

Birdno, MJ; Kuncel, AM; Dorval, AD; Turner, DA; Grill, WM. Tremor varies as a function of the temporal regularity of deep brain stimulation. Neuroreport. 2008;19:599-602. (2008) Abstract

Foster, KA; Margraf, RR; Turner, DA. NADH hyperoxidation correlates with enhanced susceptibility of aged rats to hypoxia. Neurobiology of Aging. 2008;29:598-613. (2008) Abstract

Patil, PG; Turner, DA. The development of brain-machine interface neuroprosthetic devices. Neurotherapeutics. 2008;5:137-146. (2008) Abstract

Galeffi, F; Foster, KA; Sadgrove, MP; Beaver, CJ; Turner, DA. Lactate uptake contributes to the NAD(P)H biphasic response and tissue oxygen response during synaptic stimulation in area CA1 of rat hippocampal slices. Journal of Neurochemistry. 2007;103:2449-2461. (2007) Abstract

Sadgrove, MP; Beaver, CJ; Turner, DA. Effects of relative hypoglycemia on LTP and NADH imaging in rat hippocampal slices. Brain Research. 2007;1165:30-39. (2007) Abstract

Foster, KA; Galeffi, F; Gerich, FJ; Turner, DA; Muller, M. Optical and pharmacological tools to investigate the role of mitochondria during oxidative stress and neurodegeneration. Progress in Neurobiology. 2006;79:136-171. (2006) Abstract

Lang, AE; Gill, S; Patel, NK; Lozano, A; Nutt, JG; Penn, R; Brooks, DJ; Hotton, G; Moro, E; Heywood, P; Brodsky, MA; Burchiel, K; Kelly, P; Dalvi, A; Scott, B; Stacy, M; Turner, D; Wooten, VG; Elias, WJ; Laws, ER; Dhawan, V; Stoessl, AJ; Matcham, J; Coffey, RJ; Traub, M. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Annals of Neurology. 2006;59:459-466. (2006) Abstract

Foster, KA; Beaver, CJ; Turner, DA. Interaction between tissue oxygen tension and NADH imaging during synaptic stimulation and hypoxia in rat hippocampal slices. Neuroscience. 2005;132:645-657. (2005) Abstract

Patil, PG; Turner, DA; Pietrobon, R. National trends in surgical procedures for degenerative cervical spine disease: 1990-2000. Neurosurgery. 2005;57:753-758. (2005) Abstract

Patil, PG; Carmena, JM; Nicolelis, MA; Turner, DA. Ensemble recordings of human subcortical neurons as a source of motor control signals for a brain-machine interface. Neurosurgery. 2004;55:27-35. (2004) Abstract

Smith-Hammond, CA; New, KC; Pietrobon, R; Curtis, DJ; Scharver, CH; Turner, DA. Prospective analysis of incidence and risk factors of dysphagia in spine surgery patients: comparison of anterior cervical, posterior cervical, and lumbar procedures. Spine. 2004;29:1441-1446. (2004) Abstract

Turner, DA; Shetty, AK. Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy. Neurosurgery. 2003;52:632-644. (2003) Abstract

Fayuk, D; Aitken, PG; Somjen, GG; Turner, DA. Two different mechanisms underlie reversible, intrinsic optical signals in rat hippocampal slices. Journal of Neurophysiology. 2002;87:1924-1937. (2002) Abstract

Speciale, AC; Pietrobon, R; Urban, CW; Richardson, WJ; Helms, CA; Major, N; Enterline, D; Hey, L; Haglund, M; Turner, DA. Observer variability in assessing lumbar spinal stenosis severity on magnetic resonance imaging and its relation to cross-sectional spinal canal area. Spine. 2002;27:1082-1086. (2002) Abstract

Danisa, OA; Turner, D; Richardson, WJ. Surgical correction of lumbar kyphotic deformity: posterior reduction "eggshell" osteotomy. Journal of Neurosurgery. 2000;92:50-56. (2000) Abstract